Weidong Zhang
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View article: Visible Light-Driven Deracemization of α-Aryl Ketones by Synergistic Aryl Thiol and Chiral Phosphoric Acid Catalysis
Visible Light-Driven Deracemization of α-Aryl Ketones by Synergistic Aryl Thiol and Chiral Phosphoric Acid Catalysis Open
View article: An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery
An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery Open
High-throughput technologies now produce a wide array of omics data, from genomic and transcriptomic profiles to epigenomic and proteomic measurements. Integrating multiple omics layers measured on the same samples can reveal cross-layer m…
View article: Integrated Multi‐Omics Profiling to Characterize Molecular Subtypes and Reveal Potential Therapeutic Strategies for Colorectal Cancer
Integrated Multi‐Omics Profiling to Characterize Molecular Subtypes and Reveal Potential Therapeutic Strategies for Colorectal Cancer Open
Colorectal cancer (CRC) is a complex and heterogeneous disease with limited effective treatment options. To investigate the molecular features and potential therapeutic strategies for CRC patients, including both early‐onset colorectal can…
View article: Biomass Chitosan and Phytic Acid Synergistic Modified Paper with Enhanced Oil/Water Resistance for Eco-Friendly Food Packaging
Biomass Chitosan and Phytic Acid Synergistic Modified Paper with Enhanced Oil/Water Resistance for Eco-Friendly Food Packaging Open
The development of novel food packaging materials with both eco-friendly and highly oil-resistant has been identified as a critical challenge in the food packaging industry. Herein, a facile strategy for fabricating food packaging paper wi…
View article: Using electronic health records to improve cardiovascular-kidney-metabolic health: a protocol for the China Cardiovascular-Kidney-Metabolic Cohort-WeinAn REsearch (CKM-CARE)
Using electronic health records to improve cardiovascular-kidney-metabolic health: a protocol for the China Cardiovascular-Kidney-Metabolic Cohort-WeinAn REsearch (CKM-CARE) Open
Introduction The ageing population faces a growing burden of poor cardiovascular-kidney-metabolic (CKM) health, which is receiving increasing attention globally. The proposed China Cardiovascular-Kidney-Metabolic Cohort-Weinan Research (CK…
View article: Hyocholic Acid Species as the Key Modulator for Cecal Epithelial Homeostasis in Low-Birth-Weight Piglets
Hyocholic Acid Species as the Key Modulator for Cecal Epithelial Homeostasis in Low-Birth-Weight Piglets Open
Background: Low birth weight (LBW) is correlated with gut microbiota dysbiosis and intestinal barrier function disruption, increasing susceptibility to enteric diseases. These alterations underscore the critical need to identify key regula…
View article: Influence of Solvent Effects on the Photophysical Properties of Europium Amino Acid Complexes
Influence of Solvent Effects on the Photophysical Properties of Europium Amino Acid Complexes Open
Concentration quenching is mainly caused by energy transfer and cross relaxation between luminescent centers. As the concentration of luminescent centers increases, the distance between them decreases, making it easier for energy to be tra…
View article: Remimazolam alleviates hippocampal neuronal injury in an in vitro Alzheimer’s disease model by promoting PINK1/Parkin-mediated mitophagy
Remimazolam alleviates hippocampal neuronal injury in an in vitro Alzheimer’s disease model by promoting PINK1/Parkin-mediated mitophagy Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the pathological accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau proteins. Remimazolam (RMZ), a novel ultra-short-acting benzodiazepin…
View article: Liming enhances soil priming effect in Chinese fir plantation induced by glycine rather than glucose and oxalic acid
Liming enhances soil priming effect in Chinese fir plantation induced by glycine rather than glucose and oxalic acid Open
Liming is a widely adopted strategy to mitigate soil acidification and enhance forest productivity. However, the extent to which liming modulates forest soil priming effects, particularly those induced by distinct root exudate types, remai…
View article: Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects
Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects Open
View article: Chloroacetic acids induce skin aging via cGAS/STING/NF-κB pathway in HaCaT cells, human explants and rats
Chloroacetic acids induce skin aging via cGAS/STING/NF-κB pathway in HaCaT cells, human explants and rats Open
Chloroacetic acids, including monochloroacetic acid (MCA), dichloroacetic acid (DCA), and trichloroacetic acid (TCA), are non-volatile disinfection by-products. They are frequently detected at high concentrations in swimming pools, raising…
View article: Linking temperature dependency of root litter decomposition to root order: a multi-species incubation study
Linking temperature dependency of root litter decomposition to root order: a multi-species incubation study Open
View article: Efficient Large Language Model Fine-Tuning with Joint Structural Pruning and Parameter Sharing
Efficient Large Language Model Fine-Tuning with Joint Structural Pruning and Parameter Sharing Open
This paper addresses the challenges of high computational cost and severe parameter redundancy in the fine-tuning of large language models. It proposes an efficient fine-tuning algorithm that integrates structural pruning with parameter sh…
View article: Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson’s Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation
Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson’s Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation Open
Geissoschizine methyl ether-(GME) is an indole alkaloid isolated from Uncariae Ramulus Cum Uncis, known for its various biological activities, including antioxidant effects, and neuroprotective properties. However, it has not yet been conf…
View article: Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty
Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty Open
Fospropofol disodium may be a viable alternative in settings where injection pain and PONV are primary concerns, provided that hemodynamic stability is actively managed in elderly THA patients, with non-inferior efficacy in preventing PND …
View article: Guideline Concordance of Chronic Kidney Disease Testing Remains Low in Patients with Diabetes and Hypertension: Real-World Evidence from a City in Northwest China
Guideline Concordance of Chronic Kidney Disease Testing Remains Low in Patients with Diabetes and Hypertension: Real-World Evidence from a City in Northwest China Open
Introduction: This study aimed to evaluate the guideline concordance of chronic kidney disease (CKD) testing among high-risk patients in a city in Northwest China and identify key factors influencing testing practices. Methods: A retrospec…
View article: Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice
Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice Open
View article: Association of the atherogenic index of plasma and high-sensitivity C-reactive protein with incident cardiovascular disease: evidence from a national cohort of middle-aged and older Chinese adults
Association of the atherogenic index of plasma and high-sensitivity C-reactive protein with incident cardiovascular disease: evidence from a national cohort of middle-aged and older Chinese adults Open
Background The atherogenic index of plasma (AIP), an emerging biomarker of lipid dysregulation, and high-sensitivity C-reactive protein (hs-CRP), an established marker of inflammation, are both implicated in the development of cardiovascul…
View article: Visual illusion in male self-assessment of penile dimensions: a clinical study on penile length perception bias between flaccid and erect states
Visual illusion in male self-assessment of penile dimensions: a clinical study on penile length perception bias between flaccid and erect states Open
Background Despite the significance of penile dimensions in male health and self-perception, there is a lack of population-specific references and understanding of self-assessment biases. Aim To establish population-specific references and…
View article: Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies
Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies Open
View article: Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression
Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression Open
Despite the high sensitivity of estrogen receptor positive (ER + ) breast cancer to endocrine therapy, many patients have primary resistance or develop resistance to endocrine therapies. Acquired resistance to endocrine therapy is a great …
View article: Discovery of 146.8 s pulsations from EP J005146.9−730930, a new transient Be/X-ray binary in the SMC
Discovery of 146.8 s pulsations from EP J005146.9−730930, a new transient Be/X-ray binary in the SMC Open
Recent observations of the Small Magellanic Cloud (SMC) with Einstein Probe (EP) revealed a new transient X-ray source, most likely identified as Be/X-ray binary. To characterise the X-ray properties of EP J005146.9–730930 and in particula…
View article: Experimental Study on Mechanical Properties of Microbially Modified Slag Based on CT Technology
Experimental Study on Mechanical Properties of Microbially Modified Slag Based on CT Technology Open
Microbial Induced Calcium Carbonate Precipitation (MICP) can effectively improve the residual soil to improve the physical and mechanical properties and significantly enhance its compressive properties. In this paper, the mechanical proper…
View article: Autonomous Resource Management in Microservice Systems via Reinforcement Learning
Autonomous Resource Management in Microservice Systems via Reinforcement Learning Open
This paper proposes a reinforcement learning-based method for microservice resource scheduling and optimization, aiming to address issues such as uneven resource allocation, high latency, and insufficient throughput in traditional microser…
View article: The toxic components, toxicological mechanism and effective antidote for Gelsemium elegans poisoning
The toxic components, toxicological mechanism and effective antidote for Gelsemium elegans poisoning Open
View article: The effects of long-term co-exposure to nanocarbon black particles and benzo[a]pyrene on ROS levels and the AKT/P27 signaling pathway in BEAS-2B cells
The effects of long-term co-exposure to nanocarbon black particles and benzo[a]pyrene on ROS levels and the AKT/P27 signaling pathway in BEAS-2B cells Open
Background: Long-term co-exposure to nanocarbon black particles (NCBP) and benzo[a]pyrene (B[a]P), as major components of PM2.5, may contribute to respiratory diseases by inducing oxidative damage. However, the molecular mechanisms underly…
View article: Unified Instruction Encoding and Gradient Coordination for Multi-Task Language Models
Unified Instruction Encoding and Gradient Coordination for Multi-Task Language Models Open
This paper conducts an in-depth study on the theoretical foundations and optimization mechanisms of instruction tuning for multi-task generalization. We propose a unified, parameter-efficient tuning framework that integrates instruction em…
View article: ABS0650 ECONOMIC BURDEN AND LIFE QUALITY OF IgG4-RELATED DISEASE IN CHINA: A COMPARATIVE ANALYSIS OF THREE TREATMENT REGIMENS
ABS0650 ECONOMIC BURDEN AND LIFE QUALITY OF IgG4-RELATED DISEASE IN CHINA: A COMPARATIVE ANALYSIS OF THREE TREATMENT REGIMENS Open
View article: Screening, Identification, and Fermentation of Brevibacillus laterosporus YS-13 and Its Impact on Spring Wheat Growth
Screening, Identification, and Fermentation of Brevibacillus laterosporus YS-13 and Its Impact on Spring Wheat Growth Open
The low availability of phosphorus (P) in soil has become a critical factor limiting crop growth and agricultural productivity. This study aimed to isolate and evaluate a bacterial strain with high phosphate-solubilizing capacity to improv…
View article: Entity Boundary Detection in Social Texts Using BiLSTM-CRF with Integrated Social Features
Entity Boundary Detection in Social Texts Using BiLSTM-CRF with Integrated Social Features Open
This study addresses the challenges of unstructured expressions, semantic ambiguity, and noise interference in named entity recognition tasks on social texts. A recognition method is proposed that integrates the BiLSTM-CRF model with multi…