Jie Jun Wong
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View article: Advancing Cardiovascular Sciences in Ageing for Cardiovascular Longevity Through Transformation and Implementation
Advancing Cardiovascular Sciences in Ageing for Cardiovascular Longevity Through Transformation and Implementation Open
Population ageing and the rise in age-related cardiovascular disease are major sources of healthcare, societal and economic stress worldwide. Cardiovascular disease often coincides with declines in other organ systems, resulting in functio…
View article: Addressing Frailty in Cardiology
Addressing Frailty in Cardiology Open
Distinct barriers to frailty implementation exist at multiple levels, including gaps in provider expertise, insufficient support, and resource constraints that limit adequate frailty care provision. To address the diverse needs of stakehol…
View article: Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults
Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults Open
View article: Effect of Frailty on Cardiovascular Clinical Trials
Effect of Frailty on Cardiovascular Clinical Trials Open
While frailty prognosticated a higher risk of CV events and mortality, frailty did not reduce treatment efficacy. CV trial interventions appear beneficial even in the frailest group.
View article: 71397 | Transcatheter Aortic Valve Reintervention: Long-Term Outcomes in an Asian Cohort
71397 | Transcatheter Aortic Valve Reintervention: Long-Term Outcomes in an Asian Cohort Open
View article: Periprocedural care for frail older patients with aortic stenosis undergoing transcatheter aortic valve replacement
Periprocedural care for frail older patients with aortic stenosis undergoing transcatheter aortic valve replacement Open
View article: Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk
Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk Open
Aims Traditional risk factors do not fully characterize cardiovascular aging and are less helpful in assessing sex differences in cardiovascular risk. Using a novel cardiovascular magnetic resonance (CMR) method, we determined sex differen…
View article: Atherosclerotic cardiovascular disease in aging and the role of advanced cardiovascular imaging
Atherosclerotic cardiovascular disease in aging and the role of advanced cardiovascular imaging Open
Aging and inflammation are key drivers in the pathogenesis of cardiovascular disease. Aging is characterized by chronic, systemic, dysregulated inflammation and dysfunctional immune responses ― termed inflammaging ― that give rise to cumul…
View article: Cracking the Code of Coronary Calcium: One-year Clinical Outcomes of Intravascular Lithotripsy in All-comers and Two Complex Cohorts
Cracking the Code of Coronary Calcium: One-year Clinical Outcomes of Intravascular Lithotripsy in All-comers and Two Complex Cohorts Open
Background: Severe coronary calcifications are commonly encountered in real-world populations and in left main (LM) disease, heightening complication risks including stent underexpansion. Although intravascular lithotripsy (IVL) appears sa…
View article: Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial
Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial Open
Background We previously reported changes in the serum metabolome associated with impaired myocardial relaxation in an asymptomatic older community cohort. In this prospective parallel-group randomized control pilot trial, we subjected com…
View article: RotaTripsy Risk and Rewards: Findings from a Registry of Patients Undergoing Combined Rotational Atherectomy and Intravascular Lithotripsy
RotaTripsy Risk and Rewards: Findings from a Registry of Patients Undergoing Combined Rotational Atherectomy and Intravascular Lithotripsy Open
Background: Heavily calcified coronary artery lesions are a therapeutic challenge for interventional cardiologists worldwide. Recently, RotaTripsy has gained popularity as a calcium modification technique prior to stent implantation. In th…
View article: Current frailty knowledge, awareness, and practices among physicians following the 2022 European consensus document on Frailty in Cardiology
Current frailty knowledge, awareness, and practices among physicians following the 2022 European consensus document on Frailty in Cardiology Open
Aims Aging-related cardiovascular disease and frailty burdens are anticipated to rise with global aging. In response to directions from major cardiovascular societies, we investigated frailty knowledge, awareness, and practices among cardi…
View article: Short- and Long-term Clinical Outcomes of Balloon-expandable Versus Self-expanding Valves in Patients Undergoing Transcatheter Aortic Valve Replacement: A Meta-analysis
Short- and Long-term Clinical Outcomes of Balloon-expandable Versus Self-expanding Valves in Patients Undergoing Transcatheter Aortic Valve Replacement: A Meta-analysis Open
Background: Distinct clinical differences exist between balloon-expandable valves (BEVs) and self-expanding valves (SEVs) used in transcatheter aortic valve replacement (TAVR) for aortic stenosis. However, randomised data on comparative ou…
View article: Distinct gut microbiota composition among older adults with myocardial ageing
Distinct gut microbiota composition among older adults with myocardial ageing Open
Changes in cardiac structure and function occur with ageing and may lead towards ageing-related cardiovascular disease.1 Recent explorations into intestinal microbiota have provided important insights into shifts in microbial composition t…
View article: Coronary Intravascular Lithotripsy Versus Rotational Atherectomy in an Asian Population: Clinical Outcomes in Real-World Patients
Coronary Intravascular Lithotripsy Versus Rotational Atherectomy in an Asian Population: Clinical Outcomes in Real-World Patients Open
These findings represent our initial IVL experience in a high-risk, real-world cohort. Although the event rate in the IVL arm was numerically higher compared to RA, the small numbers and retrospective nature of this study preclude definiti…