Jun Yoshino
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View article: Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice
Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice Open
Post-cardiac arrest brain injury (PCABI) is the leading cause of death and disability following cardiac arrest (CA). Nicotinamide adenine dinucleotide (NAD + ) depletion after CA contributes to neuronal injury, while nicotinamide mononucle…
View article: Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice
Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice Open
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme and a central factor in energy metabolism. Nicotinamide phosphoribosyltransferase (NAMPT) maintains the cellular NAD+ pool by synthesizing the NAD+ precursor, nicotinamide mononu…
View article: Vascular Endothelial <scp>NAMPT</scp> ‐Mediated <scp>NAD</scp> <sup>+</sup> Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice
Vascular Endothelial <span>NAMPT</span> ‐Mediated <span>NAD</span> <sup>+</sup> Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice Open
Aging is associated with metabolic dysfunction and cardiovascular abnormalities. Defective nicotinamide adenine dinucleotide (NAD + ) biosynthesis correlates with aging and aging‐associated complications. However, the precise molecular mec…
View article: Combined blood pressure and pulse rate as a new risk marker for mortality in hemodialysis patients
Combined blood pressure and pulse rate as a new risk marker for mortality in hemodialysis patients Open
View article: A High-Fat Diet Increases Kidney Fibrosis Through Regulating TGF-β and PDGF-β Signaling Pathways in Normotensive and Hypertensive Rat Models
A High-Fat Diet Increases Kidney Fibrosis Through Regulating TGF-β and PDGF-β Signaling Pathways in Normotensive and Hypertensive Rat Models Open
Hypertension and obesity are well-established risk factors for chronic kidney disease (CKD). This study investigates the interaction between these two factors in CKD using animal models. Twelve-week-old normotensive Wistar Kyoto (WKY), spo…
View article: Intraabdominal fat-free volume, but not fat volume, predicts the development of peritonitis in patients on peritoneal dialysis: a retrospective cohort study
Intraabdominal fat-free volume, but not fat volume, predicts the development of peritonitis in patients on peritoneal dialysis: a retrospective cohort study Open
Introduction Increased intraabdominal fat volume (IAFV) is associated with systemic inflammation and various cardiometabolic diseases. However, the clinical implication of IAFV in patients on peritoneal dialysis (PD) is unclear. In additio…
View article: ASSESSMENT OF COMPOUND FLOODING FOR ISE BAY, JAPAN USING TYPHOON TRACK ENSEMBLE EXPERIMENTS
ASSESSMENT OF COMPOUND FLOODING FOR ISE BAY, JAPAN USING TYPHOON TRACK ENSEMBLE EXPERIMENTS Open
Recent typhoon cases have clearly demonstrated the danger of compound flooding by large storm surges associated with intensified typhoons and floods from upstream. Integrated numerical models that solve for typhoons, storm surges, and floo…
View article: Erratum to “Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan” [Kidney International Reports Volume 10, Issue 4, April 2025, Pages 1063-1075]
Erratum to “Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan” [Kidney International Reports Volume 10, Issue 4, April 2025, Pages 1063-1075] Open
[This corrects the article DOI: 10.1016/j.ekir.2025.01.023.].
View article: DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages
DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages Open
View article: Topographically driven vigorous vertical mixing supports mesoscale biological production in the Tsugaru Gyre
Topographically driven vigorous vertical mixing supports mesoscale biological production in the Tsugaru Gyre Open
The Tsugaru Strait is a critical conduit linking the Sea of Japan and the Pacific Ocean and is characterized by a vigorous eastward current. Here, we use high-resolution surface current data acquired from a high-frequency radar system in c…
View article: Taurine supplementation improves physical activity level in a hemodialysis patient with mitochondrial disease: a case report
Taurine supplementation improves physical activity level in a hemodialysis patient with mitochondrial disease: a case report Open
View article: Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model
Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model Open
Sarcopenia, a serious consequence of chronic kidney disease (CKD), is driven by elevated myostatin (MSTN), a key inhibitor of muscle growth. This study explored the potential of an MSTN-specific antisense oligonucleotide (ASO) in reversing…
View article: A case of posterior and reversible encephalopathy syndrome in a patient previously undiagnosed with lupus nephritis
A case of posterior and reversible encephalopathy syndrome in a patient previously undiagnosed with lupus nephritis Open
Posterior reversible encephalopathy syndrome (PRES) is a rare clinico-neuroradiologic disease associated with various conditions, such as hypertension, eclampsia, chronic kidney disease, and autoimmune diseases. Here, we present the case o…
View article: Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan
Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan Open
View article: Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring Open
Tissue-level oscillation is achieved by tissue-intrinsic clocks along with network-dependent signals originating from distal organs and organismal behavior. Yet, it remains unexplored whether maternal circadian rhythms during pregnancy inf…
View article: HIGHER ACCURACY OF WAVE ESTIMATION IN COMPLEX TERRAIN WATERS BY STATISTICAL CORRECTION USING DIRECTIONAL WAVE TRANSMISSION COEFFICIENTS
HIGHER ACCURACY OF WAVE ESTIMATION IN COMPLEX TERRAIN WATERS BY STATISTICAL CORRECTION USING DIRECTIONAL WAVE TRANSMISSION COEFFICIENTS Open
View article: EVALUATION OF GLOBAL WARMING IMPACTS ON STEERING CURRENTS OF TYPHOONS USING THE PIECEWISE POTENTIAL VORTICITY INVERSION
EVALUATION OF GLOBAL WARMING IMPACTS ON STEERING CURRENTS OF TYPHOONS USING THE PIECEWISE POTENTIAL VORTICITY INVERSION Open
View article: MAXIMUM POTENTIAL STORM SURGE ON THE EAST COAST OF HOKKAIDO CONSIDERING THE DEVELOPMENTAL PROCESSES OF A BOMB CYCLONE
MAXIMUM POTENTIAL STORM SURGE ON THE EAST COAST OF HOKKAIDO CONSIDERING THE DEVELOPMENTAL PROCESSES OF A BOMB CYCLONE Open
View article: PARAMETER ESTIMATION OF EMPIRICAL TYPHOON MODEL USING VARIATIONAL DATA ASSIMILATION AND ITS VERIFICATION FOR STORM SURGE ESTIMATION
PARAMETER ESTIMATION OF EMPIRICAL TYPHOON MODEL USING VARIATIONAL DATA ASSIMILATION AND ITS VERIFICATION FOR STORM SURGE ESTIMATION Open
View article: Adipose tissue biology and effect of weight loss in women with lipedema
Adipose tissue biology and effect of weight loss in women with lipedema Open
Lipedema is a lipodystrophic disease that is typically characterized by a marked increase in lower-body subcutaneous adipose tissue that is purported to have increased inflammation and fibrosis, impaired microvascular/lymphatic circulation…
View article: Adipose tissue biology and effect of weight loss in women with lipedema
Adipose tissue biology and effect of weight loss in women with lipedema Open
Lipedema is a lipodystrophic disease that is typically characterized by a marked increase in lower-body subcutaneous adipose tissue that is purported to have increased inflammation and fibrosis, impaired microvascular/lymphatic circulation…
View article: The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study
The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study Open
IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide and leads to end-stage kidney disease. The proteinuria selectivity index (PSI) has been used to assess the prognosis in nephrotic syndrome, but its pred…
View article: Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice
Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice Open
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacy…
View article: Hepatocyte MMP14 mediates liver and inter-organ inflammatory responses to diet-induced liver injury
Hepatocyte MMP14 mediates liver and inter-organ inflammatory responses to diet-induced liver injury Open
The matrix metalloproteinase MMP14 is a ubiquitously expressed, membrane-bound, secreted endopeptidase that proteolyzes substrates to regulate development, signaling, and metabolism. However, the spatial and contextual events inciting MMP1…
View article: Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging Open
Defective NAD + metabolism is associated with aging and age-associated metabolic diseases. In the present study, we provided in-depth metabolic assessments in female mice with adipocyte-specific inactivation of a key NAD + biosynthetic enz…
View article: Investigation of compound occurrence of storm surge and river flood in Mikawa Bay, Japan, using typhoon track ensemble experiments
Investigation of compound occurrence of storm surge and river flood in Mikawa Bay, Japan, using typhoon track ensemble experiments Open
The risk of high river flow and peak storm surge superimposing in the estuary of small-and medium-sized rivers can be more severe during typhoon landfalls than at other times. In this study, 30 cases of typhoon track ensemble experiments f…
View article: Efficacy of sucrose and povidone–iodine mixtures in peritoneal dialysis catheter exit-site care
Efficacy of sucrose and povidone–iodine mixtures in peritoneal dialysis catheter exit-site care Open
View article: Combining hemodialysis with peritoneal dialysis improves cognitive function: a three-case report
Combining hemodialysis with peritoneal dialysis improves cognitive function: a three-case report Open
View article: Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity
Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity Open
View article: Multiple Neuroendocrine Tumors with Fat Replacement of the Pancreatic Body and Tail Treated with Pancreaticoduodenectomy without Pancreaticojejunostomy: A Case Report
Multiple Neuroendocrine Tumors with Fat Replacement of the Pancreatic Body and Tail Treated with Pancreaticoduodenectomy without Pancreaticojejunostomy: A Case Report Open
症例は64歳の女性で,耐糖能異常を指摘され,腹部超音波検査を施行し膵頭部腫瘤を認めた.精査で膵神経内分泌腫瘍の診断となり,亜全胃温存膵頭十二指腸切除術を施行した.術前のCTでは膵体尾部は周囲の脂肪と判別困難であり,術中同様に膵体尾部の膵実質は脂肪と類似しており,膵体尾部の脂肪置換と判断した.膵断端の迅速病理組織診断では外分泌線は消失し主膵管は同定不能であったが,ランゲルハンス島は残存しており残膵は切除せず非再建とした.術後は膵液瘻を認めず,血糖コントロールは比較的良好であっ…