Juming Yan
YOU?
Author Swipe
View article: Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation
Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Open
View article: Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis
Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis Open
Tissue inhibitor of metalloproteinase 1 (TIMP1) has been implicated in prostate cancer (PCa) metastasis. In this study, PC-3M-2B4 cells with TIMP1 knockdown (PC-3M-2B4-shTIMP1) or overexpression (PC-3M-2B4-TIMP1) were generated, and an inv…
View article: Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell Open
View article: Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery Open
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progres…
View article: Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation Open
View article: NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages
NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages Open
Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on macrophages was reported, but the role of NMDAR on macrophage…
View article: Supplementary Figures from Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Supplementary Figures from Control of Metastases via Myeloid CD39 and NK Cell Effector Function Open
Supplementary Figures 1-10 + Legends
View article: Supplementary Figures from Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Supplementary Figures from Control of Metastases via Myeloid CD39 and NK Cell Effector Function Open
Supplementary Figures 1-10 + Legends
View article: Data from Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Data from Control of Metastases via Myeloid CD39 and NK Cell Effector Function Open
Natural killer (NK) cell protection from tumor metastases is a critical feature of the host immune response to cancer, but various immunosuppression mechanisms limit NK cell effector function. The ectoenzyme, CD39, expressed on tumor-infil…
View article: Data from Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Data from Control of Metastases via Myeloid CD39 and NK Cell Effector Function Open
Natural killer (NK) cell protection from tumor metastases is a critical feature of the host immune response to cancer, but various immunosuppression mechanisms limit NK cell effector function. The ectoenzyme, CD39, expressed on tumor-infil…
View article: Supplementary Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
Supplementary Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1 Open
Supplementary text and figures
View article: Supp. Fig. 1 from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Supp. Fig. 1 from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Supp Fig. 1
View article: Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Open
The glutamate metabotropic receptor 4 (GRM4) locus is linked to susceptibility to human osteosarcoma, through unknown mechanisms. We show that Grm4−/− gene–targeted mice demonstrate accelerated radiation-induced tu…
View article: Supplementary Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Supplementary Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Open
Figures S1-S16 Tables S1 to S2
View article: Supp. Fig. 1 from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Supp. Fig. 1 from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Supp Fig. 1
View article: Supplementary Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
Supplementary Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1 Open
Supplementary text and figures
View article: Supplementary Figure Legend from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Supplementary Figure Legend from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Supplementary Figure Legends
View article: Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1 Open
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I–related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear, and to date no study has evaluated these cells in v…
View article: Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Open
The glutamate metabotropic receptor 4 (GRM4) locus is linked to susceptibility to human osteosarcoma, through unknown mechanisms. We show that Grm4−/− gene–targeted mice demonstrate accelerated radiation-induced tu…
View article: Supplementary Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Supplementary Data from Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Open
Figures S1-S16 Tables S1 to S2
View article: Data from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Data from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Tumor-induced immunosuppression is mediated through various mechanisms including engagement of immune checkpoint receptors on effector cells, function of immunoregulatory cells such as regulatory T cells and myeloid-derived suppressor cell…
View article: Supplementary Figure Legend from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Supplementary Figure Legend from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Supplementary Figure Legends
View article: Data from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23
Data from Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 Open
Tumor-induced immunosuppression is mediated through various mechanisms including engagement of immune checkpoint receptors on effector cells, function of immunoregulatory cells such as regulatory T cells and myeloid-derived suppressor cell…
View article: Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
Data from MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1 Open
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I–related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear, and to date no study has evaluated these cells in v…
View article: The role of glutamate receptors in the regulation of the tumor microenvironment
The role of glutamate receptors in the regulation of the tumor microenvironment Open
Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression. Several factors can affect the expression of glutamate receptors, playing either…
View article: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation Open
View article: MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1
MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1 Open
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I–related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear, and to date no study has evaluated these cells in vivo…
View article: Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Open
The glutamate metabotropic receptor 4 (GRM4) locus is linked to susceptibility to human osteosarcoma, through unknown mechanisms. We show that Grm4−/− gene–targeted mice demonstrate accelerated radiation-induced tumor development to an ext…
View article: Timing of neoadjuvant immunotherapy in relation to surgery is crucial for outcome
Timing of neoadjuvant immunotherapy in relation to surgery is crucial for outcome Open
Adjuvant immunotherapies targeting CTLA4 or PD-1 recently demonstrated efficacy in the treatment of earlier stages of human cancer. We previously demonstrated using mouse spontaneous metastasis models that neoadjuvant immunotherapy and sur…
View article: B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells Open
Cancer stem cells (CSCs) have been implicated in metastasis, relapse, and therapeutic resistance of cancer, so successful cancer therapy may therefore require the development of drugs against CSCs or combining anti-CSCs drugs with conventi…