Explanipedia

Relationship Between Thickness and Stability in Impurity-Doped ZnO Thin-Film Transparent Electrodes Open

Tadatsugu Minami, Jun’ichi Oda, Youhei Hara, Toshihiro Miyata, Haruki Fukada · 2008

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Crystal structure of γ-glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis Open

Takao Hibi, H. Nii, Toru Nakatsu, Akira Kimura, Hiroaki Kato , et al. · 2004

γ-Glutamylcysteine synthetase (γGCS), a rate-limiting enzyme in glutathione biosynthesis, plays a central role in glutathione homeostasis and is a target for development of potential therapeutic agents against parasites and cancer. We have…

Recognition of a Cysteine Substrate byE. coliγ-Glutamylcysteine Synthetase Probed by Sulfoximine-based Transition-state Analogue Inhibitors Open

Jun Hiratake, Takayuki Irie, Nobuya Tokutake, Jun’ichi Oda · 2002

A series of sulfoximine-based transition-state analogue inhibitors with a varying alkyl side chain was synthesized to probe the recognition of a Cys substrate by E. coli gamma-glutamylcysteine synthetase (gamma-GCS). The sulfoximines with …

Potent Transition-State Analogue Inhibitor of Esherichia coli Asparagine Synthetase A (MOLECULAR BIOFUNCTION-Functional Molecular Conversion) Open

Jun Hiratake, Mitsuteru Koizumi, Toru Nakatsu, Hiroaki Kato, Jun’ichi Oda · 2000

A potent and slow-binding inhibitor of E. coli asparagine synthetase A (AS-A) was synthesized, and its inhibition behavior was characterized. The enzyme complexed with the inhibitor was analyzed by X-ray diffraction analysis to identify se…

Site-directed Mutagenesis of Putative Substrate-binding Residues Reveals a Mechanism Controlling the Different Stereospecificities of Two Tropinone Reductases Open

Keiji Nakajima, Hiroaki Kato, Jun’ichi Oda, Yasuyuki Yamada, Takashi Hashimoto · 1999

Two tropinone reductases (TRs) constitute a key branch point in the biosynthetic pathway of tropane alkaloids, which are mainly produced in several solanaceous plants. The two TRs share 64% identical amino acid residues and reduce the 3-ca…

Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold. (MOLECULAR BIOFUNCTION-Functional Molecular Conversion) Open

Keiji Nakajima, Atsuko Yamashita, Hiroyuki Akama, Toru Nakatsu, Hiroaki Kato , et al. · 1999

A pair of tropinone reductases (TRs) share 64% identical amino acid residues, and belong to the shortchain dehydrogenase/reductase family. In the synthesis of tropane alkaloids in several medicinal plants, the TRs reduce a carbonyl group o…

Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold Open

Keiji Nakajima, Atsuko Yamashita, Hiroyuki Akama, Toru Nakatsu, Hiroaki Kato , et al. · 1998

A pair of tropinone reductases (TRs) share 64% of the same amino acid residues and belong to the short-chain dehydrogenase/reductase family. In the synthesis of tropane alkaloids in several medicinal plants, the TRs reduce a carbonyl group…

Crystal Structure of Asparagine Synthetase Reveals a Close Evolutionary Relationship to Class II Aminoacyl-tRNA Synthetase (MOLECULAR BIOFUNCTION-Functional Molecular Conversion) Open

Toru Nakatsu, Hiroaki Kato, Jun’ichi Oda · 1998

The crystal structure of E. coli asparagine synthetase has been determined by X-ray diffraction analysis at 2.5 A resolution. The overall structure of the enzyme is remarkably similar to that of the catalytic domain of yeast aspartyl-tRNA …

Molecular Properties and Activity of Amino-Terminal Truncated Forms of Lipase Activator Protein Open

Hiroyuki Shibata, Hiroaki Kato, Jun’ichi Oda · 1998

Two mutant forms, which had truncated N-terminals, of lipase activator protein (LipB) from Pseudomonas aeruginosa TE3285 were prepared, and their molecular properties and activity were compared with those of the full-length form. A truncat…

Cysteine Protease Inhibitors Produced by the Industrial Koji Mold,Aspergillus oryzaeO-1018 Open

Takao Yamada, Jun Hiratake, Mototsune AIKAWA, Tetsuyoshi Suizu, Yoshiyuki Saito , et al. · 1998

Aspergillus oryzae O-1018 (FERM P-15834) separated from industrial koji for brewing sake was found to produce five papain-inhibitory compounds in the culture supernatant. The five isolated inhibitors were named CPI-1 to CPI-5, and their st…

Mechanism-Based Inactivation of E.coli g-Glutamylcysteine Synthetase by Phosphinic Acid- and Sulfoximine-Based Transition-State Analogues (MOLECULAR BIOFUNCTION-Functional Molecular Conversion) Open

Makoto Katoh, Jun Hiratake, Hiroaki Kato, Jun’ichi Oda · 1997

On the basis of the proposed reaction mechanisms of g-glutamylcysteine synthetase, tetrahedral phosphinic acid- and sulfoximine-based compounds 1 and 2 were synthesized and evaluated as inhibitors of E. coli g- glutamylcysteine synthetase.…

Aminophosphonic and Aminoboronic Acids as Key Elements of a Transition State Analogue Inhibitor of Enzymes Open

Jun Hiratake, Jun’ichi Oda · 1997

Amino acid analogues are of considerable interest as inhibitors of enzymes involved in amino acid and peptide metabolism. In particular, α-aminoalkylphosphonic acids and α-aminoalkylboronic acids, in which the carboxyl group of amino acids…

Challenge of Organic Synthesis-toward the 21st Century. Organic Synthesis and Catalytic Antibodies. Open

Jun Hiratake, Jun’ichi Oda · 1997

One of the major goals of catalytic antibodies is to provide tailor-made catalysts for use in practical organic synthesis. Reflecting the increasing demand for enantio- and regioselective catalysts in organic synthesis, the scope of antibo…

Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins Open

K. Matsuda, Kenji Mizuguchi, Takaaki Nishioka, Hiroaki Kato, Nobuhiro Gō , et al. · 1996

The crystal structure of Escherichia coli B glutathione synthetase (GSHase) has been determined at the optimal catalytic condition pH 7.5. The most significant structural difference from the structure at pH 6.0 is the movement of the centr…

Studies on Functional Analysis and Application of Biocatalysts Open

Jun’ichi Oda · 1996

Protein Crystallography and Structural Biology. Cooperation with Relarted Sciences and Future Plans. Organic Chemistry and Protein Crystallography Probing Enzyme Mechanisms with Transition State Analogs. Open

Hiroaki Kato, Jun’ichi Oda · 1996

The purpose of this review is to describe what is deduced about the source of the catalytic power for enzymes, using as guides the crystal structures of the enzymes complexed with transition-state analogs. We start with an overview of tran…

Mechanism-Based Inactivation of Glutathione Synthetase by Phosphinic Acid Transition-State Analogue (MOLECULAR BIOFUNCTION - Functional Molecular Conversion) Open

Jun Hiratake, Hiroaki Kato, Jun’ichi Oda · 1995

Identification of Biochemical Function of Lipase Activator Gene (lipB) from Pseudomonas aeruginosa TE 3285 Open

Takaaki Nishioka, Jun’ichi Oda · 1995

Lipase gene from Pseudomonas species is followed with an accessory gene called lipase activator gene, which is necessary for the production and excretion of mature lipase. The biochemical function of the activator gene has remained undeter…

Visualization of Mobile Regions in Proteins by X-Ray Crystallography. Open

Hiroaki Kato, Jun’ichi Oda · 1994

Construction, Expression, and Characterization of Glutathione Synthetase Chimeras : Substitution of a Loop with a Homologous Peptide Region of Dihydrofolate Reductase (Commemoration Issue Dedicated to Professor Mituru Takanami On the Occasion of His Retirement) Open

Takuji Tanaka, Tetsuya Sakai, Mikiko Chihara-Siomi, Kazuya Takeshima, Hiroaki Kato , et al. · 1993

Lipase from Pseudomonas aeruginosa Open

Noriko Oshima-Hirayama, Kenichi Yoshikawa, Takaaki Nishioka, Jun’ichi Oda · 1993

The lipase gene from Pseudomonas aeruginosa TE3285 is followed by another gene, lipB . The lipase gene was expressed in Escherichia coli BL21(DE3)pLysS using the T7 RNA polymerase expression system. The mature lipase was accumulated as inc…

Kinetic Resolution of Racemic α-Aminonitriles via Stereoselective N-Acetylation Catalyzed by Lipase in Organic Solvent (Commemoration Issue Dedicated to Professor Shigeo Tanimoto On the Occation of His Retirement) Open

Katsumi Nakai, Jun Hiratake, Jun’ichi Oda · 1992

Recent Progress in the Structure of CN-bond Ligases. Open

Hiroaki Kato, Jun’ichi Oda · 1991

Lipase-catalyzed Stereoselective Hydrolysis of Thiolacetate Open

Naomichi Baba, M. MIMURA, Jun’ichi Oda, Junkichi Iwasa · 1990

Asymmetric synthesis of optically active 3-substituted .DELTA.-valerolactones using lipase in organic solvents. Open

Yukio Yamamoto, Mineyuki Iwasa, Seiji Sawada, Jun’ichi Oda · 1990

In organic solvents, lipase Amano P catalyzed the asymmetric ring opening of glutaric anhydrides bearing -CH2Cl, -CH2F and -OCH3 groups at position 3 with methanol and 1-butanol to afford the corresponding mono esters in 70-86% e.e. Optica…

Lipase-catalyzed kinetic resolution of racemic methyl 13-hydroperoxy-9Z, 11E-octadecadienoate in an organic solvent. Open

Naomichi Baba, Kazuya Tateno, Junkichi Iwasa, Jun’ichi Oda · 1990

Hydroperoxidation of 9-Hexylfluorene and Weitz-Scheffer, Epoxidation of Cyclohexenones under Phase Transfer Condition (Commemoration Issue Dedicated to Professor Shinzaburo OKA On the Occasion of His Retirement) Open

Naomichi Baba, Jun’ichi Oda, Seiichi Kawahara, Masashi Hamada · 1989

Kinetic Resolution of Racemic Benzaldehyde Cyanohydrin via Stereoselective Acetylation Catalyzed by Lipase in Orga n i c Solvent (Commemoration Issue Dedicated to Professor Shinzaburo OKA On the Occasion of His Retirement) Open

Minoru Inagaki, Jun Hiratake, Takaaki Nishioka, Jun’ichi Oda · 1989

Overexpression of Glutathione Synthetase inEscherichia coli Open

Hiroaki Kato, Mariko Kobayashi, Kousaku Murata, Takaaki Nishioka, Jun’ichi Oda · 1989

Lipase-catalyzed stereoselective acylation of [1,1'-binaphthyl]-2,2'-diol and deacylation of its esters in an organic solvent. Open

Minoru Inagaki, Jun Hiratake, Takaaki Nishioka, Jun’ichi Oda · 1989

A kinetic resolution of [1, 1-binaphthyl]-2, 2'-diol (binaphthol) and its esters was first accomplished by lipase-catalyzed transesterification in an organic solvent. Acylation of binaphthol with enol esters in diisopropyl ether-acetone (9…

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