Jun Adachi
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View article: Serum fucosylated receptor expression‑enhancing protein 5 as a biomarker for early stage pancreatic cancer
Serum fucosylated receptor expression‑enhancing protein 5 as a biomarker for early stage pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is a leading cause of cancer mortality. Early diagnosis is difficult due to the anatomical characteristics of the pancreas, which is a long and thin organ located dorsal to t…
View article: Elevated ITGAX/CD11c in CSF-Derived Extracellular Vesicles Reflects Disability Progression in Multiple Sclerosis
Elevated ITGAX/CD11c in CSF-Derived Extracellular Vesicles Reflects Disability Progression in Multiple Sclerosis Open
Our findings suggest that CSF-derived EVs reflect immunologic changes in MS and other neuroimmune diseases. In addition, these results raise the possibility that changing in myeloid cells and lymphocytes may also play a role in the pathoge…
View article: Brexpiprazole's impacts on patients and caregivers in agitation in Alzheimer's dementia
Brexpiprazole's impacts on patients and caregivers in agitation in Alzheimer's dementia Open
INTRODUCTION We evaluated the impacts of brexpiprazole treatment on patient neuropsychiatric symptoms and caregiver distress in Japanese patients with agitation in Alzheimer's dementia (AAD). METHODS In a phase 2/3 multicenter, double‐blin…
View article: Establishment of enterotype-specific antibodies for various diagnostic systems
Establishment of enterotype-specific antibodies for various diagnostic systems Open
This study demonstrates that monoclonal antibodies can be developed to targeting specific gut bacteria prevalent in the Japanese population and the potential for creating a novel diagnostic system using these antibodies. In this study, we …
View article: <scp>EIF2S1</scp> in Urinary Extracellular Vesicles as a Novel Diagnostic Marker for Bladder Cancer
<span>EIF2S1</span> in Urinary Extracellular Vesicles as a Novel Diagnostic Marker for Bladder Cancer Open
Background Urinary extracellular vesicles (uEVs), directly secreted from bladder cancer (BCa) cells, harbor potential for biomarker discovery. Methods We performed proteomic analysis to explore and validate uEV‐based diagnostic markers for…
View article: Protein profiling of extracellular vesicles from the cerebrospinal fluid of patients with multiple sclerosis
Protein profiling of extracellular vesicles from the cerebrospinal fluid of patients with multiple sclerosis Open
Background Extracellular vesicles (EVs) are membrane-bound particles that are released into the extracellular space and are thought to play a role in the pathogenesis of neuroinflammation and neurodegeneration. Nevertheless, the precise ro…
View article: Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases
Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases Open
The resistance of colorectal cancer liver metastases (CRLMs) to 5-fluorouracil (5-FU) chemotherapy remains a significant global health challenge. We investigated the phosphoproteomic dynamics of serial tissue sections obtained from initial…
View article: Priming Epigenetic Landscape at Gene Promoters through Transcriptional Activation in Mammalian Germ Cells
Priming Epigenetic Landscape at Gene Promoters through Transcriptional Activation in Mammalian Germ Cells Open
Summary In mammalian germ cells, a cycle of erasing and resetting epigenetic information is crucial for sex-specific gametogenesis and early embryogenesis. Specific chromatin states at promoters allow genes to be expressed at the appropria…
View article: Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study
Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study Open
INTRODUCTION We evaluated the efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer's dementia (AAD) in Japanese patients. METHODS This was a phase 2/3 multicenter, randomized, double‐blind, placebo‐controlled, p…
View article: Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment
Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment Open
There are only a few effective molecular targeted agents for advanced unresectable or recurrent advanced gastric cancer (AGC), which has a poor prognosis with a median survival time of less than 14 months. Focusing on phosphorylation signa…
View article: QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism
QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism Open
Introduction Campylobacter spp. are a public health concern, yet there is still no effective vaccine or medicine available. Methods Here, we developed a Campylobacter jejuni -specific antibody and found that it targeted a menaquinol cytoch…
View article: SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis
SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis Open
Progressive pulmonary fibrosis (PPF), defined as the worsening of various interstitial lung diseases (ILDs), currently lacks useful biomarkers. To identify novel biomarkers for early detection of patients at risk of PPF, we performed a pro…
View article: Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD
Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD Open
Background: There is a need for novel noninvasive markers for metabolic dysfunction–associated steatotic liver disease (MASLD) to stratify patients at high risk for liver-related events including liver cancer and decompensation. In the pre…
View article: Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology
Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology Open
Novel BMs such as Gal10 from serum EVs reflect disease pathophysiology in BA and may represent a new target for liquid biopsy approaches.
View article: Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer
Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer Open
Phosphoproteomic analysis may help elucidate the mechanisms of resistance to molecular-targeted therapies in lung cancer. Mutual phosphorylation of FAK and Src is involved in osimertinib resistance. Thus, FAK and Src inhibition may be nove…
View article: Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain Open
Astrocytes interact with not only synapses but also brain blood vessels through perivascular astrocyte endfeet (PV-AEF) to form the neurovascular unit (NVU). However, PV-AEF components have not been fully identified. Here, we biochemically…
View article: Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients
Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients Open
Medical information is valuable information obtained from humans regarding the phenotype of diseases. Omics data is informative to understand diseases at biomolecular level. We aimed to detect patient stratification patterns in a data-driv…
View article: Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure
Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure Open
NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' function in controlling gene expression remains elusive. Here, we d…
View article: In‐depth proteomics reveals the characteristic developmental profiles of early lung adenocarcinoma with epidermal growth factor receptor mutation
In‐depth proteomics reveals the characteristic developmental profiles of early lung adenocarcinoma with epidermal growth factor receptor mutation Open
Introduction Lung adenocarcinoma progresses stepwise from atypical adenomatous hyperplasia to adenocarcinoma in situ (AIS), followed by minimally invasive adenocarcinoma (MIA), and then obvious invasive adenocarcinoma. In this study, we ex…
View article: Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer
Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer Open
The phosphoproteomics landscape of 35 CRC cell lines revealed unique molecular characteristics of KRAS-mutant cells.Integrated analysis with gene-dependency data identified vulnerability signals in KRAS-mutant cancers.
View article: Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines
Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines Open
Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the objective response rate to apatinib was low. It remains u…
View article: Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment
Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment Open
While topical corticosteroid (TCS) treatment is widely used for many skin diseases, it can trigger adverse side effects, and some of such effects can last for a long time after stopping the treatment. However, molecular changes induced by …
View article: Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19 Open
Background The coronavirus disease 2019 (COVID-19) pandemic is widespread; however, accurate predictors of refractory cases have not yet been established. Circulating extracellular vesicles, involved in many pathological processes, are ide…