Jully Pires
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View article: Urinary Cystine/Creatinine Concentrations Before and After Castration in Dogs With Suspected Androgen‐Dependent Cystine Urolithiasis
Urinary Cystine/Creatinine Concentrations Before and After Castration in Dogs With Suspected Androgen‐Dependent Cystine Urolithiasis Open
Background Androgen‐dependent cystinuria has been described in intact male dogs. Castration has been recommended to reduce urinary cystine excretion. Hypothesis/Objectives Urinary cystine/creatinine concentration will significantly decreas…
View article: Mesenchymal stem/stromal cell therapy improves immune recovery in a feline model of severe coronavirus infection
Mesenchymal stem/stromal cell therapy improves immune recovery in a feline model of severe coronavirus infection Open
Severe coronavirus infections, including SARS-CoV-2, are marked by systemic inflammation, T-cell exhaustion, lymphopenia, and chronic immune dysfunction, with limited therapeutic options for recovery. Feline infectious peritonitis (FIP), a…
View article: Accidental insulin-induced hypoglycemia in nondiabetic dogs
Accidental insulin-induced hypoglycemia in nondiabetic dogs Open
Purpose: Herein, animal cases of insulin-induced hypoglycemia are presented in nondiabetic patients. We report an outbreak of iatrogenic insulin poisoning in dogs. Methods: Twenty dogs presented peracute clinical signs, and seven were subm…
View article: Assessment of Exenatide Extended‐Release for Maintenance of Diabetic Remission in Cats
Assessment of Exenatide Extended‐Release for Maintenance of Diabetic Remission in Cats Open
Background Insulin‐treated diabetic cats frequently achieve transient remission. The glucagon‐like peptide‐1 receptor agonist, exenatide extended‐release (exenatide‐ER), preserves β cell function in people with type 2 diabetes mellitus (DM…
View article: Open label clinical trial of orally administered molnupiravir as a first‐line treatment for naturally occurring effusive feline infectious peritonitis
Open label clinical trial of orally administered molnupiravir as a first‐line treatment for naturally occurring effusive feline infectious peritonitis Open
Background Before the discovery of effective antiviral drugs, feline infectious peritonitis (FIP) was a uniformly fatal disease of cats. Multiple antiviral treatments have been recognized, but optimization of treatment protocols is needed.…
View article: Evaluation of the efficacy of a live <i>Escherichia coli</i> biotherapeutic product (<scp>asymptomatic bacteriuria</scp><i>E. coli</i> 212)
Evaluation of the efficacy of a live <i>Escherichia coli</i> biotherapeutic product (<span>asymptomatic bacteriuria</span><i>E. coli</i> 212) Open
Background Recurrent bacterial cystitis, often referred to as recurrent urinary tract infection (UTI), can be difficult to manage and alternative treatments are needed. Hypothesis/Objective Intravesicular administration of asymptomatic bac…
View article: Efficacy of Oral Remdesivir Compared to GS-441524 for Treatment of Cats with Naturally Occurring Effusive Feline Infectious Peritonitis: A Blinded, Non-Inferiority Study
Efficacy of Oral Remdesivir Compared to GS-441524 for Treatment of Cats with Naturally Occurring Effusive Feline Infectious Peritonitis: A Blinded, Non-Inferiority Study Open
Nucleoside analogs GS-441524 and remdesivir (GS-5734) are effective in treating cats with feline infectious peritonitis (FIP). However, no studies have compared the efficacy between antiviral medications. The objective of this study was to…
View article: Evaluation of a rapid immunoassay for bacteriuria in dogs
Evaluation of a rapid immunoassay for bacteriuria in dogs Open
Background The ability to detect bacteriuria in dogs with a point‐of‐care test might improve medical care and antimicrobial stewardship. Hypothesis and Objective A rapid immunoassay (RIA; RapidBac) will provide acceptable sensitivity and s…
View article: Evaluation of a machine learning tool to screen for hypoadrenocorticism in dogs presenting to a teaching hospital
Evaluation of a machine learning tool to screen for hypoadrenocorticism in dogs presenting to a teaching hospital Open
Background Dogs with hypoadrenocorticism (HA) have clinical signs and clinicopathologic abnormalities that can be mistaken as other diseases. In dogs with a differential diagnosis of HA, a machine learning model (MLM) has been validated to…
View article: Ultra‐long‐acting recombinant insulin for the treatment of diabetes mellitus in dogs
Ultra‐long‐acting recombinant insulin for the treatment of diabetes mellitus in dogs Open
Background For the treatment of diabetes mellitus (DM) in dogs, novel insulins with decreased injection frequency while maintaining safety and efficacy are desirable. Insulin fused with immunoglobulin‐fragment‐crystallizable (Fc) has an ul…
View article: Day‐to‐day variability of porcine lente, insulin glargine 300 U/<scp>mL</scp> and insulin degludec in diabetic dogs
Day‐to‐day variability of porcine lente, insulin glargine 300 U/<span>mL</span> and insulin degludec in diabetic dogs Open
Background Day‐to‐day variability impacts safety of insulin therapy and the choice of monitoring strategies. Side‐by‐side comparisons of insulin formulations in diabetic dogs are scarce. Hypothesis/Objectives Insulin glargine 300 U/mL (IGl…
View article: An ultra‐long‐acting recombinant insulin for the treatment of diabetes mellitus in cats
An ultra‐long‐acting recombinant insulin for the treatment of diabetes mellitus in cats Open
Background Treatment of diabetes mellitus (DM) in cats typically requires insulin injections q12h‐q24h, posing a major compliance barrier for caregivers. Novel treatments enabling decreased injection frequency while maintaining safety are …
View article: Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus
Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus Open
Diabetes mellitus (DM) is associated with a dysfunctional intestinal barrier and an increased risk for systemic infection and inflammation in people, though the pathogenic mechanisms leading to this are poorly understood. Using a canine mo…
View article: Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations
Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations Open
Background The FreeStyle Libre (Abbott Laboratories) is a flash glucose monitoring system (FGMS) that measures interstitial glucose concentration (IG). The system is factory‐calibrated, easy to use, inexpensive, and could be useful for mon…