Shujun Zhang
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Lycorine suppresses hepatocellular carcinoma via the reprogramming of myeloid and epithelial cells Open
Lycorine remodels the HCC TME through coordinated actions on malignant epithelial cells and immune populations, notably neutrophil and macrophage subpopulations. These findings support the potential development of lycorine-based combinatio…
View article: Ultra-high precision refractometric sensing via metasurface-enabled visualized vector beam characteristics
Ultra-high precision refractometric sensing via metasurface-enabled visualized vector beam characteristics Open
Biosensors are indispensable tools for personalized, public, and global healthcare applications. State-of-the-art nanostructure empowered biosensors are able to achieve label-free detection of biomarkers by means of wavelength shifts, or i…
View article: Flexoelectricity-driven giant polarization in (Bi, Na)TiO3-based ferroelectric thin films
Flexoelectricity-driven giant polarization in (Bi, Na)TiO3-based ferroelectric thin films Open
This study demonstrates the use of oxygen vacancy-induced planar defects to significantly enhance electrical polarization through a local flexoelectric effect. By introducing an appropriate level of aliovalent dopants, numerous local plana…
View article: Research advances in m6A methylation and sepsis
Research advances in m6A methylation and sepsis Open
Sepsis is an infection-induced syndrome driven primarily by dysregulated host inflammatory responses. This process induces complex physiological changes that provoke systemic inflammation and multi-organ dysfunction, severely threatening s…
View article: Epidemiological characteristics of human psittacosis in Guangdong Province, China, 2019–2024
Epidemiological characteristics of human psittacosis in Guangdong Province, China, 2019–2024 Open
Background Psittacosis is a non-statutory infectious disease and receives relatively low attention in China. Since 2019, the incidence of psittacosis in Guangdong Province has been continuously increasing. Therefore, it is necessary to und…
View article: Recent research advances in RNA m5C methylation modification in liver diseases
Recent research advances in RNA m5C methylation modification in liver diseases Open
RNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C). This crucial epigenetic modification significantly im…
View article: Enhanced electrocaloric effect in ferroelectric ceramics via defect dipole engineering
Enhanced electrocaloric effect in ferroelectric ceramics via defect dipole engineering Open
The increasing demand for higher operating speeds and greater integration densities in electronic devices has made heat dissipation one of the most critical challenges for next-generation technologies. This challenge has driven extensive e…
View article: The Impact of Extreme Weather on Dengue Fever in Guangzhou, China: A Zero‐Inflated Negative Binomial Spatial Lag Analysis
The Impact of Extreme Weather on Dengue Fever in Guangzhou, China: A Zero‐Inflated Negative Binomial Spatial Lag Analysis Open
Climate change intensifies extreme weather, which in turn influences infectious disease transmission. As a dengue fever (DF) hotspot, Guangzhou lacks research on how extreme weather characteristics and spatial factors interact to shape DF …
View article: P07.13.A ENHANCING NEUROSURGICAL GUIDANCE IN GLIOBLASTOMA USING NITROGEN VACANT (NV) DIAMOND QUANTUM SENSING
P07.13.A ENHANCING NEUROSURGICAL GUIDANCE IN GLIOBLASTOMA USING NITROGEN VACANT (NV) DIAMOND QUANTUM SENSING Open
BACKGROUND Accurate intraoperative delineation of tumor from eloquent brain is critical for safe and efficient glioblastoma resection. Conventional neuro-navigation offers anatomical guidance but lacks real-time functional feedback and is …
View article: Beyond morphotropic phase boundaries: Atomic-scale mechanism unlocks thermal-stable high-κ performance in HfO2 via coherent interfaces
Beyond morphotropic phase boundaries: Atomic-scale mechanism unlocks thermal-stable high-κ performance in HfO2 via coherent interfaces Open
CMOS-compatible HfO2-based high-κ dielectrics are pivotal for next-generation electronics in the post-Moore’s Law era. However, establishing coherent interfaces via morphotropic phase boundaries (MPBs) across the tetragonal (t) and orthorh…
View article: Distinct orbital contributions to electronic and magnetic structures in La$_{4}$Ni$_{3}$O$_{10}$
Distinct orbital contributions to electronic and magnetic structures in La$_{4}$Ni$_{3}$O$_{10}$ Open
High-T$_c$ superconductivity has recently been discovered in Ruddlesden-Popper phase nickelates under pressure, where the low-energy electronic structure is dominated by Ni $d_{x^2 - y^2}$ and $d_{z^2}$ orbitals. However, the respective ro…
View article: Unleashing pyroelectricity enhancement via phase transition–driven defect alignment in KNN-based ferroelectrics
Unleashing pyroelectricity enhancement via phase transition–driven defect alignment in KNN-based ferroelectrics Open
The pyroelectric effect plays a critical role in thermal imaging and energy harvesting. Despite extensive efforts to enhance performance through doping and composite engineering, the mechanisms underlying defect dipole coupling with phase …
View article: Comprehensive Evaluation Study on the Fracturability of Deep Coal Rock in the Northern Margin of Qaidam Basin
Comprehensive Evaluation Study on the Fracturability of Deep Coal Rock in the Northern Margin of Qaidam Basin Open
In recent years, with the decline in resource quality, the Qaidam Basin has changed its exploration approach and gradually explored deeper and deeper into the source. Coal rocks were interpreted from the Jurassic in the northern margin of …
View article: Molecular mechanism of LncRNA MALAT1 in regulating hepatocellular carcinoma progression via the miR-383-5p/PRKAG1 axis and its role in the tumor immune microenvironment
Molecular mechanism of LncRNA MALAT1 in regulating hepatocellular carcinoma progression via the miR-383-5p/PRKAG1 axis and its role in the tumor immune microenvironment Open
Background Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor worldwide, and its development is closely associated with dysregulated non-coding RNA expression. The long non-coding RNA MALAT1 is overexpressed in multiple c…
View article: Reframing Adaptive Forest Management to Sustain Ecosystem Services Under Climate Change
Reframing Adaptive Forest Management to Sustain Ecosystem Services Under Climate Change Open
Developing effective forest management plans to address the threats posed by global climate change has garnered widespread attention worldwide. A prerequisite for successful adaptation is the ability to forecast and understand how climatic…
View article: Characterization of the NFAT Gene Family in Grass Carp (Ctenopharyngodon idellus) and Functional Analysis of NFAT1 During GCRV Infection
Characterization of the NFAT Gene Family in Grass Carp (Ctenopharyngodon idellus) and Functional Analysis of NFAT1 During GCRV Infection Open
Nuclear factors of activated T cells (NFATs) are pivotal regulatory factors of immune responses, primarily by modulating T cell activity and regulating inflammatory cytokine gene transcription. The grass carp reovirus (GCRV) triggers a ser…
View article: Tailoring Polarization Homogeneity in Discontinuous-Columnar Bi(Fe,Mn)O3 Thin Films through Strain Engineering via Controlled Dislocation Self-Assembly
Tailoring Polarization Homogeneity in Discontinuous-Columnar Bi(Fe,Mn)O3 Thin Films through Strain Engineering via Controlled Dislocation Self-Assembly Open
Strain engineering in ferroelectric thin films is crucial for advancing next-generation electronic devices, yet conventional approaches relying on dislocation-density approaches often compromise structural integrity and electromechanical p…
View article: HPInet: Interpretable prediction of Host-Pathogen protein-protein Interactions using a transformer-based neural network
HPInet: Interpretable prediction of Host-Pathogen protein-protein Interactions using a transformer-based neural network Open
Gram-negative bacteria utilize a series of secretion systems (T1SS-T10SS) to deliver secreted effector proteins (T1SE-T10SE) into host cells, leading to infections and diseases. Understanding the interactions between these effector protein…
View article: The Impact of Helicobacter pylori Infection on Retinal Nerve Fiber Layer and Macula.
The Impact of Helicobacter pylori Infection on Retinal Nerve Fiber Layer and Macula. Open
H. pylori infection may be associated with localized defects in the RNFL, which could serve as early indicators of glaucoma, and it may also be potentially linked to accelerated progression of macular degeneration.
View article: A novel deep learning system for automated diagnosis and grading of lumbar spinal stenosis based on spine MRI: model development and validation
A novel deep learning system for automated diagnosis and grading of lumbar spinal stenosis based on spine MRI: model development and validation Open
OBJECTIVE The study aimed to develop a single-stage deep learning (DL) screening system for automated binary and multiclass grading of lumbar central stenosis (LCS), lateral recess stenosis (LRS), and lumbar foraminal stenosis (LFS). METHO…