Chuanjun Zhuo
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View article: Type 1 Diabetes as a Causal Risk Factor for Suicide or Selfharm: A Bidirectional Mendelian Randomization Study
Type 1 Diabetes as a Causal Risk Factor for Suicide or Selfharm: A Bidirectional Mendelian Randomization Study Open
View article: Network pharmacology and molecular docking-based strategy to determine the potential mechanism for escitalopram-mediated long QT syndrome
Network pharmacology and molecular docking-based strategy to determine the potential mechanism for escitalopram-mediated long QT syndrome Open
Based on bioinformatic analysis, escitalopram may affect the electrolyte balance, atherosclerosis, and ion channels implicated in LQTS, providing theoretical clues for follow-up studies.
View article: Shared and unique therapeutic targets of KarXT and clozapine for schizophrenia treatment revealed by network pharmacology and molecular docking analyses: Implications for differential clinical responses
Shared and unique therapeutic targets of KarXT and clozapine for schizophrenia treatment revealed by network pharmacology and molecular docking analyses: Implications for differential clinical responses Open
View article: Paraspinal Muscle Fat Infiltration Predicts Vertebral Refracture After Kyphoplasty: Development and Validation of a Novel Nomogram Model
Paraspinal Muscle Fat Infiltration Predicts Vertebral Refracture After Kyphoplasty: Development and Validation of a Novel Nomogram Model Open
Paraspinal FI is a critical biomarker for post-PKP refracture risk. The nomogram model provides a practical tool for personalized risk stratification, emphasizing the integration of muscle quality assessment into spinal fragility managemen…
View article: The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses
The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses Open
View article: Molecular targets of vortioxetine mediating glioblastoma suppression revealed by gene and protein network analyses and molecular docking simulations
Molecular targets of vortioxetine mediating glioblastoma suppression revealed by gene and protein network analyses and molecular docking simulations Open
Background Vortioxetine is a serotonin reuptake inhibitor and serotonin receptor modulator used for the treatment of major depressive disorder, but recent studies have also reported anticancer effects in models of glioblastoma. Given the w…
View article: Unique and overlapping mechanisms of valbenazine, deutetrabenazine, and vitamin E for tardive dyskinesia
Unique and overlapping mechanisms of valbenazine, deutetrabenazine, and vitamin E for tardive dyskinesia Open
View article: Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study
Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study Open
These findings highlight the distinct signaling pathways and molecular networks involved in prolactin regulation by aripiprazole and amisulpride and provide new insights into the mechanisms of these drugs in schizophrenia treatment. Furthe…
View article: Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities
Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities Open
Low-intensity transcranial focused ultrasound stimulation (tFUS) has recently emerged as a promising neuromodulation technique due to its non-invasive nature, ability to penetrate deeply, and high spatial resolution. On the other hand, the…
View article: Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning
Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning Open
The brain's multi-scale hierarchical organization supports functional segregation and integration. Characterizing the hierarchy of individualized multi-scale functional networks (FNs) is crucial for understanding these fundamental brain pr…
View article: Characterization of the Molecular Mechanisms Underlying Lurasidone‐Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach
Characterization of the Molecular Mechanisms Underlying Lurasidone‐Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach Open
Background Lurasidone monotherapy has been approved for the treatment of bipolar depression. However, several case reports have indicated treatment with lurasidone‐induced acute mania in people with bipolar depression. The mechanism by whi…
View article: Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study
Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study Open
View article: Trajectories of intrinsic capacity decline and related factors in old persons: A 15-year community-based cohort study in Beijing
Trajectories of intrinsic capacity decline and related factors in old persons: A 15-year community-based cohort study in Beijing Open
View article: Network pharmacology and molecular docking to explore mechanisms of clozapine-induced cardiac arrest
Network pharmacology and molecular docking to explore mechanisms of clozapine-induced cardiac arrest Open
Background: Clozapine is superior to all other antipsychotics in treating schizophrenia in terms of its curative efficacy; however, this drug is prescribed only as a last resort in the treatment of schizophrenia, given its potential to ind…
View article: Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK–STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking
Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK–STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking Open
Background Clozapine exhibits significant therapeutic efficacy in schizophrenia, especially treatment‐resistant schizophrenia. However, clozapine can cause agranulocytosis, a fatal adverse effect, and the aim of this study is to explore th…
View article: Deep learning disentangles neuroanatomical heterogeneity in psychotic disorders, psychosis onset and unaffected siblings
Deep learning disentangles neuroanatomical heterogeneity in psychotic disorders, psychosis onset and unaffected siblings Open
View article: KarXT Combines the Partial Benefits of Haloperidol for Positive Symptoms and Sulpiride for Negative Symptoms: Evidence from Computational Biology
KarXT Combines the Partial Benefits of Haloperidol for Positive Symptoms and Sulpiride for Negative Symptoms: Evidence from Computational Biology Open
The new drug KarXT is a combination of xanomeline and trospium. KarXT is a unique antipsychotic that targets muscarinic receptors to reduce the positive and negative symptoms of schizophrenia. Haloperidol affects the positive symptoms and …
View article: Exploring the potential pharmacological mechanism of aripiprazole against hyperprolactinemia based on network pharmacology and molecular docking
Exploring the potential pharmacological mechanism of aripiprazole against hyperprolactinemia based on network pharmacology and molecular docking Open
View article: Exploring the molecular targets of fingolimod and siponimod for treating the impaired cognition of schizophrenia using network pharmacology and molecular docking
Exploring the molecular targets of fingolimod and siponimod for treating the impaired cognition of schizophrenia using network pharmacology and molecular docking Open
The treatment of cognitive impairment in schizophrenia is an unaddressed need due to the absence of novel treatments. Recent studies demonstrated that fingolimod and siponimod have neuroprotective effects in several neuropsychiatric disord…
View article: Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression
Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression Open
It has been revealed that abnormal voxel-mirrored homotopic connectivity (VMHC) is present in patients with schizophrenia, yet there are inconsistencies in the relevant findings. Moreover, little is known about their association with brain…
View article: Trajectories of Intrinsic Capacity Decline and Related Factors in Older People: A 15-Year Community-Based Cohort Study of Dementia in Beijing
Trajectories of Intrinsic Capacity Decline and Related Factors in Older People: A 15-Year Community-Based Cohort Study of Dementia in Beijing Open
View article: Genomic loci influence patterns of structural covariance in the human brain
Genomic loci influence patterns of structural covariance in the human brain Open
Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases. The genetic unde…
View article: Insulin Resistance/Diabetes and Schizophrenia: Potential Shared Genetic Factors and Implications for Better Management of Patients with Schizophrenia
Insulin Resistance/Diabetes and Schizophrenia: Potential Shared Genetic Factors and Implications for Better Management of Patients with Schizophrenia Open
Schizophrenia is a complex psychotic disorder with co-occurring conditions, including insulin resistance and type 2 diabetes (T2D). It is well established that T2D and its precursors (i.e., insulin resistance) are more prevalent in patient…
View article: Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin-6 level in drug-naive patients with first schizophrenia symptoms: a follow-up pilot study
Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin-6 level in drug-naive patients with first schizophrenia symptoms: a follow-up pilot study Open
View article: Identifying canonical and replicable multi‐scale intrinsic connectivity networks in 100k+ <scp>resting‐state fMRI</scp> datasets
Identifying canonical and replicable multi‐scale intrinsic connectivity networks in 100k+ <span>resting‐state fMRI</span> datasets Open
Despite the known benefits of data‐driven approaches, the lack of approaches for identifying functional neuroimaging patterns that capture both individual variations and inter‐subject correspondence limits the clinical utility of rsfMRI an…
View article: Validation of a modified Chinese‐language version of the Davos Assessment of Cognitive Biases Scale (MCL‐DACOBS) in a sample of Chinese patients with schizophrenia
Validation of a modified Chinese‐language version of the Davos Assessment of Cognitive Biases Scale (MCL‐DACOBS) in a sample of Chinese patients with schizophrenia Open
Introduction The Davos Assessment of Cognitive Biases Scale (DACOBS) is widely used to assess cognitive biases in patients who have schizophrenia. However, the lack of a modified Chinese‐language version of the DACOBS (MCL‐DACOBS) preclude…
View article: Low-dose lithium adjunct to quetiapine improves cognitive task performance in mice with MK801-induced long-term cognitive impairment: Evidence from a pilot study
Low-dose lithium adjunct to quetiapine improves cognitive task performance in mice with MK801-induced long-term cognitive impairment: Evidence from a pilot study Open
More pre-clinical and clinical studies are needed to further investigate effective treatment strategies for patients with long-term cognitive impairments, such as chronic schizophrenia.
View article: Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions
Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions Open
View article: Validation and reliability test of Chinese language patient-reported impact of symptoms in schizophrenia scale
Validation and reliability test of Chinese language patient-reported impact of symptoms in schizophrenia scale Open
Background Patient-reported outcomes, or subjective evaluations directly reflecting the patient’s views, feelings, and judgments, are now being used to evaluate the outcomes of care and treatment of people with schizophrenia. In this study…
View article: Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium
Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium Open