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View article: Growth of complete ammonia oxidizers on guanidine
Growth of complete ammonia oxidizers on guanidine Open
View article: Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions Open
View article: Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C
Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C Open
Cardiomyopathies, diseases of the heart muscle, are a leading cause of heart failure. An increasing proportion of cardiomyopathies have been associated with specific genetic changes, such as mutations in FLNC , the gene that codes for fila…
View article: FLNC-Associated Myofibrillar Myopathy
FLNC-Associated Myofibrillar Myopathy Open
This new MFM-filaminopathy family confirms that expression of mutant FLNC leads to an adult-onset muscle phenotype with intracellular protein accumulation. Mutant FLNc protein is biochemically compromised and leads to dysregulation …
View article: Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin Open
Sarcomeric proteins FATZ-1 and α-actinin-2 associate in a tight fuzzy complex, which forms phase-separated condensates.
View article: Molecular basis of F-actin regulation and sarcomere assembly via myotilin
Molecular basis of F-actin regulation and sarcomere assembly via myotilin Open
Sarcomeres, the basic contractile units of striated muscle cells, contain arrays of thin (actin) and thick (myosin) filaments that slide past each other during contraction. The Ig-like domain-containing protein myotilin provides structural…
View article: Sarcomeric Protein Fatz Forms a Tight Fuzzy Complex with α-Actinin and Phase-Separates in Vitro
Sarcomeric Protein Fatz Forms a Tight Fuzzy Complex with α-Actinin and Phase-Separates in Vitro Open
View article: Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats Open
MORN (Membrane Occupation and Recognition Nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. Despite this ubiquity, they remain poorly characterised at both a structural and a functio…
View article: Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin
Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin Open
Significance Actin is one of the most abundant proteins in eukaryotic cells. Actin filaments together with a large number of actin-binding proteins are critical players in many cellular functions, ranging from cell motility and muscle cont…
View article: Structural Insights into F-actin Regulation and Sarcomere Assembly via Myotilin
Structural Insights into F-actin Regulation and Sarcomere Assembly via Myotilin Open
View article: Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats Open
MORN (Membrane Occupation and Recognition Nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. Despite this ubiquity, they remain poorly characterised at both a structural and a functio…
View article: High-resolution dimeric crystal structures of wild-type and mutant <i>Aspergillus niger</i> glucose oxidase
High-resolution dimeric crystal structures of wild-type and mutant <i>Aspergillus niger</i> glucose oxidase Open
View article: High-throughput stability screening of integral membrane proteins
High-throughput stability screening of integral membrane proteins Open
Structural analysis has changed the way we look at our world.The foremost technique used in structural analysis is X-ray crystallography.When applied on biological macromolecules the major bottleneck of this method is the production of wel…
View article: Deciphering the BAR code of membrane modulators
Deciphering the BAR code of membrane modulators Open
The BAR domain is the eponymous domain of the "BAR-domain protein superfamily", a large and diverse set of mostly multi-domain proteins that play eminent roles at the membrane cytoskeleton interface. BAR domain homodimers are the functiona…
View article: The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome
The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome Open
To study the mechanisms involved in the maintenance of a linear mitochondrial genome we investigated the biochemical properties of the recombination protein Mgm101 from Candida parapsilosis. We show that CpMgm101 complements defects associ…
View article: Structural Insights into Ca2+-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes
Structural Insights into Ca2+-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes Open