Jun Seita
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View article: Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in Drosophila
Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in Drosophila Open
Dietary restriction (DR), whether applied during adulthood or juvenile stages, extends lifespan across diverse species. However, the mechanisms by which early-life dietary interventions influence adult physiology and longevity remain poorl…
View article: Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in <i>Drosophila</i>
Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in <i>Drosophila</i> Open
Dietary restriction (DR), whether applied during adulthood or juvenile stages, extends lifespan across diverse species. However, the mechanisms by which early-life dietary interventions influence adult physiology and longevity remain poorl…
View article: Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study
Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study Open
Background Dry eye disease (DED) is a common ocular condition with diverse and heterogeneous symptoms. Current treatment standards of DED include the post facto management of associated symptoms through topical eye drops. However, there is…
View article: Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics
Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics Open
The neural mechanisms underlying the sequential transitions of male sexual behaviors, including mounting, intromission, and ejaculation, remain largely unexplored. Here, we report that acetylcholine (ACh)-dopamine (DA) dynamics in the vent…
View article: Efficient HLA imputation from sequential SNPs data by transformer
Efficient HLA imputation from sequential SNPs data by transformer Open
Human leukocyte antigen (HLA) genes are associated with a variety of diseases, yet the direct typing of HLA alleles is both time-consuming and costly. Consequently, various imputation methods leveraging sequential single nucleotide polymor…
View article: Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry Open
Mapping protein interaction complexes in their natural state in vivo is arguably the Holy Grail of protein network analysis. Detection of protein interaction stoichiometry has been an important technical challenge, as few studies have focu…
View article: Mapping adipocyte interactome networks by Halotag-enrichment-mass spectrometry
Mapping adipocyte interactome networks by Halotag-enrichment-mass spectrometry Open
Mapping protein interaction complexes in their natural state in vivo represents the holy grail of protein network analysis. Detection of protein interaction stoichiometry has been an important technical challenge, as few studies have focus…
View article: Sequential Transitions of Male Sexual Behaviors Driven by Dual Acetylcholine-Dopamine Dynamics
Sequential Transitions of Male Sexual Behaviors Driven by Dual Acetylcholine-Dopamine Dynamics Open
Summary The neural mechanisms regulating sequential transitions of male sexual behaviors, such as mounting, intromission, and ejaculation, in the brain remain unclear. Here, we report that dopamine (DA) and acetylcholine (ACh) dynamics in …
View article: Best practices for multimodal clinical data management and integration: An atopic dermatitis research case
Best practices for multimodal clinical data management and integration: An atopic dermatitis research case Open
The MeDIA system solves the problem of multimodal clinical data integration, from complex text data such as medical records to big data such as omics data from a large number of patients. The system and the proposed best practices can be a…
View article: Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis Open
Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the c…
View article: Liquid-liquid extraction of lipidated peptides for direct identification of lipidation sites
Liquid-liquid extraction of lipidated peptides for direct identification of lipidation sites Open
Proteins can be modified by lipids in various ways, for example by myristoylation, palmitoylation, farnesylation, and geranylgeranylation—these processes are collectively referred to as lipidation. Current chemical proteomics using alkyne …
View article: A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue
A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue Open
Background: Peripheral vascular disease remains a leading cause of vascular morbidity and mortality worldwide despite advances in medical and surgical therapy. Besides traditional approaches, which can only restore blood flow to native art…
View article: HSC-independent definitive hematopoiesis persists into adult life
HSC-independent definitive hematopoiesis persists into adult life Open
It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate …
View article: Efficient HLA imputation from sequential SNPs data by Transformer
Efficient HLA imputation from sequential SNPs data by Transformer Open
Human leukocyte antigen (HLA) genes are associated with a variety of diseases, however direct typing of HLA is time and cost consuming. Thus various imputation methods using sequential SNPs data have been proposed based on statistical or d…
View article: Multifaceted analysis of cross-tissue, cross-sectional and longitudinal transcriptomes reveals phenotype–endotype associations in atopic dermatitis.
Multifaceted analysis of cross-tissue, cross-sectional and longitudinal transcriptomes reveals phenotype–endotype associations in atopic dermatitis. Open
Atopic dermatitis (AD) is a skin disease heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the context o…
View article: HSC-independent definitive hematopoietic cells persist into adult life
HSC-independent definitive hematopoietic cells persist into adult life Open
Summary The stem cell theory that all blood cells are derived from hematopoietic stem cell (HSC) is a central dogma in hematology. However, various types of blood cells are already produced from hemogenic endothelial cells (HECs) before th…
View article: Geriatric fragility fractures are associated with a human skeletal stem cell defect
Geriatric fragility fractures are associated with a human skeletal stem cell defect Open
Fragility fractures have a limited capacity to regenerate, and impaired fracture healing is a leading cause of morbidity in the elderly. The recent identification of a highly purified bona fide human skeletal stem cell (hSSC) and its commi…
View article: Demographic Information Initialized Stacked Gated Recurrent Unit for an Early Prediction of Sepsis
Demographic Information Initialized Stacked Gated Recurrent Unit for an Early Prediction of Sepsis Open
Sepsis is a life-threatening condition that occurs when the body's response to infection causes tissue damage, organ failure, or death.Sepsis is a major public health issue responsible for significant morbidity, mortality, and healthcare e…
View article: Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation
Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation Open
Key Points Upon injury, the mesothelium recruits neutrophils to the peritoneal space, which contributes to adhesion formation. Neutrophil recruitment and macrophage-depletion kinetics in adhesions differ from the normal innate response.
View article: A molecular cell atlas of the human lung from single cell RNA sequencing
A molecular cell atlas of the human lung from single cell RNA sequencing Open
Although single cell RNA sequencing studies have begun providing compendia of cell expression profiles, it has proven more difficult to systematically identify and localize all molecular cell types in individual organs to create a full mol…