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View article: Therapeutic Targeting of the Pentose Phosphate Pathway in Colorectal Cancer Using 6‐Aminonicotinamide and 5‐Fluorouracil
Therapeutic Targeting of the Pentose Phosphate Pathway in Colorectal Cancer Using 6‐Aminonicotinamide and 5‐Fluorouracil Open
Colorectal cancer (CRC) is a significant global health concern with rising incidence and mortality rates. 5‐Fluorouracil (5‐FU) is the standard chemotherapy for CRC but is often constrained by resistance and toxicity, highlighting the need…
View article: Mannose Inhibits the Pentose Phosphate Pathway in Colorectal Cancer and Enhances Sensitivity to 5-Fluorouracil Therapy
Mannose Inhibits the Pentose Phosphate Pathway in Colorectal Cancer and Enhances Sensitivity to 5-Fluorouracil Therapy Open
Colorectal cancer (CRC) is one of the leading cancers and causes of death in patients. 5-fluorouracil (5-FU) is the therapy of choice for CRC, but it exhibits high toxicity and drug resistance. Tumorigenesis is characterized by a deregulat…
View article: EFFECT OF SORAFENIB ON HUMAN COLON CANCER CELLS
EFFECT OF SORAFENIB ON HUMAN COLON CANCER CELLS Open
: Sorafenib, a kinase inhibitor, is among the approved drugs for the treatment of radioactive iodine resistant thyroid carcinoma, primary kidney and liver cancers. Reported targets of Sorafenib include VEGFR, Raf family, and PDGFR belongin…
View article: The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities
The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities Open
Background: Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions. Unlike their normal cell counterparts, tumor cells rely on aerobic…
View article: MORINGA OLEIFERA LEAVES AQUEOUS EXTRACT INDUCE APOPTOSIS IN HT29 CELL LINE
MORINGA OLEIFERA LEAVES AQUEOUS EXTRACT INDUCE APOPTOSIS IN HT29 CELL LINE Open
Moringa oleifera (MO) tree has been recognized for the nutritional and medicinal values, attributing anti-inflammatory, antioxidants, and antidiabetic activities of the alcoholic and/or water extracts to its various parts. Recent research …
View article: Wilson’s disease in Lebanon and regional countries: Homozygosity and hepatic phenotype predominance
Wilson’s disease in Lebanon and regional countries: Homozygosity and hepatic phenotype predominance Open
Findings do not support presence of a founder effect. Clinical and genetic screening is recommended for family members with index patients and unexplained hepatic dysfunction.
View article: Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase
Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase Open
Phytochemicals have been extensively researched for their potential anticancer effects. In previous study, direct exposure of rat liver mitochondria to eugenol main ingredient of clove, uncoupled mitochondria and increased F 0 F 1 ATPase a…
View article: Chemosensitivity of U251 Cells to the Co-treatment of D-Penicillamine and Copper: Possible Implications on Wilson Disease Patients
Chemosensitivity of U251 Cells to the Co-treatment of D-Penicillamine and Copper: Possible Implications on Wilson Disease Patients Open
D-Penicillamine (PA), a copper chelator, and one of the recommended drugs for treatment of Wilson disease (WD) has been reported to worsen the symptoms of patients with neurologic presentations. However, the cause of this paradoxical respo…
View article: The Appearance of a Leptin Effect on Glucose Absorption in Caco2 Cells Depends on Their Differentiation Level
The Appearance of a Leptin Effect on Glucose Absorption in Caco2 Cells Depends on Their Differentiation Level Open
Backdround/Aims: The aim of this work was to study the effect and mechanism of action of leptin added apically, on glucose absorption, using Caco-2 cells as a model. Methods: Cells were grown on inserts and treated with leptin, at differen…