Jun Soo Kwon
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View article: Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis
Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis Open
Predicting treatment resistance from the first stage of psychosis aids in personalized treatment, promotes a better prognosis, and contributes to healthcare cost savings. Currently, no biomarker accurately predicts treatment resistance in …
View article: Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program
Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program Open
This paper presents the recruitment sources of clinical high-risk (CHR) and community controls (CC) from the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program, which aims to study various clinical variables and biomarkers …
View article: Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program
Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program Open
View article: The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Open
Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medica…
View article: Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program
Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program Open
View article: Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample Open
View article: The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open
View article: Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program
Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program Open
This paper focuses on the baseline clinical characterization of the participants in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program. The AMP SCZ program is designed to investigate a wide array of clinical variables a…
View article: Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction
Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction Open
N-methyl-D-aspartate receptor (NMDAR) hypofunction is linked to schizophrenia, but prevailing models centered on reduced number and activity of inhibitory interneurons and the resulting excitation-inhibition (E-I) imbalance do not explain …
View article: Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium
Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to the maintenance of obsessions and compulsions. This mega-analysis investigates neura…
View article: Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative
Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative Open
View article: Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative
Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative Open
Speech-based detection of early psychosis is progressing at a rapid pace. Within this evolving field, the Accelerating Medicines Partnership® in Schizophrenia (AMP® SCZ) is uniquely positioned to deepen our understanding of how language an…
View article: Premorbid functioning trajectories and the one-year course of cognitive performance in first-episode psychosis: a cluster analysis in PSYSCAN
Premorbid functioning trajectories and the one-year course of cognitive performance in first-episode psychosis: a cluster analysis in PSYSCAN Open
View article: Multi-view-guided Passage Reranking with Large Language Models
Multi-view-guided Passage Reranking with Large Language Models Open
Recent advances in large language models (LLMs) have shown impressive performance in passage reranking tasks. Despite their success, LLM-based methods still face challenges in efficiency and sensitivity to external biases. (1) Existing mod…
View article: Mismatch Negativity in Subjects at Clinical High Risk for Psychosis: No Evidence of Progressive Decline
Mismatch Negativity in Subjects at Clinical High Risk for Psychosis: No Evidence of Progressive Decline Open
Duration‐deviant mismatch negativity has been investigated as a potential biomarker for predicting early psychosis clinical outcomes. Although progressive mismatch negativity changes have been linked to neurodegeneration and cognitive decl…
View article: Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome
Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome Open
View article: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium
Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during execut…
View article: White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients
White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients Open
Objective The superior longitudinal fasciculus (SLF) is a white matter (WM) bundle connecting the frontal and parietal lobes. SLF subdivisions have distinct functions (e.g., attention, working memory, and language processing), and abnormal…
View article: Ten guidelines for a healthy life: Korean Medical Association Statement (2017)
Ten guidelines for a healthy life: Korean Medical Association Statement (2017) Open
View article: Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long COVID or Post-COVID syndrome
Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long COVID or Post-COVID syndrome Open
Background The C19-YRS was the first condition-specific scale for Long COVID/Post-COVID syndrome. Although the original C19-YRS evolved to the modified version (C19-YRSm) based on psychometric evidence, clinical content relevance and feedb…
View article: Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder Open
Studies of brain morphology in mental illness often incompletely characterize structural variation, focusing on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder …
View article: Relationships Among Impulsivity, Keystroke Patterns, and Learning Outcomes in Middle School Students' Online Problem-Solving Tasks: A Latent Profile Analysis
Relationships Among Impulsivity, Keystroke Patterns, and Learning Outcomes in Middle School Students' Online Problem-Solving Tasks: A Latent Profile Analysis Open
View article: Thalamocortical white matter connectivity and the entorhinal cortex as neural correlates of electroconvulsive therapy response in patients with schizophrenia spectrum disorder
Thalamocortical white matter connectivity and the entorhinal cortex as neural correlates of electroconvulsive therapy response in patients with schizophrenia spectrum disorder Open
These findings suggest that a reduction in increased thalamo-PC WM connectivity may be a biomarker for ECT response in SSD patients. Furthermore, the right entorhinal cortex may be a neuromodulation target for treatment-resistant SSD.
View article: The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Open
View article: Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status
Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status Open
Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive–compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on t…
View article: Stability of psychotic symptoms and safety in switching to aripiprazole once-monthly according to prior oral antipsychotic drugs
Stability of psychotic symptoms and safety in switching to aripiprazole once-monthly according to prior oral antipsychotic drugs Open
Long-acting injectable aripiprazole has substantiated safety and efficacy in treating schizophrenia. However, interindividual variability in clinical response to aripiprazole, possibly linked to its D2 partial agonism and D2 upregulation d…
View article: Large Language Models Are More Persuasive Than Incentivized Human Persuaders
Large Language Models Are More Persuasive Than Incentivized Human Persuaders Open
We directly compare the persuasion capabilities of a frontier large language model (LLM; Claude Sonnet 3.5) against incentivized human persuaders in an interactive, real-time conversational quiz setting. In this preregistered, large-scale …
View article: The neural basis of intuitive approximate number system in board game Go (Baduk) experts
The neural basis of intuitive approximate number system in board game Go (Baduk) experts Open
Studies have shown that newborns and nonhuman animals innately estimate quantities using the approximate number system (ANS), raising questions about whether the ANS is a precursor to advanced computational abilities or an independent cogn…
View article: A Novel Face Recognition Approach for Reducing Training Time and Strengthening Security
A Novel Face Recognition Approach for Reducing Training Time and Strengthening Security Open
View article: A Literature Review and Preliminary Study on Proteomic Research Associated With the Therapeutic Mechanism and Efficacy of Electroconvulsive Therapy in Schizophrenia Patients
A Literature Review and Preliminary Study on Proteomic Research Associated With the Therapeutic Mechanism and Efficacy of Electroconvulsive Therapy in Schizophrenia Patients Open
The mechanism of electroconvulsive therapy (ECT) in schizophrenia remains unclear, with limited research available. Previous studies have reported ECT-induced changes in protein markers, including neurotrophic factors, inflammatory markers…