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View article: Perceptions of persons deprived of liberty regarding tuberculosis vaccine research
Perceptions of persons deprived of liberty regarding tuberculosis vaccine research Open
Several tuberculosis (TB) vaccine candidates are currently advancing to late-stage clinical trials. Prisons in low-and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of liberty (PDL) an…
View article: Proposal of a Vaccination Needs Index to Prioritise Municipal Interventions in Brazil
Proposal of a Vaccination Needs Index to Prioritise Municipal Interventions in Brazil Open
Addressing population health needs requires integrating indicators expressed on non‐comparable scales, particularly for vaccination, a cornerstone of public health. Objective To propose and implement a Vaccination Needs Index based on nati…
View article: Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study
Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study Open
Background The World Health Organization recommends systematic active case finding for tuberculosis (TB) among high-risk populations, including incarcerated individuals; however, many prisons lack screening capacity. In this study, we aime…
View article: Adverse Events and Immunization Errors Following a Mass Immunization Campaignwith TAK‐003 in Dourados, Brazil: <i>A Post‐Marketing Safety Surveillance Analysis</i>
Adverse Events and Immunization Errors Following a Mass Immunization Campaignwith TAK‐003 in Dourados, Brazil: <i>A Post‐Marketing Safety Surveillance Analysis</i> Open
This descriptive observational study based on post‐marketing surveillance data evaluates adverse events following immunization (AEFI) associated with the TAK‐003 (Qdenga®) vaccine. Conducted in Dourados, Brazil, between January and Novembe…
View article: Longitudinal symptom transitions predict incident tuberculosis risk among persons deprived of liberty in Brazil
Longitudinal symptom transitions predict incident tuberculosis risk among persons deprived of liberty in Brazil Open
Tuberculosis (TB) screening often relies on cross-sectional symptom assessment. To determine the added value of longitudinal symptom monitoring, we conducted a prospective cohort study among 2,282 incarcerated men in Brazil without TB. Eve…
View article: Tuberculosis treatment outcomes after transfer or release from incarceration: a retrospective cohort study from Brazil
Tuberculosis treatment outcomes after transfer or release from incarceration: a retrospective cohort study from Brazil Open
Background Tuberculosis (TB) disproportionately affects people deprived of liberty (PDL). Prior studies have shown higher TB treatment completion rates among PDL compared to the general population. However, little is known about how incarc…
View article: The effectiveness, cost-effectiveness, budget impact, and return on investment of scaling up tuberculosis screening and preventive treatment in Brazil, Georgia, Kenya, and South Africa: a modelling study
The effectiveness, cost-effectiveness, budget impact, and return on investment of scaling up tuberculosis screening and preventive treatment in Brazil, Georgia, Kenya, and South Africa: a modelling study Open
World Health Organization.
View article: The evolution of dengue fever trends in the Central-West Region of Brazil: An 11-year analysis of incidence data from 2013 to 2023 in Mato Grosso do Sul
The evolution of dengue fever trends in the Central-West Region of Brazil: An 11-year analysis of incidence data from 2013 to 2023 in Mato Grosso do Sul Open
Dengue is a public health challenge in Mato Grosso do Sul. Preventive interventions are crucial to alleviate disease burden and control outbreaks.
View article: Comparative impacts and cost-effectiveness of tuberculosis active case-finding strategies in prisons in Brazil, Colombia, and Peru: a mathematical modeling study
Comparative impacts and cost-effectiveness of tuberculosis active case-finding strategies in prisons in Brazil, Colombia, and Peru: a mathematical modeling study Open
Background Incarceration is a leading driver of tuberculosis in Latin America. Active case-finding in prisons may reduce population-wide tuberculosis burden, but optimal strategies and cost-effectiveness remain uncertain. Methods and findi…
View article: Comparison of phylogenetic metrics of transmission in symptomatic and asymptomatic tuberculosis
Comparison of phylogenetic metrics of transmission in symptomatic and asymptomatic tuberculosis Open
Summary Background Understanding drivers of Mycobacterium tuberculosis ( Mtb ) transmission remains a critical challenge in high-burden settings. Tuberculosis control efforts traditionally target symptomatic individuals, yet the role of as…
View article: Perceptions of persons deprived of liberty regarding tuberculosis vaccine research
Perceptions of persons deprived of liberty regarding tuberculosis vaccine research Open
Background Several tuberculosis (TB) vaccine candidates are currently advancing to late stage clinical trials. Prisons in low- and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of libe…
View article: Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil
Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil Open
Objectives To compare antispike IgG levels over a period of 182 days of follow-up in healthy adults who received full or fractional booster doses of BNT162b2 or AZD1222 after completing a primary series of Sinovac, BNT162b2 or AZD1222. Des…
View article: Coverage and inequalities in COVID-19 and influenza vaccination in Brazil: a nationwide cross-sectional survey
Coverage and inequalities in COVID-19 and influenza vaccination in Brazil: a nationwide cross-sectional survey Open
This nationwide cross-sectional survey in Brazil investigated COVID-19 and influenza vaccination coverage and inequalities. Data from 33 250 interviews conducted between March and June 2024 in 133 sentinel cities revealed high overall cove…
View article: The role of tuberculosis symptoms in transmission risk to cell contacts in prisons
The role of tuberculosis symptoms in transmission risk to cell contacts in prisons Open
Background Understanding determinants of Mycobacterium tuberculosis transmission is critical to devising effective strategies to reduce its burden. Whether and to what extent symptoms influence transmission remains poorly understood. Metho…
View article: Tuberculosis treatment outcomes after transfer or release from incarceration: A retrospective cohort study from Brazil
Tuberculosis treatment outcomes after transfer or release from incarceration: A retrospective cohort study from Brazil Open
Background Tuberculosis (TB) disproportionately affects people deprived of liberty. Prior studies have shown higher TB treatment completion rates among incarcerated individuals compared to the general population. However, little is known a…
View article: Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study
Evaluation of an ultra-portable X-ray system with automated interpretation for tuberculosis active case finding in carceral settings: a diagnostic test accuracy study Open
Background The World Health Organization recommends systematic active case finding for tuberculosis (TB) among high-risk population including incarcerated individuals; however, many prisons lack screening capacity. In this study, we aimed …
View article: Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial
Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial Open
Background Accurately identifying COVID-19 episodes was crucial during the pandemic for evaluating interventions. Results from diagnostic tools like PCR, rapid antigen test (RAT) and serology are affected by factors such as timing of tests…
View article: Travel-associated international spread of Oropouche virus beyond the Amazon
Travel-associated international spread of Oropouche virus beyond the Amazon Open
Oropouche virus (OROV), first detected in Trinidad and Tobago in 1955, was historically confined to the Brazilian Amazon Basin. However, since late 2022, an increasing number of OROV cases have been reported across various regions of Brazi…
View article: Immunogenicity and reactogenicity of fractional vs. full booster doses of COVID-19 vaccines: a non-inferiority, randomised, double-blind, phase IV clinical trial in Brazil
Immunogenicity and reactogenicity of fractional vs. full booster doses of COVID-19 vaccines: a non-inferiority, randomised, double-blind, phase IV clinical trial in Brazil Open
Coalition for Epidemic Preparedness Innovations (CEPI)/Sabin Vaccine Institute.
View article: Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response
Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response Open
OBJECTIVES: SARS-CoV-2 nucleocapsid (N) protein antibodies can be used to detect the serological response to natural infection in those previously receiving a COVID-19 spike-based vaccine. Anti-N antibody responses can also be detected in …
View article: A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health
A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health Open
Background/Objectives: Takeda’s tetravalent dengue vaccine TAK-003 has been approved by the Brazilian regulatory agency ANVISA for dengue disease prevention in individuals aged 4 to 60 years. Dourados, in the state of Mato Grosso do Sul, b…
View article: Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination
Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination Open
Objectives Bacille Calmette–Guérin (BCG) vaccination has off‐target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune …
View article: Tuberculosis and the Research Workforce Renewal Crisis in Brazil: How Can We Prevent a Future Without New Researchers?
Tuberculosis and the Research Workforce Renewal Crisis in Brazil: How Can We Prevent a Future Without New Researchers? Open
Tuberculosis (TB) is among the oldest and deadliest infectious diseases, particularly when associated with human immunodeficiency virus (HIV) and antimicrobial resistance. Despite the progress in prevention, diagnosis, and treatment, globa…