Julio C. Facelli
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View article: Air pollution mixtures and stillbirth: k-means cluster analysis
Air pollution mixtures and stillbirth: k-means cluster analysis Open
Background: Preventing stillbirths starts with identifying modifiable risk factors, such as air pollution (AP). Most research has focused on individual components of AP (e.g. PM2.5) to assess the linear relationship between air pollutant c…
View article: Structural Homology and Electrostatic Potential Comparisons of Epitope Pair Candidates for Molecular Mimicry Triggering of Type 1 Diabetes Mellitus
Structural Homology and Electrostatic Potential Comparisons of Epitope Pair Candidates for Molecular Mimicry Triggering of Type 1 Diabetes Mellitus Open
Background Molecular mimicry, where foreign and self-peptides contain similar epitopes, can induce autoimmune responses. Identifying potential molecular mimics and studying their properties is key to understanding the onset of autoimmune d…
View article: Scaling Sensor Metadata Extraction for Exposure Health Using LLMs
Scaling Sensor Metadata Extraction for Exposure Health Using LLMs Open
Background The rapid evolution and diversity of sensor technologies, coupled with inconsistencies in how sensor metadata is reported across formats and sources, present significant challenges for generating exposomes and exposure health re…
View article: Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos
Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos Open
Objectives Type 2 diabetes (T2D) is a growing public health burden with persistent racial and ethnic disparities. . This study assessed the completeness of social determinants of health (SdoH) data for patients with T2D in Epic Cosmos, a n…
View article: Conceptual framework for prediction models of patient deterioration based on nursing documentation patterns: reproducibility and generalizability with a large number of hospitals across the United States
Conceptual framework for prediction models of patient deterioration based on nursing documentation patterns: reproducibility and generalizability with a large number of hospitals across the United States Open
View article: Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning
Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning Open
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder marked by cerebellar dysfunction, ataxic gait, and progressive motor impairments. SCA2 is caused by the pathologic expansion of CAG repeats in the ata…
View article: Conformal Learning for Quantifying Uncertainty in Psychiatric Condition Predictions
Conformal Learning for Quantifying Uncertainty in Psychiatric Condition Predictions Open
Purpose The combination of physiological data from ubiquitous fitness trackers like Fitbit® and machine learning presents a promising avenue for improving diagnostic consistency in the psychiatric space. However, machine learning models th…
View article: 20 Decoding auto-immunity: Uncovering pre-onset infectious disease patterns of idiopathic inflammatory myopathies
20 Decoding auto-immunity: Uncovering pre-onset infectious disease patterns of idiopathic inflammatory myopathies Open
Objectives/Goals: Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases influenced by genetic and environmental factors. This study aims to explore infection patterns preceding IIM onset by applying temporal data mining and mac…
View article: 384 A systematic approach to understanding nursing documentation tasks
384 A systematic approach to understanding nursing documentation tasks Open
Objectives/Goals: Healthcare organizations must track electronic health record (EHR) activity at the user level, including logons, accessed records, and viewed or entered documentation. There is little standardization in EHR audit logs and…
View article: 357 On the completeness of medical records of patients with oral health records at three CTSA CORES Institutions: Iowa, Kentucky, and Utah
357 On the completeness of medical records of patients with oral health records at three CTSA CORES Institutions: Iowa, Kentucky, and Utah Open
Objectives/Goals: Oral health is an important and understudied part of overall health. Poor oral health is linked to many systemic conditions, but little has been done to explore these issues in large electronic health records data sources…
View article: 363 The art and science of data navigation for translational research
363 The art and science of data navigation for translational research Open
Objectives/Goals: Translational researchers spend significant amounts of time finding available datasets and other research data resources for their purposes. Objectives of this program are develop and evaluate a multipronged approach to s…
View article: 347 Modeling long-term environmental effects on discrete events using shapelets: An application for stillbirth
347 Modeling long-term environmental effects on discrete events using shapelets: An application for stillbirth Open
Objectives/Goals: To develop an informatics framework that will allow study of environmental effects on stillbirth at large scale (i.e., US-level) and leverage recent advances in machine learning and artificial intelligence to produce repr…
View article: Molecular mimicry impact of the COVID-19 pandemic: Sequence homology between SARS-CoV-2 and autoimmune diseases epitopes
Molecular mimicry impact of the COVID-19 pandemic: Sequence homology between SARS-CoV-2 and autoimmune diseases epitopes Open
Molecular mimicry is one mechanism by which an infectious agent may trigger an autoimmune disease in a human subject and occurs when foreign- and self-peptides contain similar epitopes that activate an autoimmune response in a susceptible …
View article: Conceptual Framework for Prediction Models of Patient Deterioration Based on Nursing Documentation Patterns: Reproducibility and Generalizability with a Large Number of Hospitals Across the United States
Conceptual Framework for Prediction Models of Patient Deterioration Based on Nursing Documentation Patterns: Reproducibility and Generalizability with a Large Number of Hospitals Across the United States Open
View article: Data science and artificial intelligence in biology, health, and healthcare
Data science and artificial intelligence in biology, health, and healthcare Open
View article: Constructing Probabilistic Human Mobility Patterns for Estimating Total Exposures and Pathogen Transmission Using Aggregate Mobile Phone Data
Constructing Probabilistic Human Mobility Patterns for Estimating Total Exposures and Pathogen Transmission Using Aggregate Mobile Phone Data Open
While phone location data is widely collected by providers and shared under special agreements with data aggregators, it is not available for research or routine surveillance purposes. Moreover, raw phone data may expose personal travel pa…
View article: Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis
Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis Open
Background Type 2 diabetes (T2D) represents a major public health burden in the United States, with racial disparities in medication use potentially exacerbating inequities in health outcomes. This study examined racial/ethnic differences …
View article: Predicting the onset of Alzheimer’s disease and related dementia using electronic health records: findings from the cache county study on memory in aging (1995–2008)
Predicting the onset of Alzheimer’s disease and related dementia using electronic health records: findings from the cache county study on memory in aging (1995–2008) Open
View article: Characterization and Racial Stratification of Social Determinants of Health for Individuals with Type 2 Diabetes as Recorded in Electronic Health Records: Implications for Artificial Intelligence Development
Characterization and Racial Stratification of Social Determinants of Health for Individuals with Type 2 Diabetes as Recorded in Electronic Health Records: Implications for Artificial Intelligence Development Open
Background Accurate documentation of social determinants of health (SDoH) in electronic health records (EHRs) is critical for developing equitable AI models for diabetes management. This study investigates SDoH data in a cross-institutiona…
View article: Predicting the onset of Alzheimer’s disease and related dementia using Electronic Health Records: Findings from the Cache County Study on Memory in Aging (1995–2008)
Predicting the onset of Alzheimer’s disease and related dementia using Electronic Health Records: Findings from the Cache County Study on Memory in Aging (1995–2008) Open
Introduction: Clinical notes, biomarkers, and neuroimaging have been proven valuable in dementia prediction models. Whether commonly available structured clinical data can predict dementia is an emerging area of research. We aimed to predi…
View article: A Scalable and Extensible Logical Data Model of Electronic Health Record Audit Logs for Temporal Data Mining (RNteract): Model Conceptualization and Formulation
A Scalable and Extensible Logical Data Model of Electronic Health Record Audit Logs for Temporal Data Mining (RNteract): Model Conceptualization and Formulation Open
Background Increased workload, including workload related to electronic health record (EHR) documentation, is reported as a main contributor to nurse burnout and adversely affects patient safety and nurse satisfaction. Traditional methods …
View article: 130 Developing a Conceptual Data Model for Nursing Workload
130 Developing a Conceptual Data Model for Nursing Workload Open
OBJECTIVES/GOALS: Nurses are leaving the profession at an alarming rate due to increased workload and burnout.#_msocom_1 Computational models that are reliable and reproducible are needed to quantitatively examine nursing workload and esti…
View article: Uncertainty in Breast Cancer Risk Prediction: A Conformal Prediction Study of Race Stratification
Uncertainty in Breast Cancer Risk Prediction: A Conformal Prediction Study of Race Stratification Open
The use of Artificial Intelligence (AI) in medicine has attracted a great deal of attention in the medical literature, but less is known about how to assess the uncertainty of individual predictions in clinical applications. This paper dem…
View article: An Open Science Grid Implementation of the Steady State Genetic Algorithm for Crystal Structure Prediction
An Open Science Grid Implementation of the Steady State Genetic Algorithm for Crystal Structure Prediction Open
View article: Patient Deterioration Prediction Models Using Nursing Documentation Patterns as Predictors: A Reproducibility and Generalizability Study Across a Large Number of Hospitals Across the United States
Patient Deterioration Prediction Models Using Nursing Documentation Patterns as Predictors: A Reproducibility and Generalizability Study Across a Large Number of Hospitals Across the United States Open
View article: An Open Science Grid Implementation of the Steady State Genetic Algorithm for Crystal Structure Prediction
An Open Science Grid Implementation of the Steady State Genetic Algorithm for Crystal Structure Prediction Open
View article: A Rare Variant in MDH2 (rs111879470) Is Associated with Predisposition to Recurrent Breast Cancer in an Extended High-Risk Pedigree
A Rare Variant in MDH2 (rs111879470) Is Associated with Predisposition to Recurrent Breast Cancer in an Extended High-Risk Pedigree Open
A significant fraction of breast cancer recurs, with lethal outcome, but specific genetic variants responsible have yet to be identified. Five cousin pairs with recurrent breast cancer from pedigrees with a statistical excess of recurrent …
View article: Molecular dynamics study of the mechanical properties of drug loaded model systems: A comparison of a polymersome with a bilayer
Molecular dynamics study of the mechanical properties of drug loaded model systems: A comparison of a polymersome with a bilayer Open
In this work we implement a new methodology to study structural and mechanical properties of systems having spherical and planar symmetries throughout Molecular Dynamics simulations. This methodology is applied here to a drug delivery syst…
View article: Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology Open
View article: Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, pr…