Jun Jiang
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View article: The P2X7 receptor in depression: Novel insights and therapeutic implications
The P2X7 receptor in depression: Novel insights and therapeutic implications Open
Major depressive disorder (MDD) is a heterogeneous mental disorder involving multiple pathogenic mechanisms. Current first-line antidepressant medications suffer from slow onset of action, limited effectiveness, and high side effects, nece…
View article: Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism
Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism Open
Introduction Curcumin has been found to inhibit atherosclerosis. However, its poor stability and low activity severely limit its further application. To overcome the shortcomings of curcumin, our team successfully designed a novel curcumin…
View article: Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects
Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects Open
Currently, conventional antidepressants are often limited by poor efficacy and delayed onset, and there is an urgent need for the development of rapid acting antidepressant alternatives. The aim of this study was to develop novel antidepre…
View article: Sparse SGNN for Interpretable Learning of Stationary Solutions of Fokker-Planck-Kolmogorov Equations
Sparse SGNN for Interpretable Learning of Stationary Solutions of Fokker-Planck-Kolmogorov Equations Open
This paper introduces an interpretable machine learning framework that combines Separable Gaussian Neural Networks (SGNN) and sparse regression to solve stationary solutions of FPK equations. The structure of SGNN naturally satisfies the b…
View article: The "Yanpei Special-order Class" Model of Integrated Secondary and Higher Vocational Education: The Cradle of Innovative Skilled Talents in Wenzhou Packaging and Printing Industry
The "Yanpei Special-order Class" Model of Integrated Secondary and Higher Vocational Education: The Cradle of Innovative Skilled Talents in Wenzhou Packaging and Printing Industry Open
This paper focuses on the Wenzhou packaging and printing industry and deeply explores the cultivation of innovative skilled talents through the "Yanpei Special-order Class" model of integrated secondary and higher vocational education. Thr…
View article: A novel method for response probability density of nonlinear stochastic dynamic systems
A novel method for response probability density of nonlinear stochastic dynamic systems Open
This paper presents a novel method for analyzing high-dimensional nonlinear stochastic dynamic systems. In particular, we attempt to obtain the solution of the Fokker–Planck–Kolmogorov (FPK) equation governing the response probability dens…
View article: Sustainable and Rapid Water Purification at the Confined Hydrogel Interface
Sustainable and Rapid Water Purification at the Confined Hydrogel Interface Open
Emerging organic contaminants in water matrices have challenged ecosystems and human health safety. Persulfate‐based advanced oxidation processes (PS‐AOPs) have attracted much attention as they address potential water purification challeng…
View article: The Potential Mechanisms of Arrhythmia in Coronavirus disease-2019
The Potential Mechanisms of Arrhythmia in Coronavirus disease-2019 Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease-2019 (COVID-19) which can cause severe cardiovascular complications including myocardial injury, arrhythmias, acute coronary syndrome and others. Amo…
View article: Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells
Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells Open
Background The over-activation of adenosine A 2A receptors (A 2A R) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A 2A R blockade possesses neuroprotective effects on AD. Spatial na…
View article: On the optimal design of radial basis function neural networks for the analysis of nonlinear stochastic systems
On the optimal design of radial basis function neural networks for the analysis of nonlinear stochastic systems Open
In this paper, an iterative selection strategy of Gaussian neurons for radial basis function neural networks (RBFNN) is proposed when the RBFNN method is applied to obtain the steady-state solution of the Fokker–Planck–Kolmogorov (FPK) equ…
View article: Fuzzy optimal control of nonlinear systems by fuzzy generalized cell mapping method with Bellman’s principle
Fuzzy optimal control of nonlinear systems by fuzzy generalized cell mapping method with Bellman’s principle Open
A novel method is proposed in this paper to obtain global solutions of fuzzy optimal control with fixed state terminal conditions and control bounds. The global solution implies that the optimal control solutions are valid for all the init…
View article: Blue-Sky Catastrophic Bifurcations Behind Emergence and Disappearance of Quasiperiodic Rubbing Oscillations in a Piecewise Smooth Rotor–Stator System
Blue-Sky Catastrophic Bifurcations Behind Emergence and Disappearance of Quasiperiodic Rubbing Oscillations in a Piecewise Smooth Rotor–Stator System Open
In this paper, an approach combining the methods of multigrid Point Mapping under Cell Reference and Stagger-and-step is proposed, which can efficiently determine both attractors and unstable saddle-type invariant sets in higher-dimensiona…
View article: An image encryption scheme using a chaotic neural network and a network with multistable hyperchaos
An image encryption scheme using a chaotic neural network and a network with multistable hyperchaos Open
In this paper a new image encryption scheme is proposed, by which the pixel values are bit-level shuffled by the encryption sequences generated by a complex network, while the pixel positions of diffused images are scrambled by the chaotic…
View article: TriCTI: an actionable cyber threat intelligence discovery system via trigger-enhanced neural network
TriCTI: an actionable cyber threat intelligence discovery system via trigger-enhanced neural network Open
The cybersecurity report provides unstructured actionable cyber threat intelligence (CTI) with detailed threat attack procedures and indicators of compromise (IOCs), e.g., malware hash or URL (uniform resource locator) of command and contr…
View article: Random vibration analysis with radial basis function neural networks
Random vibration analysis with radial basis function neural networks Open
Random vibrations occur in many engineering systems including buildings subject to earthquake excitation, vehicles traveling on a rough road and off-shore platform in random waves. Analysis of random vibrations for linear systems has been …
View article: Research on sensorless control system of low speed and high power PMSM based on improved high frequency signal injection
Research on sensorless control system of low speed and high power PMSM based on improved high frequency signal injection Open
With more and more applications of high-power PMSM in low-speed applications, the accuracy of the control system has also become more demanding. It is difficult to detect the position and control the speed of the motor according to the cou…
View article: Synchronization precision analysis of a fractional-order hyperchaos with application to image encryption
Synchronization precision analysis of a fractional-order hyperchaos with application to image encryption Open
This paper proposes an effective image encryption algorithm based on the transformational prospective synchronization of a fractional-order hyperchaotic system. Compared with other chaos-based algorithms, fractional orders and synchronizat…
View article: Improved Fractional Subequation Method and Exact Solutions to Fractional Partial Differential Equations
Improved Fractional Subequation Method and Exact Solutions to Fractional Partial Differential Equations Open
In this paper, the improved fractional subequation method is applied to establish the exact solutions for some nonlinear fractional partial differential equations. Solutions to the generalized time fractional biological population model, t…
View article: Variational Problems with Partial Fractional Derivative: Optimal Conditions and Noether’s Theorem
Variational Problems with Partial Fractional Derivative: Optimal Conditions and Noether’s Theorem Open
In this paper, the necessary and sufficient conditions of optimality for variational problems with Caputo partial fractional derivative are established. Fractional Euler-Lagrange equations are obtained. The Legendre condition and Noether’s…
View article: Dynamic Response and Stability Analysis with Newton Harmonic Balance Method for Nonlinear Oscillating Dielectric Elastomer Balloons
Dynamic Response and Stability Analysis with Newton Harmonic Balance Method for Nonlinear Oscillating Dielectric Elastomer Balloons Open
Subject to various pressure and voltage values, the deformation of a hyperelastic dielectric elastomer membrane may attain different stable and unstable equilibria. In this paper, the neo-Hookean material model is adopted to describe the h…
View article: Exact Solutions to the Fractional Differential Equations with Mixed Partial Derivatives
Exact Solutions to the Fractional Differential Equations with Mixed Partial Derivatives Open
In this paper, the solvability of nonlinear fractional partial differential equations (FPDEs) with mixed partial derivatives is considered. The invariant subspace method is generalized and is then used to derive exact solutions to the nonl…
View article: Approximation of Stochastic Quasi-Periodic Responses of Limit Cycles in Non-Equilibrium Systems under Periodic Excitations and Weak Fluctuations
Approximation of Stochastic Quasi-Periodic Responses of Limit Cycles in Non-Equilibrium Systems under Periodic Excitations and Weak Fluctuations Open
A semi-analytical method is proposed to calculate stochastic quasi-periodic responses of limit cycles in non-equilibrium dynamical systems excited by periodic forces and weak random fluctuations, approximately. First, a kind of 1/N-strobos…
View article: Large-scale stabilization control of input-constrained quadrotor
Large-scale stabilization control of input-constrained quadrotor Open
The quadrotor has been the most popular aircraft in the last decade due to its excellent dynamics and continues to attract ever-increasing research interest. Delivering a quadrotor from a large fixed-wing aircraft is a promising applicatio…
View article: Crises in a non-autonomous fractional-order Duffing system
Crises in a non-autonomous fractional-order Duffing system Open
In this paper, the crises in a non-autonomous fractional-order Duffing system are investigated. Firstly, based on the short memory principle of fractional derivative, a global numerical method called an extended generalized cell mapping (E…