Juliette Léon
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View article: Long-term Graft and Patient Survival in Kidney Transplant Recipients With High Levels of Preformed DSAs (MFI > 3000): A Propensity Score–matched Analysis
Long-term Graft and Patient Survival in Kidney Transplant Recipients With High Levels of Preformed DSAs (MFI > 3000): A Propensity Score–matched Analysis Open
Background. Kidney transplant recipients with preformed donor-specific antibodies (DSAs) are at higher risk for antibody-mediated rejection (AMR) and graft failure. This study assesses outcomes during a 15-y period, comparing patients with…
View article: In situ Complementomics enables spatial complement activation profiling and identification of therapeutic targets across human tissues
In situ Complementomics enables spatial complement activation profiling and identification of therapeutic targets across human tissues Open
Complement activation is increasingly recognized as a driver of inflammation in diverse human diseases, prompting the development of targeted inhibitors across the cascade. However, despite compelling preclinical evidence, clinical success…
View article: Tolerance Induction Strategies in Organ Transplantation: Current Status and Future Perspectives
Tolerance Induction Strategies in Organ Transplantation: Current Status and Future Perspectives Open
Achieving donor-specific immune tolerance has the potential to eliminate the need for lifelong immunosuppression in transplant recipients, but translating this goal into clinical practice remains challenging. Unlike laboratory rodents, hum…
View article: Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future
Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future Open
Calcineurin inhibitors (CNIs) are a cornerstone of post-transplant immunosuppressive regimens. However, their use is associated with adverse effects, most notably chronic nephrotoxicity, which remains a leading cause of long-term allograft…
View article: Histologic and molecular features shared between antibody‐mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis
Histologic and molecular features shared between antibody‐mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis Open
Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a ‘maternal‐f…
View article: Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen
Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen Open
View article: An integrated transcription factor framework for Treg identity and diversity
An integrated transcription factor framework for Treg identity and diversity Open
Vertebrate cell identity depends on the combined activity of scores of transcription factors (TF). While TFs have often been studied in isolation, a systematic perspective on their integration has been missing. Focusing on FoxP3+ regulator…
View article: Deciphering the mechanisms by which FoxP3 regulates treg identity : an analysis of naturally occurring IPEX mutations
Deciphering the mechanisms by which FoxP3 regulates treg identity : an analysis of naturally occurring IPEX mutations Open
The transcription factor (TF) FoxP3 plays a crucial role in the immune system by directing the development and function of regulatory T cells (Tregs). These cells maintain immune homeostasis and prevent autoimmunity by suppressing aberrant…
View article: Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction
Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction Open
View article: An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity
An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity Open
FoxP3+CD4+ regulatory T cells (Tregs), essential for immunologic and organismal homeostasis, have diverse functions and corresponding gene expression programs. How the many controlling transcription factors (TFs) organize to determine Treg…
View article: Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers
Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers Open
Technologies that facilitate the bulk sequencing of small numbers of cells as well as single-cell RNA sequencing (scRNA-seq) have aided greatly in the study of viruses as these analyses can be used to differentiate responses from infected …
View article: De novo posttransplant membranous nephropathy following BNT162b2 mRNA COVID-19 vaccine in a kidney transplant recipient
De novo posttransplant membranous nephropathy following BNT162b2 mRNA COVID-19 vaccine in a kidney transplant recipient Open
View article: The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis Open
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here demonstrated that unlike other …
View article: FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis
FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis Open
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here demonstrate that, unlike other …
View article: FoxP3 associates with enhancer-promoter loops to regulate T<sub>reg</sub>-specific gene expression.
FoxP3 associates with enhancer-promoter loops to regulate T<sub>reg</sub>-specific gene expression. Open
Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell (Treg) identity is dominantly specified by the transcription factor (TF) FoxP3, whose mechanism of …
View article: A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface Open
Significance By modeling in vitro the cross-talk between epithelial and immune cells, this work provides possible origins for the profound inflammatory perturbations that are a hallmark of COVID-19, and the relative protection of children …
View article: Table of Contents
Table of Contents Open
View article: FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression
FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression Open
SUMMARY Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPL). T regulatory cells (Treg) identity is dominantly specified by the transcription factor FoxP3, whose mechanism of action i…
View article: Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction Open
View article: Corrigendum: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study
Corrigendum: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study Open
[This corrects the article DOI: 10.3389/fimmu.2021.624821.].
View article: A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface Open
Infection by SARS-CoV2 provokes a potentially fatal pneumonia with multiorgan failure, and high systemic inflammation. To gain mechanistic insight and ferret out the root of this immune dysregulation, we modeled by in vitro co-culture the …
View article: Profound Treg perturbations correlate with COVID-19 severity
Profound Treg perturbations correlate with COVID-19 severity Open
Significance Regulatory T cells (Tregs) are responsible for restraining excessive inflammation, a hallmark of COVID-19. We identified a striking phenotype in Tregs from patients with severe disease, as well as an interesting role for inter…
View article: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study
Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study Open
Kidney disease affects 10% of the world population and is associated with increased mortality. Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage kidney disease in children, often failing standard immunosuppression…
View article: Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations Open
View article: A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control <i>scurfy</i> syndrome
A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control <i>scurfy</i> syndrome Open
Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by mutations in forkhead box P3 (FOXP3), which lead to the loss of function of regulatory T cells (Tregs) and the development of autoimmune manifestat…
View article: Profound Treg perturbations correlate with COVID-19 severity
Profound Treg perturbations correlate with COVID-19 severity Open
Summary The hallmark of severe COVID-19 disease has been an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We explored the hypothesis that perturbations in FoxP3+ T regulatory cells (Treg), …
View article: Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis
Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis Open
View article: Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis
Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis Open
Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master compleme…
View article: Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation
Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation Open
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocyte…
View article: Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4<sup>+</sup>T cell perturbations
Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4<sup>+</sup>T cell perturbations Open
FOXP3 deficiency in humans with IPEX syndrome and mice results in fatal systemic autoimmunity by altering regulatory T cell (Treg) physiology, but actual cellular and molecular mechanisms of disease are unclear, part because Treg surface m…