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View article: Immune profiling in oncology: bridging the gap between technology and treatment
Immune profiling in oncology: bridging the gap between technology and treatment Open
View article: Nanobodies targeting cytokines for the amelioration of autoimmune diseases
Nanobodies targeting cytokines for the amelioration of autoimmune diseases Open
Autoimmune diseases are driven by dysregulated cytokine networks, where excessive cytokines such as TNF-α, IL-6, IL-17, and IL-23 promote chronic inflammation and tissue damage. While monoclonal antibodies effectively neutralise these cyto…
View article: A Circular Economy Strategy for Repurposing Heparin Manufacturing By‐Products as Anti‐Inflammatory Therapeutics
A Circular Economy Strategy for Repurposing Heparin Manufacturing By‐Products as Anti‐Inflammatory Therapeutics Open
Heparin manufacturing generates significant volumes of by‐products, which are typically treated as waste, and whose potential as a source of alternative bioactive materials is yet to be fully developed. Here, we employed a circular economy…
View article: Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs
Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs Open
Exosomes, containing molecular constituents of their cell of origin, including proteins and nucleic acids, were first discovered in immature red blood cells in 1983. Excellent intercell communication can be achieved by shuttling these vari…
View article: Development of an innovative approach for early diagnosis of cervical cancer using TCR‑like antibodies targeting HPV18 E6 and E7 peptides
Development of an innovative approach for early diagnosis of cervical cancer using TCR‑like antibodies targeting HPV18 E6 and E7 peptides Open
Cervical cancer is the fourth most prevalent cancer among female patients globally, largely due to persistent infections with high‑risk human papillomavirus (HPV). Viral oncoproteins E6 and E7, produced by HPV, serve a role in driving cell…
View article: Current photodynamic therapy and emerging synergies in oncology
Current photodynamic therapy and emerging synergies in oncology Open
Cancer treatment faces ongoing challenges owing to the diverse cancer types and drawbacks of traditional therapies, prompting the search for less invasive alternatives. Photodynamic therapy (PDT) is a non-intrusive approach that uses photo…
View article: Advancement in diagnostic approaches for latent tuberculosis: distinguishing recent from remote infections
Advancement in diagnostic approaches for latent tuberculosis: distinguishing recent from remote infections Open
Tuberculosis (TB) remains as a significant global health threat to date, with latent TB infection (LTBI) serving as a major reservoir for future active disease cases. A practical approach to an effective control and eradication of TB hence…
View article: Aptamer based immunotherapy: a potential solid tumor therapeutic
Aptamer based immunotherapy: a potential solid tumor therapeutic Open
Aptamer-based immunotherapy can be a new hope for treating solid tumors with personalized and specific approaches toward cancer therapies. Aptamers are small synthetic single-stranded nucleic acids that may bring in a paradigm shift in tre…
View article: Investigating the Diagnostic and Therapeutic Potential of a T Cell Receptor (TCR)-like single Domain Antibody (sDAb)-Human IgG1 Antibody against Heat Shock Protein (HSP) 16KDa/HLA-A2 for Latent Tuberculosis
Investigating the Diagnostic and Therapeutic Potential of a T Cell Receptor (TCR)-like single Domain Antibody (sDAb)-Human IgG1 Antibody against Heat Shock Protein (HSP) 16KDa/HLA-A2 for Latent Tuberculosis Open
Heat shock protein 16-kDa (HSP 16-kDa) is essential for the survival of Mycobacterium tuberculosis (M. tuberculosis) during the latent period; hence, a peptide–MHC presentation of HSP 16-kDa could be a potential diagnostic and therapeutic …
View article: Designing molecules: directing stem cell differentiation
Designing molecules: directing stem cell differentiation Open
Stem cells have been widely applied in regenerative and therapeutic medicine for their unique regenerative properties. Although much research has shown their potential, it remains tricky in directing stem cell differentiation. The advancem…
View article: Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges
Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges Open
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy targeting cancer cells via the generation of chimeric antigen receptors on NK cells which recognize specific cancer antigens. CAR-NK cell therapy is ga…
View article: Evaluation of Lentiviral Based Gene Delivery System in Adherent and Suspension in vitro Cell Models
Evaluation of Lentiviral Based Gene Delivery System in Adherent and Suspension in vitro Cell Models Open
Lentiviruses are a highly robust gene delivery system capable of in vitro and in vivo gene transfer into multiple cell types. Recent fourth-generation lentiviral systems have been designed for enhanced safety, however, the increased recomb…
View article: Effects of polystyrene nanoplastic exposure on energy metabolism, lipid metabolism, and amino acid changes in Monopterus albus
Effects of polystyrene nanoplastic exposure on energy metabolism, lipid metabolism, and amino acid changes in Monopterus albus Open
Nanoplastics (NPs) have emerged as contaminants in recent years and have attracted widespread attention because of their ecotoxicological effects. This study aimed to document the effects of different concentrations of NPs on the Monopteru…
View article: Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through Open
Neurodegenerative diseases are adult-onset neurological conditions that are notoriously difficult to model for drug discovery and development because most models are unable to accurately recapitulate pathology in disease-relevant cells, ma…
View article: Intestinal stem cells and gut microbiota therapeutics: hype or hope?
Intestinal stem cells and gut microbiota therapeutics: hype or hope? Open
The vital role of the intestines as the main site for the digestion and absorption of nutrients for the body continues subconsciously throughout one’s lifetime, but underneath all the complex processes lie the intestinal stem cells and the…
View article: Linker-mediated oriented antibody immobilisation strategies for a more efficient immunosensor and diagnostic applications: A review
Linker-mediated oriented antibody immobilisation strategies for a more efficient immunosensor and diagnostic applications: A review Open
The conjugation of antibodies onto the solid surface in a well-oriented manner has a profound impact on the sensitivity and limit of detection of an immunoassay. The chosen method of immobilisation significantly influences the interaction …
View article: Generation of peptides using phage display technology for cancer diagnosis and molecular imaging
Generation of peptides using phage display technology for cancer diagnosis and molecular imaging Open
View article: Effectiveness of Booster Vaccinations on the Control of COVID-19 during the Spread of Omicron Variant in Malaysia
Effectiveness of Booster Vaccinations on the Control of COVID-19 during the Spread of Omicron Variant in Malaysia Open
(1) Background: The assessment of vaccine effectiveness against the Omicron variant is vital in the fight against COVID-19, but research on booster vaccine efficacy using nationwide data was lacking at the time of writing. This study inves…
View article: MSCs vs. iPSCs: Potential in therapeutic applications
MSCs vs. iPSCs: Potential in therapeutic applications Open
Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal and multilineage differentiation capacity, immunomodulator…
View article: Integrase deficient lentiviral vector: prospects for safe clinical applications
Integrase deficient lentiviral vector: prospects for safe clinical applications Open
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to i…
View article: Expression of mammalian proteins for diagnostics and therapeutics: a review
Expression of mammalian proteins for diagnostics and therapeutics: a review Open
View article: CAR-T Cells/-NK Cells in Cancer Immunotherapy and the Potential of MSC to Enhance Its Efficacy: A Review
CAR-T Cells/-NK Cells in Cancer Immunotherapy and the Potential of MSC to Enhance Its Efficacy: A Review Open
The chimeric antigen receptor (CAR) plays a dynamic role in targeting tumour-associated antigens in cancer cells. This novel therapeutic discovery combines fragments of monoclonal antibodies with the signalling and co-stimulatory domains t…
View article: The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic
The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic Open
2020 will be marked in history for the dreadful implications of the COVID-19 pandemic that shook the world globally. The pandemic has reshaped the normality of life and affected mankind in the aspects of mental and physical health, financi…
View article: CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy
CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy Open
Background and Objectives: Abnormal expressions of CD74 and human leukocyte antigen-DR alpha (HLA-DRA) have been reported in various cancers, though their roles in cervical cancer remain unclear. This study aimed to evaluate the gene and p…
View article: Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through
Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through Open
Lentiviral vectors (LVs) play an important role in gene therapy and have proven successful in clinical trials. LVs are capable of integrating specific genetic materials into the target cells and allow for long-term expression of the cDNA o…
View article: The Establishment of In-Vitro Human Induced Pluripotent Stem Cell-Derived Neurons
The Establishment of In-Vitro Human Induced Pluripotent Stem Cell-Derived Neurons Open
View article: Immunomodulation and Regenerative Capacity of MSCs for Long-COVID
Immunomodulation and Regenerative Capacity of MSCs for Long-COVID Open
The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading …
View article: Antibody-Dependent Cell-Mediated Cytotoxicity Through Natural Killer(NK) Cells: Unlocking NK Cells for Future Immunotherapy
Antibody-Dependent Cell-Mediated Cytotoxicity Through Natural Killer(NK) Cells: Unlocking NK Cells for Future Immunotherapy Open
Background: Natural killer (NK) cells have potent effector functions that can be further im-proved for therapeutic purposes through antibody-dependent cell-mediated cytotoxicity (ADCC). Specific killing of virus-infected cells and cancer c…
View article: The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy
The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy Open
Cervical cancer is ranked as the fourth most common cancer in women worldwide. Monoclonal antibody has created a new dimension in the immunotherapy of many diseases, including cervical cancer. The antibody's ability to target various aspec…
View article: Efficacy of early initiation of ivabradine treatment in patients with acute heart failure: rationale and design of SHIFT‐AHF trial
Efficacy of early initiation of ivabradine treatment in patients with acute heart failure: rationale and design of SHIFT‐AHF trial Open
Aims Elevated heart rate (HR) in heart failure (HF) is associated with worse outcomes, particularly in acute HF (AHF). HR reduction with ivabradine reduces cardiovascular events in HF patients with reduced ejection fraction. The present tr…