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View article: <scp>RAB39B</scp> Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies
<span>RAB39B</span> Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies Open
Parkinson's disease (PD) is a neurodegenerative disorder that may sometimes be caused by deleterious genetic variants. Among them, RAB39B polymorphisms are known as rare causes of early‐onset PD associated with intellectual disability (Wai…
View article: MED13L pathogenic missense variants impair protein stability and interaction, underlying diverse clinical outcomes
MED13L pathogenic missense variants impair protein stability and interaction, underlying diverse clinical outcomes Open
Heterozygous pathogenic variants in the Mediator complex subunit 13-like gene located in the locus 12q21.21 (MED13L) are associated with intellectual disability, developmental delay, and distinctive facial features. While nonsense and fram…
View article: Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1
Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1 Open
View article: A Case of Multiple System Atrophy Associated with a Homozygous Coq2 Mutation (N228s, C.683a>G)
A Case of Multiple System Atrophy Associated with a Homozygous Coq2 Mutation (N228s, C.683a>G) Open
View article: <scp>PARP</scp>‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing <scp>MDA</scp>‐<scp>MB</scp>‐231 Breast Cancer Cells
<span>PARP</span>‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing <span>MDA</span>‐<span>MB</span>‐231 Breast Cancer Cells Open
Background The Ets‐1 transcription factor plays a primordial role in regulating the expression of numerous genes implicated in cancer progression. In a previous study, we revealed that poly(ADP‐ribose) polymerase‐1 (PARP‐1) inhibition by P…
View article: An intrinsically disordered region in MED13 turns Mediator on/off on cue
An intrinsically disordered region in MED13 turns Mediator on/off on cue Open
View article: Assessment of machine‐learning predictions for the Mediator complex subunit <scp>MED25 ACID</scp> domain interactions with transactivation domains
Assessment of machine‐learning predictions for the Mediator complex subunit <span>MED25 ACID</span> domain interactions with transactivation domains Open
The human Mediator complex subunit MED25 binds transactivation domains (TADs) present in various cellular and viral proteins using two binding interfaces, named H1 and H2, which are found on opposite sides of its ACID domain. Here, we use …
View article: Assessment of machine-learning predictions for MED25 ACID domain interactions with transactivation domains
Assessment of machine-learning predictions for MED25 ACID domain interactions with transactivation domains Open
Human Mediator complex subunit MED25 binds transactivation domains (TADs) present in various cellular and viral proteins using two binding interfaces found on opposite sides of its ACID domain, and referenced as H1 and H2. Here, we use and…
View article: Supplementary Figure S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S2 shows the co-occupancy by RXRalpha, RARalpha/gamma and YAP of ALDH1A3 and LGR5 proximal RAREs in control HT29 cells
View article: Supplementary Figure S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S1 identifies YAP/RXRalpha and YAP/RARgamma molecular complexes in HT29-YAPdc cells expressing activated nuclear YAP
View article: Supplementary Figure S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S1 identifies YAP/RXRalpha and YAP/RARgamma molecular complexes in HT29-YAPdc cells expressing activated nuclear YAP
View article: Supplementary Table S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S1 displays the list of antibodies, siRNAs and primers used in the study
View article: Supplementary Figure S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S2 shows the co-occupancy by RXRalpha, RARalpha/gamma and YAP of ALDH1A3 and LGR5 proximal RAREs in control HT29 cells
View article: Data from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Data from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
The mechanisms whereby the Hippo pathway effector YAP regulates cancer cell stemness, plasticity, and chemoresistance are not fully understood. We previously showed that in 5-fluorouracil (5-FU)–resistant colorectal cancer cells, the trans…
View article: Supplementary Figure S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S3 shows the validation of the YAP/RAR-RXR crosstalk in control and YAPdc-RKO colorectal cancer cells.
View article: Data from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Data from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
The mechanisms whereby the Hippo pathway effector YAP regulates cancer cell stemness, plasticity, and chemoresistance are not fully understood. We previously showed that in 5-fluorouracil (5-FU)–resistant colorectal cancer cells, the trans…
View article: Supplementary Table S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S3 (Parts A and B) provides the classification of 115 YAP-binding partners according to several criteria related to the study
View article: Supplementary Table S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S1 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S1 displays the list of antibodies, siRNAs and primers used in the study
View article: Supplementary Table S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S3 (Parts A and B) provides the classification of 115 YAP-binding partners according to several criteria related to the study
View article: Supplementary Table S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S2 presents the detailed proteomics of nuclear YAP-interactome identified in HT29-YAPdc cells
View article: Supplementary Figure S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Figure S3 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Figure S3 shows the validation of the YAP/RAR-RXR crosstalk in control and YAPdc-RKO colorectal cancer cells.
View article: Supplementary Table S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Supplementary Table S2 from Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Open
Supplementary Table S2 presents the detailed proteomics of nuclear YAP-interactome identified in HT29-YAPdc cells
View article: Supplementary Figure 2 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Figure 2 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 202K, Figure S2. Western blot analysis of c-Yes and YAP in human colon cancer cells HT29 and RKO cells treated by oxaliplatin and 5FU.
View article: Supplementary Table 1 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Table 1 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 55K, Table S1. Expression of cell surface stem cell markers in parental HT29 cells, its 5FUresistant 5F7 and 5F31 clonal derivatives, 5FU- and oxaliplatin-resistant HT29FU and HT29OXA subpopulations.
View article: Supplementary Figure Legend from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Figure Legend from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 50K
View article: Supplementary Figure 2 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Figure 2 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 202K, Figure S2. Western blot analysis of c-Yes and YAP in human colon cancer cells HT29 and RKO cells treated by oxaliplatin and 5FU.
View article: Supplementary Methods from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Methods from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 107K
View article: Data from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Data from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
Purpose: Metastasis and drug resistance are the major limitations in the survival and management of patients with cancer. This study aimed to identify the mechanisms underlying HT29 colon cancer cell chemoresistance acquired after s…
View article: Supplementary Figure 1 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Figure 1 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 309K, Figure S1. Expression of cancer stem cell phenotypes in 5FU-resistant 5F7 and 5F31 clones.
View article: Supplementary Figure Legend from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Supplementary Figure Legend from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis Open
PDF file - 50K