Jun Yin
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View article: Alkaloids with cytotoxic activities from Zanthoxylum nitidum
Alkaloids with cytotoxic activities from Zanthoxylum nitidum Open
Two previously undescribed alkaloids, 8-O-demethylmaclekarpine D (1) and zanthonitine (2), along with a pair of inseparable rotamers, 4-hydroxyl-beecheyamide (3a) and (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-methoxyphenethyl)-N-methylacrylam…
View article: Exploration of the Mechanism of Anlotinib in Reversing PD-1 Immunotherapy Resistance: Insights from Single-cell Sequencing
Exploration of the Mechanism of Anlotinib in Reversing PD-1 Immunotherapy Resistance: Insights from Single-cell Sequencing Open
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have revolutionized cancer therapy, yet primary and acquired resistance remain significant clinical challenges. Dysregulated angiogenesis fosters the formation of an immunosu…
View article: Careful Queries, Credible Results: Teaching RAG Models Advanced Web Search Tools with Reinforcement Learning
Careful Queries, Credible Results: Teaching RAG Models Advanced Web Search Tools with Reinforcement Learning Open
Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating up-to-date external knowledge, yet real-world web environments present unique challenges. These limitations manifest as two key challenges: pervasive…
View article: Morphological and molecular evidence suggests that Indosasa gigantea and Acidosasa glauca (Poaceae, Bambusoideae, Arundinarieae) are conspecific
Morphological and molecular evidence suggests that Indosasa gigantea and Acidosasa glauca (Poaceae, Bambusoideae, Arundinarieae) are conspecific Open
Indosasa gigantea is a bamboo with great economical value, but its generic designation has been controversial for a long time. This study aims to ascertain whether I. gigantea belongs to Indosasa or Acidosasa , based on morphological and m…
View article: Rapid Classification and Identification of Chemical Compounds and Semi-Quantitative Metabolism of Huangkui Capsules and the Protective Effects of Its Quercetin Derivatives against Tacrolimus-Induced HK-Cell Reduction
Rapid Classification and Identification of Chemical Compounds and Semi-Quantitative Metabolism of Huangkui Capsules and the Protective Effects of Its Quercetin Derivatives against Tacrolimus-Induced HK-Cell Reduction Open
Objective: The study aimed to establish an effective strategy for systematically characterizing and verifying compounds in Huangkui capsules (HKCs). Materials and Methods: An ultrahigh-performance liquid chromatography quadrupole time-of-f…
View article: A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages Open
Background and Purpose Because of the absence of effective therapies for metabolic dysfunction‐associated steatohepatitis (MASH), there is a rising interest in fibroblast growth factor 21 (FGF21) analogues due to their potential anti‐fibro…
View article: Bergamot regulates oxidized low density lipoprotein induced inflammation and foam cell formation of human umbilical vein endothelial cells by regulating SIRT1/NF κB pathway
Bergamot regulates oxidized low density lipoprotein induced inflammation and foam cell formation of human umbilical vein endothelial cells by regulating SIRT1/NF κB pathway Open
Purpose: To investigate the effects of bergamot (BGM) on the progression of atherosclerosis, and to unravel the mechanism of action. Methods: Oxidized low-density lipoprotein (Ox-LDL)-induced HUVECs were used as an in vitro model of athero…
View article: Antiproliferative, apoptosis-inducing, and <i>GSTP1</i> demethylation activities of Ellagitannins isolated from <i>Cornus alba</i> L.
Antiproliferative, apoptosis-inducing, and <i>GSTP1</i> demethylation activities of Ellagitannins isolated from <i>Cornus alba</i> L. Open
This study aimed to prove the prostate cancer chemopreventive activity of compounds isolated from CA. We evaluated these compounds using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and evaluated their NF-κB…
View article: Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA
Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA Open
Triple-negative breast cancer (TNBC) represents the most challenging subtype of breast cancer. Studies have implicated an upregulation of lipid synthesis pathways in the initiation and progression of TNBC. Targeting lipid synthesis pathway…
View article: Chemopreventive Activity of Ellagitannins from Acer pseudosieboldianum (Pax) Komarov Leaves on Prostate Cancer Cells
Chemopreventive Activity of Ellagitannins from Acer pseudosieboldianum (Pax) Komarov Leaves on Prostate Cancer Cells Open
Several studies have shown that compounds from Acer pseudosieboldianum (Pax) Komarov leaves (APL) display potent anti-oxidative, anti-inflammatory, and anti-proliferative activities. Prostate cancer (PCa) is the most common cancer among ol…
View article: The Functional Roles of ISG15/ISGylation in Cancer
The Functional Roles of ISG15/ISGylation in Cancer Open
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquiti…
View article: Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy
Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy Open
Background and purpose Multidrug resistance (MDR) is a major obstacle to the successful treatment of cancer. Ample evidence shows that ATP‐binding cassette (ABC) transporters and high‐energy states in cells are linked to cancer drug resist…
View article: Alnus sibirica Compounds Exhibiting Anti-Proliferative, Apoptosis-Inducing, and GSTP1 Demethylating Effects on Prostate Cancer Cells
Alnus sibirica Compounds Exhibiting Anti-Proliferative, Apoptosis-Inducing, and GSTP1 Demethylating Effects on Prostate Cancer Cells Open
Alnus sibirica (AS) is distributed in Korea, Japan, China, and Russia and has reported anti-oxidant, anti-inflammatory, and reducing activities on atopic dermatitis-like skin lesions, along with other beneficial health properties. In the p…
View article: Inhibitory Activities of Dimeric Ellagitannins Isolated from Cornus alba on Benign Prostatic Hypertrophy
Inhibitory Activities of Dimeric Ellagitannins Isolated from Cornus alba on Benign Prostatic Hypertrophy Open
Benign prostatic hypertrophy (BPH) is an intractable chronic inflammatory disease. We studied the efficacy of two ellagitannins, namely camptothin B (1) and cornusiin A (2) that were isolated from Cornus alba (CA) for the treatment of BPH,…
View article: Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition
Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition Open
Quercus mongolica (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne …
View article: Anti-Inflammatory Effects of Phenolic Compounds Isolated from Quercus Mongolica Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells
Anti-Inflammatory Effects of Phenolic Compounds Isolated from Quercus Mongolica Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells Open
Quercus mongolica Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (1–6) isolated from QM on the produ…
View article: <p>FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway</p>
FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway Open
Objective: This study aimed to investigate the role of fibroblast growth factor-5 (FGF5) in osteosarcoma (OS) and explore the potential mechanisms. Methods: OS gene expression data was downloaded from the Gene Expression Omnibus (GEO; GSE1…
View article: Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of Alnus sibirica
Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of Alnus sibirica Open
Alnus sibirica (AS) is geographically distributed in Korea, Japan, Northeast China, and Russia. Various anti-oxidant, anti-inflammation, anti-atopic dermatitis and anti-cancer biological effects of AS have been reported. Enzymatic hydrolys…
View article: A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway
A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway Open
Background and Purpose Non‐alcoholic steatohepatitis (NASH) is the most severe form of non‐alcoholic fatty liver disease and is a serious public health problem around the world. There are currently no approved treatments for NASH. FGF21 ha…
View article: Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica
Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica Open
Phytochemical isolation of fermented Alnus sibirica (FAS) which was produced by using Lactobacillus plantarum subsp. argentoratensis, exhibited multiple and different composition compared with the original plant. Anti-allergic contact derm…
View article: Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis
Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis Open
Fermentation of Alnus sibirica (AS) stems using Lactobacillus plantarum subsp. argentoratensis was conducted and three compounds isolated from the Alnus species were identified for the first time, 7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl…
View article: Time- and NADPH-Dependent Inhibition on CYP3A by Gomisin A and the Pharmacokinetic Interactions between Gomisin A and Cyclophosphamide in Rats
Time- and NADPH-Dependent Inhibition on CYP3A by Gomisin A and the Pharmacokinetic Interactions between Gomisin A and Cyclophosphamide in Rats Open
The traditional Chinese medicine Schisandra chinensis has remarkable protective effects against chemical-induced toxicity. Cyclophosphamide (CTX), in spite advances in chemotherapy and immunosuppressive regimes, is prone to cause severe to…
View article: AP2/ERF Transcription Factor, Ii049, Positively Regulates Lignan Biosynthesis in Isatis indigotica through Activating Salicylic Acid Signaling and Lignan/Lignin Pathway Genes
AP2/ERF Transcription Factor, Ii049, Positively Regulates Lignan Biosynthesis in Isatis indigotica through Activating Salicylic Acid Signaling and Lignan/Lignin Pathway Genes Open
Lignans, such as lariciresinol and its derivatives, have been identified as effective antiviral ingredients in Isatis indigotica. Evidence suggests that the APETALA2/ethylene response factor (AP2/ERF) family might be related to the biosynt…
View article: Anti-Inflammatory and Anti-Urolithiasis Effects of Polyphenolic Compounds from Quercus gilva Blume
Anti-Inflammatory and Anti-Urolithiasis Effects of Polyphenolic Compounds from Quercus gilva Blume Open
Quercus gilva Bume (QGB, family Fagaceae) is a tall evergreen oak species tree that grows in warm temperate regions in Korea, Japan, China and Taiwan. Quercus plants have long been the basis of traditional medicines. Their clinical benefit…