Julius Huebl
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View article: Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants Open
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is requi…
View article: Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation
Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation Open
Background Deep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long‐term effects and the safety profile are rare. Objectives We assessed the efficacy and safety of pallidal …
View article: Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients
Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients Open
Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics …
View article: Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients
Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients Open
Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics …
View article: Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single‐Arm, Multicenter Study with a Subsequent Randomized Double‐Blind Crossover ( <scp>STIM‐CP</scp> )
Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single‐Arm, Multicenter Study with a Subsequent Randomized Double‐Blind Crossover ( <span>STIM‐CP</span> ) Open
Background Patients with dyskinetic cerebral palsy are often severely impaired with limited treatment options. The effects of deep brain stimulation (DBS) are less pronounced than those in inherited dystonia but can be associated with favo…
View article: Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease
Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease Open
Deep brain stimulation has local effects on the target structure, but also global effects via distributed brain networks. Horn et al. show that modulating the activity of the subthalamic nucleus in patients with Parkinson’s disease normali…
View article: Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease
Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease Open
Gamma synchronization increases during movement and scales with kinematic parameters. Here, disease-specific characteristics of this synchronization and the dopamine-dependence of its scaling in Parkinson’s disease are investigated. In 16 …
View article: Author response: Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease
Author response: Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Methods and materials References Decision letter Author response Article and author information Metrics Abstract Gamma synchronization increases during movement…
View article: Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson’s disease
Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson’s disease Open
The subthalamic nucleus (STN) occupies a strategic position in the motor network, slowing down responses in situations with conflicting perceptual input. Recent evidence suggests a role of the STN in emotion processing through strong conne…
View article: Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease
Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease Open
Objective Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between os…
View article: Processing of emotional stimuli is reflected by modulations of beta band activity in the subgenual anterior cingulate cortex in patients with treatment resistant depression
Processing of emotional stimuli is reflected by modulations of beta band activity in the subgenual anterior cingulate cortex in patients with treatment resistant depression Open
Deep brain stimulation (DBS) of the subgenual anterior cingulate cortex (sgACC) has emerged as a new therapeutic option in patients with treatment resistant depression (TRD). At the same time, DBS offers a unique opportunity as an innovati…