Wenjun Li
YOU?
Author Swipe
View article: Identifying Key Predictors of Smoking Cessation Success: Text-Based Feature Selection Using a Large Language Model
Identifying Key Predictors of Smoking Cessation Success: Text-Based Feature Selection Using a Large Language Model Open
Introduction The most effective way to reduce mortality and morbidity among current smokers is to quit smoking. Although about half of smokers attempted to quit, only one-tenth succeeded in 2022. Understanding key predictors of smoking ces…
View article: RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability
RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability Open
RNA-binding proteins (RBPs) critically regulate post-transcriptional gene expression, yet their roles in chemotherapy resistance remain underexplored. Here, through a targeted siRNA screen of 40 RBM family members, we identified RNA-bindin…
View article: Genome‐based polyphasic taxonomy of desert‐derived <i>Kineococcus</i> reveals nine novel species with plant growth‐promoting traits
Genome‐based polyphasic taxonomy of desert‐derived <i>Kineococcus</i> reveals nine novel species with plant growth‐promoting traits Open
The genus Kineococcus is primarily found in extreme environments and plant‐associated habitats, suggesting its potential for stress tolerance and plant growth promotion. However, the diversity and functional potential of this genus remain …
View article: Enlarged perivascular spaces in the basal ganglia mediate the negative impact of HbA1c levels on mild cognitive impairment
Enlarged perivascular spaces in the basal ganglia mediate the negative impact of HbA1c levels on mild cognitive impairment Open
Background This study aimed to investigate the mediating effect of enlarged perivascular space (EPVS) in basal ganglia (BG) on the relationship between glycated hemoglobin (HbA1c) levels and mild cognitive impairment (MCI) in patients with…
View article: Epidemiological Characteristics and Genetic Diversity of Chicken Infectious Anemia Virus (CIAV) in Guangdong Province, China
Epidemiological Characteristics and Genetic Diversity of Chicken Infectious Anemia Virus (CIAV) in Guangdong Province, China Open
Chicken infectious anemia virus (CIAV) causes immunosuppression in poultry, leading to substantial global economic losses through both vertical and horizontal transmission. Since 2014, frequent outbreaks have been reported in southern Chin…
View article: The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults
The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults Open
Blood pressure variability (BPV) is linked to cardiovascular disease (CVD) and systemic inflammation in adults, but its relevance in young, healthy populations remains unclear. This study examined the association between short-term BPV and…
View article: Sequential microwave ablation combined with radioactive iodine‑125 seed implantation successfully cured multiple metastases of gallbladder cancer: A case report
Sequential microwave ablation combined with radioactive iodine‑125 seed implantation successfully cured multiple metastases of gallbladder cancer: A case report Open
Advanced tumors are associated with treatment dilemmas. High-risk diffuse metastasis results in increased difficulty in treatment. Furthermore, the deterioration of the patient's physical condition gives rise to an inability to tolerate hi…
View article: Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines Open
Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, and Bacillus Calmette-Guérin (BCG) remains the only clinically approved vaccine. An enduring challenge in TB vaccine development is systematic antigen selec…
View article: Therapeutic <i>Salmonella</i> induces long-term protective trained immunity in NK cells against cancer metastasis
Therapeutic <i>Salmonella</i> induces long-term protective trained immunity in NK cells against cancer metastasis Open
Trained immunity, a form of innate immune memory initially recognized in pathogen defense, has recently been reported to aid in combating cancer. Although trained immunity has been well-characterized in myeloid lineage cells, its presence …
View article: Role of pyroptosis in pregnancy-related diseases
Role of pyroptosis in pregnancy-related diseases Open
Pyroptosis, a form of programmed cell death characterized by inflammasome-mediated cellular swelling and membrane perforation. This pathway is involved in diverse pathophysiological processes, including inflammatory diseases and tumors. No…
View article: Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance
Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance Open
We previously showed that infiltrating cytotoxic immune cells are reprogrammed to regulatory-like/exhausted cells within accepted kidney allografts through a ‘defensive tolerance’ mechanism. We observed a regulatory B cell (Breg) signature…
View article: How perceived organizational support affects preschool teachers' engagement: Examining mediating effect of psychological empowerment
How perceived organizational support affects preschool teachers' engagement: Examining mediating effect of psychological empowerment Open
Preschool teachers' work engagement is a pivotal factor influencing children's developmental outcomes, classroom climate, and overall educational quality. Grounded in Self-Determination Theory (SDT) and the Job Demands-Resources (JD-R) mod…
View article: Unveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy
Unveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy Open
Background In the absence of a human leukocyte antigen (HLA)-matched donor, intensive immunosuppressive therapy (IST) combined with unrelated cord blood (IIST-UCB) a salvage treatment option for patients with severe aplastic anemia (SAA) w…
View article: HedraRAG: Coordinating LLM Generation and Database Retrieval in Heterogeneous RAG Serving
HedraRAG: Coordinating LLM Generation and Database Retrieval in Heterogeneous RAG Serving Open
This paper addresses emerging system-level challenges in heterogeneous retrieval-augmented generation (RAG) serving, where complex multi-stage workflows and diverse request patterns complicate efficient execution. We present HedraRAG, a ru…
View article: Evaluating for pentosan polysulfate maculopathy at a single academic institution
Evaluating for pentosan polysulfate maculopathy at a single academic institution Open
Purpose: To report the practices and outcomes of ophthalmic evaluations for pentosan polysulfate sodium (PPS) maculopathy at a single institution. Methods: This study was conducted on patients of Massachusetts Eye and Ear who had documente…
View article: CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration
CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration Open
Background: Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease mainly affecting the colon. The exact etiology of UC remains elusive. CD131 is a receptor subunit mediating the effects of hematopoietic growth factors gr…
View article: Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer
Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer Open
Background Pancreatic cancer (PC) is a highly malignant type of cancer characterized by poor prognosis and high mortality rate. The role of gap junction protein beta 4 (GJB4) in PC has been scarcely reported. Therefore, the aim of this stu…
View article: EUS-Guided Drainage for Pelvic Abscesses: A Chinese Single-Center Two-year Follow-up Study Highlighting Clinical Outcomes
EUS-Guided Drainage for Pelvic Abscesses: A Chinese Single-Center Two-year Follow-up Study Highlighting Clinical Outcomes Open
Background and Aim of Study Endoscopic ultrasound (EUS)- guided drainage has emerged as a novel technique for managing pelvic abscesses. This single-center retrospective study aims to assess the safety and efficacy of EUS-guided drainage i…
View article: Multimodal imaging analysis and structure-function correlation in patients exposed to pentosan polysulfate sodium
Multimodal imaging analysis and structure-function correlation in patients exposed to pentosan polysulfate sodium Open
Purpose: To study the anatomic and functional retinal changes in patients exposed to pentosan polysulfate (PPS) using multimodal imaging and mesopic microperimetry. Design: A cross-sectional consecutive case series. Methods: Patients expos…
View article: Individual Mode Characterization of 3D Solitons in a Spatiotemporal Mode‐Locked Fiber Laser
Individual Mode Characterization of 3D Solitons in a Spatiotemporal Mode‐Locked Fiber Laser Open
3D solitons in spatiotemporal mode‐locked (STML) fiber lasers have garnered significant attention due to their distinctive mode characteristics. However, the detailed characterization of individual modes remains challenging, limited by cur…
View article: Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction
Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction Open
Background Diabetes is a prevalent public health issue worldwide, and the cognitive dysfunction and subsequent dementia caused by it seriously affect the quality of life of patients. Methods Recent studies were reviewed to provide a compre…
View article: Maintenance of graft tissue–resident Foxp3+ cells is necessary for lung transplant tolerance in mice
Maintenance of graft tissue–resident Foxp3+ cells is necessary for lung transplant tolerance in mice Open
Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3+ T cell-enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3+ cells su…