Jun Itami
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View article: Development and validation of a prognostic nomogram for survival in patients with brain metastases from colorectal cancer
Development and validation of a prognostic nomogram for survival in patients with brain metastases from colorectal cancer Open
Brain metastases from colorectal cancer are rare but carry a dismal prognosis. This study aimed to develop and externally validate a prognostic model for individualized survival prediction in affected patients. The model was constructed us…
View article: Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy
Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy Open
View article: Comparison of dose distribution with and without reflecting heterogeneous boron distribution using 18F-BPA positron emission tomography in boron neutron capture therapy
Comparison of dose distribution with and without reflecting heterogeneous boron distribution using 18F-BPA positron emission tomography in boron neutron capture therapy Open
This study investigated the dosimetric impact of implementing heterogeneous boron distribution into dose evaluations on tumors in BNCT. The study involved 27 patients who underwent 18F-BPA PET/CT scans. Dose evaluations were per…
View article: Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy
Efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for head and neck cancer recurrence after radiotherapy Open
Background To evaluate the efficacy and safety of diffusing alpha-emitter radiation therapy (DaRT) for recurrent head and neck cancer (rHNC) after radiotherapy. Methods This study was a multicenter prospective clinical trial. Eligibility c…
View article: Boron neutron capture therapy for cutaneous angiosarcoma and malignant melanoma: First in-human phase I clinical trial
Boron neutron capture therapy for cutaneous angiosarcoma and malignant melanoma: First in-human phase I clinical trial Open
BNCT with a dose of 18 Gy-Eq is a feasible treatment option, demonstrating a favorable safety profile and a high response rate in patients with primary or recurrent angiosarcoma or malignant melanoma of the skin.
View article: A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target
A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target Open
View article: Editorial Board
Editorial Board Open
View article: Editorial Board
Editorial Board Open
View article: Editorial Board
Editorial Board Open
View article: Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐<sup>18</sup>F‐fluoro‐phenylalanine accumulation in humans
Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐<sup>18</sup>F‐fluoro‐phenylalanine accumulation in humans Open
Background The correlation between L‐type amino acid transporter 1 (LAT1) expression and 4‐borono‐2‐ 18 F‐fluoro‐phenylalanine ( 18 F‐FBPA) accumulation in humans remains unclear. This study aimed to investigate the correlation between LAT…
View article: Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient
Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient Open
This study reports the first patient treatment for cutaneous malignant melanoma using a linear accelerator-based boron neutron capture therapy (BNCT) system. A single-center open-label phase I clinical trial had been conducted using the sy…
View article: Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 420
Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 420 Open
In the original publication [...]
View article: Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target
Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target Open
This study aimed to quantify the relative biological effectiveness (RBE) for epithermal neutron beam contaminated with fast neutrons in the accelerator-based boron neutron capture therapy (BNCT) system coupled to a solid-state lithium targ…
View article: Prognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer
Prognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer Open
Background Treatment of brain metastases (BMs) from colorectal cancer (CRC) has transitioned with the expansion of indications for stereotactic radiotherapy. Our study aimed to assess changes in prognosis and prognostic factors associated …
View article: Treatment planning comparison of high-dose-rate brachytherapy vs. robotic and conventional stereotactic body radiotherapy for ultrahypofractionated treatment of prostate cancer
Treatment planning comparison of high-dose-rate brachytherapy vs. robotic and conventional stereotactic body radiotherapy for ultrahypofractionated treatment of prostate cancer Open
HDR-BT could administer a higher dose to the PTV and a lower dose to the bladder and rectum, at the cost of a slightly higher dose to the urethra compared with SBRT.
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Editorial Board Open
View article: Impact of interstitial lung abnormality on survival after adjuvant durvalumab with chemoradiotherapy for locally advanced non-small cell lung cancer
Impact of interstitial lung abnormality on survival after adjuvant durvalumab with chemoradiotherapy for locally advanced non-small cell lung cancer Open
Pretreatment ILA, adenocarcinoma, and performance status may have an impact on OS of LA-NSCLC patients receiving CCRT plus durvalumab.
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Editorial Board Open
View article: Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer
Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer Open
The effectiveness of HBT were demonstrated by a prospective clinical study. Because the dose goal determined in the protocol was lower than 85 Gy, there is room in improvement for local control. A higher dose might have been needed for tum…
View article: Analyzing spatial distribution between 18F-fluorodeoxyglucose and 18F-boronophenylalanine positron emission tomography to investigate selection indicators for boron neutron capture therapy
Analyzing spatial distribution between 18F-fluorodeoxyglucose and 18F-boronophenylalanine positron emission tomography to investigate selection indicators for boron neutron capture therapy Open
View article: Technical Note: High-Dose-Rate Interstitial Brachytherapy for Pelvic Sidewall Recurrence Using Intraperitoneal Spacers
Technical Note: High-Dose-Rate Interstitial Brachytherapy for Pelvic Sidewall Recurrence Using Intraperitoneal Spacers Open
The management of pelvic recurrence after hysterectomy depends on whether the patient has previously received pelvic irradiation and whether the recurrence site is pelvic central or pelvic sidewall. The 2022 National Comprehensive Cancer N…
View article: Functional peptide-mediated plastid transformation in tobacco, rice, and kenaf
Functional peptide-mediated plastid transformation in tobacco, rice, and kenaf Open
In plant engineering, plastid transformation is more advantageous than nuclear transformation because it results in high levels of protein expression from multiple genome copies per cell and is unaffected by gene silencing. The common plas…
View article: Technical report: a high-dose-rate interstitial brachytherapy boost for residual sinonasal undifferentiated carcinoma
Technical report: a high-dose-rate interstitial brachytherapy boost for residual sinonasal undifferentiated carcinoma Open
Sinonasal undifferentiated carcinoma (SNUC) is a highly aggressive and uncommon neoplasm that arises from the mucosa of the nasal cavity or paranasal sinuses. The multidisciplinary approach that includes surgery, radiation therapy (RT), an…
View article: Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia
Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia Open
View article: Practical guidelines of online MR-guided adaptive radiotherapy
Practical guidelines of online MR-guided adaptive radiotherapy Open
The first magnetic resonance (MR)-guided radiotherapy system in Japan was installed in May 2017. Implementation of online MR-guided adaptive radiotherapy (MRgART) began in February 2018. Online MRgART offers greater treatment accuracy owin…
View article: Clinical impact of p16 positivity in nasopharyngeal carcinoma
Clinical impact of p16 positivity in nasopharyngeal carcinoma Open
Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients. Materials and Methods…
View article: Non-Robustness of Ang’s Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients
Non-Robustness of Ang’s Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients Open
Background: Validity of the risk classification by Ang for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) remains to be studied in the patients treated by modalities other than chemoradiotherapy and in Jap…
View article: Large volume was associated with increased risk of acute non-hematologic adverse events in the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer: preliminary results of prospective phase I/II clinical trial
Large volume was associated with increased risk of acute non-hematologic adverse events in the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer: preliminary results of prospective phase I/II clinical trial Open
Objective This is the preliminary results of a multi-center prospective clinical trial evaluating the feasibility of the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer. Methods Patients with FIG…
View article: An Asian multi-national multi-institutional retrospective study comparing intracavitary versus the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical carcinoma
An Asian multi-national multi-institutional retrospective study comparing intracavitary versus the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical carcinoma Open
This study is an international multi-institutional retrospective study comparing the clinical outcomes between intracavitary brachytherapy (ICBT) and the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced cer…
View article: Prognostic factor analysis of definitive radiotherapy using intensity-modulated radiation therapy and volumetric modulated arc therapy with boluses for scalp angiosarcomas
Prognostic factor analysis of definitive radiotherapy using intensity-modulated radiation therapy and volumetric modulated arc therapy with boluses for scalp angiosarcomas Open