Jun Nakajima
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View article: Decreased fatty liver index with tirzepatide treatment in Japanese patients with type 2 diabetes: A <scp>SURPASS</scp> J‐mono post hoc analysis
Decreased fatty liver index with tirzepatide treatment in Japanese patients with type 2 diabetes: A <span>SURPASS</span> J‐mono post hoc analysis Open
View article: Chromatin organizer ASCL1 governs gene programs in thymic epithelial cells, defining immunological self
Chromatin organizer ASCL1 governs gene programs in thymic epithelial cells, defining immunological self Open
Immunological self-tolerance depends on the gene expression program of medullary thymic epithelial cells (mTECs), which ectopically express thousands of tissue-specific self-antigens (TSAs). Although the autoimmune regulator AIRE is essent…
View article: Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution Open
Current molecular quantitative trait locus catalogs are mostly at bulk resolution and centered on Europeans. Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, hos…
View article: Postoperative pneumothorax occurrence in patients with Marfan syndrome
Postoperative pneumothorax occurrence in patients with Marfan syndrome Open
Objectives Marfan syndrome is a congenital connective tissue disorder frequently complicated by pneumothorax. However, the long-term efficacy of surgical intervention in these cases remains underreported. This study aimed to assess the sur…
View article: Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors
Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors Open
Background Effector regulatory T cells expressing C-C chemokine receptor 4 (CCR4) suppress antitumor immune responses. We conducted a phase I clinical trial to evaluate the safety and efficacy of preoperative combination therapy with mogam…
View article: Real‐world clinical practice of current periprocedural anticoagulation management in catheter ablation of atrial fibrillation: Data from a large prospective ablation registry
Real‐world clinical practice of current periprocedural anticoagulation management in catheter ablation of atrial fibrillation: Data from a large prospective ablation registry Open
Background The guidelines recommend anticoagulation management with uninterrupted warfarin or direct thrombin inhibitors (DTIs) during the atrial fibrillation (AF) ablation periprocedural period. Objectives To clarify the Japanese real‐wor…
View article: Long‐term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study
Long‐term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study Open
Background This study was designed to evaluate the long‐term durability, oxygenation, and pressure loss of newly developed, methacryloyloxyethyl phosphorylcholine (MPC)‐polymer‐coated, nonporous silicone hollow fiber‐membrane lungs in vivo…
View article: AB034. Single-cell RNA-seq reveals altered gene expression and cellular composition in thymic epithelial cells of type B thymoma
AB034. Single-cell RNA-seq reveals altered gene expression and cellular composition in thymic epithelial cells of type B thymoma Open
BACKGROUND: Thymic epithelial cells (TECs) play a crucial role in thymoma pathogenesis and associated autoimmune conditions. This study aims to elucidate the alterations in gene expression and cellular composition of TECs within type B thy…
View article: Diagnosis of Respiratory Sarcopenia for Stratifying Postoperative Risk in Non–Small Cell Lung Cancer
Diagnosis of Respiratory Sarcopenia for Stratifying Postoperative Risk in Non–Small Cell Lung Cancer Open
Importance Physical biomarkers for stratifying patients with lung cancer into subtypes suggestive of outcomes are underexplored. Objective To investigate the clinical utility of respiratory sarcopenia for optimizing postoperative risk stra…
View article: Increased white blood cell count is associated with an increased demand for unfractionated heparin during veno-arterial extracorporeal oxygenation in lung transplantation
Increased white blood cell count is associated with an increased demand for unfractionated heparin during veno-arterial extracorporeal oxygenation in lung transplantation Open
Background : This retrospective observational study aimed to examine whether clinical inflammatory parameters were associated with the requirement dosage of unfractionated heparin (UFH) to maintain the range of ACT in veno-arterial extraco…
View article: Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts
Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts Open
Macrophages contribute to post-transplant lung rejection. Disulfiram (DSF), an anti-alcoholic drug, has an anti-inflammatory effect and regulates macrophage chemotactic activity. Here, we investigated DSF efficacy in suppressing acute reje…
View article: Comprehensive Risk Assessment in Patients With Pulmonary Arterial Hypertension Referred for Lung Transplantation
Comprehensive Risk Assessment in Patients With Pulmonary Arterial Hypertension Referred for Lung Transplantation Open
Patients classified as high intermediate or high risk by the MRA after treatment should be referred for LT.
View article: Effects of case volume on short- and long-term outcomes following cadaveric lung transplantation in Japan
Effects of case volume on short- and long-term outcomes following cadaveric lung transplantation in Japan Open
Case volume did not have effects on short- or long-term outcomes following LT in Japan, while there were large variations in long-term outcomes among the LV centers compared to those of the HV centers.
View article: Pulmonary wedge resection for lung cancer developing in a single transplanted lung: a case report
Pulmonary wedge resection for lung cancer developing in a single transplanted lung: a case report Open
View article: Editorial for Living-donor Lobar Lung Transplantation - Initiation and Development in Japan
Editorial for Living-donor Lobar Lung Transplantation - Initiation and Development in Japan Open
View article: A single-cell atlas of transcribed<i>cis</i>-regulatory elements in the human genome
A single-cell atlas of transcribed<i>cis</i>-regulatory elements in the human genome Open
Summary Transcribed cis-regulatory elements (tCREs), such as promoters and enhancers, are fundamental to modulate gene expression and define cell identity. The detailed mapping of tCREs at single-cell resolution is essential for understand…
View article: Comprehensive risk assessment in patients with pulmonary arterial hypertension referred for lung transplantation: a single-center experience
Comprehensive risk assessment in patients with pulmonary arterial hypertension referred for lung transplantation: a single-center experience Open
Background Current guidelines recommend risk stratification to optimize the timing to refer patients with pulmonary arterial hypertension (PAH) for lung transplantation (LT). However, the optimal timing for referral may vary by country. It…
View article: Adjunctive posterior wall isolation for the treatment of persistent and longstanding persistent atrial fibrillation (CORNERSTONE AF) trial: Design and rationale
Adjunctive posterior wall isolation for the treatment of persistent and longstanding persistent atrial fibrillation (CORNERSTONE AF) trial: Design and rationale Open
Background A left atrial posterior wall isolation (LAPWI) is one of the atrial fibrillation (AF) ablation strategies. Hypothesis We hypothesized that an additional empirical LAPWI would increase the freedom from recurrent atrial arrhythmia…
View article: Readmissions and costs in cadaveric and living-donor lobar lung transplantation: Analysis using a national database
Readmissions and costs in cadaveric and living-donor lobar lung transplantation: Analysis using a national database Open
View article: Laser isotope separation to study for the neutrino-less double beta decay of <sup>48</sup>Ca
Laser isotope separation to study for the neutrino-less double beta decay of <sup>48</sup>Ca Open
The laser isotope separation (LIS) system is being developed for the study of neutrino-less double beta decay of 48 Ca. A proof-of-principle experiment has been successfully conducted, and development of a mass production (∼1 mol/year) sys…
View article: Bilateral living-related lobar lung transplantation avoiding bronchial stenosis associated with scoliosis by modified anastomosis: a case report
Bilateral living-related lobar lung transplantation avoiding bronchial stenosis associated with scoliosis by modified anastomosis: a case report Open
Background Severe thoracic deformity caused by scoliosis often hampers lung transplantation (LTx) due to its underlying restrictive ventilatory dysfunction. Postoperative stenosis of the reconstructed bronchus due to spinal compression is …
View article: Corrigendum to “Evaluation of injury threshold from the number of rib fracture for predicting pulmonary injuries in blunt chest trauma” [Heliyon 9 (4), (April 2023) Article e15278]
Corrigendum to “Evaluation of injury threshold from the number of rib fracture for predicting pulmonary injuries in blunt chest trauma” [Heliyon 9 (4), (April 2023) Article e15278] Open
View article: Modified Ravitch procedure for pectus excavatum in Marfan syndrome with annuloaortic ectasia
Modified Ravitch procedure for pectus excavatum in Marfan syndrome with annuloaortic ectasia Open
OBJECTIVES This case series aimed to determine the feasibility of simultaneous modified Ravitch and David procedure for Marfan syndrome patients with pectus excavatum and annuloaortic ectasia. METHODS Between March 2014 and December 2019, …
View article: A Case of Fatal Caffeine Overdose
A Case of Fatal Caffeine Overdose Open
症例は20歳代，女性．自殺目的にカフェイン（無水カフェインにして約15 g）を自室内で大量に内服し倒れていたところを家族に発見され，救急要請となった．病院到着時に心室細動となったため体外循環を含む心肺蘇生を開始し集中治療室に入室した．血液検査で著明なアシドーシスと低カリウム血症が判明し，持続的血液濾過透析とカリウム持続投与による電解質補正も実施したところ，来院後356分に洞調律へ復帰した．第2病日に撮影した頭部CTでは皮髄境界の不明瞭化があり，脳波検査では脳波の平坦化が認め…
View article: Retrospective comparison between definitive stereotactic body radiotherapy and radical surgery for 538 patients with early-stage non-small cell lung cancer in a single institution
Retrospective comparison between definitive stereotactic body radiotherapy and radical surgery for 538 patients with early-stage non-small cell lung cancer in a single institution Open
Introduction: Survival information for stereotactic body radiotherapy (SBRT) and surgery for stage I non–small cell lung cancer (NSCLC) was examined. Methods: Stage I NSCLC patients who underwent surgery or SBRT between 2012 and 2016 were …
View article: Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity Open
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononu…
View article: Minimally Invasive Thymectomy Could Be Attempted for Locally Advanced Thymic Malignancies: A Real-World Study With Propensity Score-Matched Analysis
Minimally Invasive Thymectomy Could Be Attempted for Locally Advanced Thymic Malignancies: A Real-World Study With Propensity Score-Matched Analysis Open
View article: Prognostic factors for lung transplant recipients focusing on age and gender: the Japanese lung transplantation report 2022
Prognostic factors for lung transplant recipients focusing on age and gender: the Japanese lung transplantation report 2022 Open
View article: Fissureless technique of robotic left lingular segmentectomy for primary lung cancer with incomplete fissure: a case report
Fissureless technique of robotic left lingular segmentectomy for primary lung cancer with incomplete fissure: a case report Open
View article: Evaluation of injury threshold from the number of rib fracture for predicting pulmonary injuries in blunt chest trauma
Evaluation of injury threshold from the number of rib fracture for predicting pulmonary injuries in blunt chest trauma Open