Julius Jonaitis
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View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system
Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system Open
Inhibitory local interneurons (LNs) play an essential role in sensory processing by refining stimulus representations via a diverse collection of mechanisms. The morphological and physiological traits of individual LN types, as well as the…
View article: Selective life-long suppression of an odor processing channel in response to critical period experience
Selective life-long suppression of an odor processing channel in response to critical period experience Open
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exp…
View article: Steering From the Rear: Coordination of Central Pattern Generators Underlying Navigation by Ascending Interneurons
Steering From the Rear: Coordination of Central Pattern Generators Underlying Navigation by Ascending Interneurons Open
Understanding how animals coordinate movements to achieve goals is a fundamental pursuit in neuroscience. Here we explore how neurons that reside in posterior lower-order regions of a locomotor system project to anterior higher-order regio…
View article: Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila
Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila Open
Sensory systems are dynamically adjusted according to the animal’s ongoing needs by neuromodulators, such as neuropeptides. Neuropeptides are often widely-distributed throughout sensory networks, but it is unclear whether such neuropeptide…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila Open
Original confocal scans for all light microscopy images in the main and supplementary figures of Sizemore et al., 2023. If you make use of this data, please cite: Heterogeneous Receptor Expression Underlies Non-uniform Pep…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in Drosophila Open
Original confocal scans for all light microscopy images in the main and supplementary figures of Sizemore et al., 2023. If you make use of this data, please cite: Heterogeneous Receptor Expression Underlies Non-uniform Pep…
View article: Stimulus-Specific Modulation is Enabled by Differential Serotonin Receptor Expression
Stimulus-Specific Modulation is Enabled by Differential Serotonin Receptor Expression Open
Neural networks must be able to flexibly process information under different conditions. To this end, networks frequently rely on uniform expression of modulatory receptors by distinct classes of neurons to fine tune the computations suppo…
View article: Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in<i>Drosophila</i>
Heterogeneous Receptor Expression Underlies Non-uniform Peptidergic Modulation of Olfaction in<i>Drosophila</i> Open
Sensory systems are dynamically adjusted according to the animal’s ongoing needs by neuromodulators, such as neuropeptides. Although many neuropeptides are often widely-distributed throughout sensory networks, it is unclear whether such ne…
View article: Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the <i>Drosophila</i> larval locomotor network
Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the <i>Drosophila</i> larval locomotor network Open
Using a combination of pharmacology, electrophysiology, and Ca 2+ imaging, we find that signaling through mACh receptors plays a critical role in rhythmogenesis in different regions of the Drosophila larval CNS. mAChR-dependent rhythm gene…
View article: Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit
Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit Open
View article: Localization of muscarinic acetylcholine receptor dependent rhythm generating modules in the<i>Drosophila</i>larval locomotor network
Localization of muscarinic acetylcholine receptor dependent rhythm generating modules in the<i>Drosophila</i>larval locomotor network Open
Mechanisms of rhythm generation have been extensively studied in motor systems that control locomotion over terrain in limbed animals; however, much less is known about rhythm generation in soft-bodied terrestrial animals. Here we explored…
View article: Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit
Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit Open
Typical patterned movements in animals are achieved through combinations of contraction and delayed relaxation of groups of muscles. However, how intersegmentally coordinated patterns of muscular relaxation are regulated by the neural circ…
View article: Probing the interconnectivity of rhythm generating modules in Drosophila melanogaster larvae
Probing the interconnectivity of rhythm generating modules in Drosophila melanogaster larvae Open
"I want to thank Wellcome Trust and Kaunas Industrial Water Supply for the funding which was a huge support for achieving my PhD." -- Acknowledgements
View article: Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster
Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster Open
Alcohol use disorder (AUD) is a major health, social and economic problem for which there are few effective treatments. The opiate antagonist naltrexone is currently prescribed clinically with mixed success. We have used naltrexone in an e…