Junping Wang
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View article: Ferulic Acid Promotes Hematopoietic Stem Cell Maintenance in Homeostasis and Injury Through Diminishing Ferroptosis Susceptibility
Ferulic Acid Promotes Hematopoietic Stem Cell Maintenance in Homeostasis and Injury Through Diminishing Ferroptosis Susceptibility Open
Redox balance is essential for maintenance of the hematopoietic stem cell (HSC) pool, which ensures the lifelong hematopoiesis. However, oxidative attack induced by various physiopathological stresses always compromises HSC maintenance, wh…
View article: Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISO
Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISO Open
s Alternative polyadenylation (APA) is a critical posttranscriptional mechanism that generates transcriptomic diversity through the production of mRNA isoforms with distinct 3’ UTRs or coding sequences. Current APA analysis based on single…
View article: Dynamic expression and regulation of corticotropin-releasing hormone and urotensin I during metamorphosis of olive flounder Paralichthys olivaceus
Dynamic expression and regulation of corticotropin-releasing hormone and urotensin I during metamorphosis of olive flounder Paralichthys olivaceus Open
View article: Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding
Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding Open
Ionizing radiation-induced intestinal injury (IRIII) is a catastrophic disease lack of sufficient medical countermeasures currently. Regulation of the gut microbiota through dietary adjustments is a potential strategy to mitigate IRIII. Ti…
View article: The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing Open
Background Effective control of inflammation is crucial for the healing of cutaneous wounds, but the molecular mechanisms governing inflammation resolution during wound closure are still not yet clear. Here, we describe a homeostatic mecha…
View article: New insights into the generation and function of megakaryocytes in health and disease
New insights into the generation and function of megakaryocytes in health and disease Open
Megakaryocytes (MKs) are canonically viewed as specialized hematopoietic cells merely producing platelets and generated through a series of hematopoietic stem and progenitor cells in the bone marrow (BM). Despite essential physiological fu…
View article: Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spar…
View article: Author response: Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Author response: Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning Open
View article: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spa…
View article: Author response: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Author response: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
View article: Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions Open
View article: Network pharmacology and <i>in vivo</i> study: Unraveling the therapeutic mechanisms of <i>Panax ginseng</i> in potentially treating ulcerative colitis
Network pharmacology and <i>in vivo</i> study: Unraveling the therapeutic mechanisms of <i>Panax ginseng</i> in potentially treating ulcerative colitis Open
BACKGROUND Ulcerative colitis (UC), a chronic and challenging condition, necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications. Traditional Chine…
View article: Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?
Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? Open
Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers w…
View article: Synthesis, Characterization and Antifungal Activities of Amide and Acylthiourea of Substituted 2-Amino-1,3-Benzothiazole
Synthesis, Characterization and Antifungal Activities of Amide and Acylthiourea of Substituted 2-Amino-1,3-Benzothiazole Open
Objective: To search new antifungal compounds for effectively controling vital plant diseases, we designed and synthesized series of N-acyl and acylthiourea of substituted 2-amino-1,3-benzothiazole. Methods: The in vitro antifungal activit…
View article: Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis
Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis Open
View article: Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway
Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway Open
View article: Daytime-restricted feeding reshapes the gut microbiota to achieve intestinal radioprotection through creatine-mediated ferroptosis inhibition
Daytime-restricted feeding reshapes the gut microbiota to achieve intestinal radioprotection through creatine-mediated ferroptosis inhibition Open
Ionizing radiation-induced intestinal injury (IRIII), a catastrophic disease that occurs after tumor radiotherapy or accidental nuclear radiation, is lack of sufficient medical countermeasures currently. The gut microbial composition affec…
View article: Prolonged consumption of dietary advanced lipoxidation end products contributes to renal impairment in mice through dysregulated intestinal homeostasis
Prolonged consumption of dietary advanced lipoxidation end products contributes to renal impairment in mice through dysregulated intestinal homeostasis Open
Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products (ALEs), which potentially engenders the threat on systemic health or progression of diseases, esp…
View article: Mutual Information Guided Optimal Transport for Unsupervised Visible-Infrared Person Re-identification
Mutual Information Guided Optimal Transport for Unsupervised Visible-Infrared Person Re-identification Open
Unsupervised visible infrared person re-identification (USVI-ReID) is a challenging retrieval task that aims to retrieve cross-modality pedestrian images without using any label information. In this task, the large cross-modality variance …
View article: Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies
Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies Open
The UK Biobank (UKB) has the largest adult brain imaging dataset, which encompasses over 40,000 participants. A significant number of Mendelian randomization (MR) studies based on UKB neuroimaging data have been published to validate poten…
View article: scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data
scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data Open
The rapid development of single-cell sequencing offers an unparalleled opportunity to delineate the heterogeneity of individual cells. However, current methods struggle to pinpoint the states of cell fate decisions. In this study, we intro…
View article: Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening
Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening Open
Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our research identifies the transcription factor Nynrin as a crucial regulator of HSC maintenance by modulating mitochondrial function. Nynrin is highly expresse…
View article: Epigenetic regulation of megakaryopoiesis and platelet formation
Epigenetic regulation of megakaryopoiesis and platelet formation Open
Platelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases. During megakaryocyte differentiation, the mo…
View article: Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spar…
View article: Reviewer #2 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Reviewer #2 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spa…
View article: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spa…
View article: Reviewer #1 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Reviewer #1 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spa…
View article: Reviewer #3 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Reviewer #3 (Public Review): Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their spa…
View article: Author response: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Author response: Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning Open
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target bio-membranes and restrict a wide range of pathogens.It is a daunting challenge to discover novel AMPs due to their spar…
View article: Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury Open
Background Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is profoundly disrupted after myelosuppressive injury, while i…