Shahrukh K. Hashmi
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View article: Long-term outcomes and GVHD in patients receiving hematopoietic cell transplants abroad: A 14-year UAE multi-center cohort
Long-term outcomes and GVHD in patients receiving hematopoietic cell transplants abroad: A 14-year UAE multi-center cohort Open
Background Hematopoietic cell transplant (HCT) outcomes are well characterized in clinical trials and international registries, but data remain scarce for patients who undergo transplantation abroad and return home for follow-up. While tra…
View article: Basal Ganglia Stroke in Children Following a History of Fall: A Study of Five Cases with Mineralizing Angiopathy
Basal Ganglia Stroke in Children Following a History of Fall: A Study of Five Cases with Mineralizing Angiopathy Open
View article: Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis
Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis Open
Tisagenlecleucel (tisa-cel) is a CD19-directed chimeric antigen receptor T-cell therapy for relapsed/refractory precursor B-cell acute lymphoblastic leukemia (R/R B-ALL). We report infectious complications for 100 days (D100) following tis…
View article: Correction: Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation
Correction: Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation Open
View article: Ruxolitinib in Patients With Corticosteroid-Refractory or Corticosteroid-Dependent Chronic Graft-Versus-Host Disease: 3-Year Final Analysis of the Phase III REACH3 Study
Ruxolitinib in Patients With Corticosteroid-Refractory or Corticosteroid-Dependent Chronic Graft-Versus-Host Disease: 3-Year Final Analysis of the Phase III REACH3 Study Open
In REACH3 (ClinicalTrials.gov identifier: NCT03112603 ), ruxolitinib was investigated versus best available therapy (BAT) for 3 years in patients with steroid-refractory/dependent chronic graft-versus-host-disease (SR/D-cGVHD). Patients re…
View article: Global Access to Multiple Myeloma Therapies
Global Access to Multiple Myeloma Therapies Open
PURPOSE Initial reports indicate that access to contemporary therapies currently used in North America for the treatment of multiple myeloma (MM) varies internationally. No studies have quantitatively reported the extent of disparities in …
View article: High GVHD Prevalence in Travel-Based SCT despite Young Patients and HLA Matching
High GVHD Prevalence in Travel-Based SCT despite Young Patients and HLA Matching Open
Background: Patients from regions without stem cell transplantation (SCT) facilities often seek treatment abroad and return home for post-transplant care. Although extensive data exist on graft-versus-host disease (GVHD) and its risk facto…
View article: Delayed T-cell recovery after hematopoietic cell transplantation is associated with decreased overall survival in adults
Delayed T-cell recovery after hematopoietic cell transplantation is associated with decreased overall survival in adults Open
Allogeneic hematopoietic cell transplantation (allo-HCT) can provide curative treatment for hematologic malignancies but is associated with prolonged lymphopenia that may contribute to an increased risk of infection and relapse, resulting …
View article: Haploidentical, matched-related, and matched-unrelated hematopoietic cell transplant for acute leukemias in the early years of haploidentical transplant implementation in a developing country with a large unrelated donor registry
Haploidentical, matched-related, and matched-unrelated hematopoietic cell transplant for acute leukemias in the early years of haploidentical transplant implementation in a developing country with a large unrelated donor registry Open
Introduction Over the last decades, the donor network for hematopoietic cell transplantation (HCT) has grown exponentially, including unrelated and haploidentical (Haplo) donors. This study aimed to describe HCT outcomes with MSD, Haplo, a…
View article: UAE Consensus on Patient Profiles for Pre-exposure Prophylaxis with Monoclonal Antibodies against COVID-19 in Hematological Malignancies and Immunocompromised States
UAE Consensus on Patient Profiles for Pre-exposure Prophylaxis with Monoclonal Antibodies against COVID-19 in Hematological Malignancies and Immunocompromised States Open
Introduction: Despite significant advancements in COVID-19 treatment and prevention, immunocompromised individuals, particularly those with hematological malignancies, remain at high risk for severe infection and suboptimal vaccine respons…
View article: Dynamic Facial Reanimation for Facial Palsy
Dynamic Facial Reanimation for Facial Palsy Open
This study observed earlier recovery in patients who had undergone single-stage free gracilis muscle transfer with motor innervation from the ipsilateral nerve to the masseter compared to the cross-facial nerve transfer. The oral co…
View article: Novel hierarchical deep learning models predict type of leukemia from whole slide microscopic images of peripheral blood
Novel hierarchical deep learning models predict type of leukemia from whole slide microscopic images of peripheral blood Open
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: P.028 Exploring young adult stroke patients’ lived experience, healthy lifestyle habits, and recommendations for designing innovative brain care-related initiatives
P.028 Exploring young adult stroke patients’ lived experience, healthy lifestyle habits, and recommendations for designing innovative brain care-related initiatives Open
Background: Over the past decade, worldwide stroke incidence has been increasing among young adults (≤65years), which has implications during the most dynamic period of their life. There is a dearth of research exploring young adults strok…
View article: Racial Disparities in Cardiovascular and Cerebrovascular Adverse Events in Patients with Non-Hodgkin Lymphoma: A Nationwide Analysis
Racial Disparities in Cardiovascular and Cerebrovascular Adverse Events in Patients with Non-Hodgkin Lymphoma: A Nationwide Analysis Open
Background and Objectives: Non-Hodgkin lymphoma (NHL) has the sixth-highest malignancy-related mortality in the United States (US). However, inequalities exist in access to advanced care in specific patient populations. We aim to study the…
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: Consensus-Based Expert Recommendations on the Management of Hemophilia A in the Gulf Region
Consensus-Based Expert Recommendations on the Management of Hemophilia A in the Gulf Region Open
Background: Hemophilia A presents a significant health challenge in the Gulf region, where it has an especially high prevalence. There are several unmet needs associated with the management of hemophilia A in the region. The …
View article: Ocular graft host disease after allogeneic stem cell transplant: unique risk factors and outcomes
Ocular graft host disease after allogeneic stem cell transplant: unique risk factors and outcomes Open
Objective The aim of this study was to formulate a retrospective study investigating the ocular findings and associated risk factors in long-term survivors after allogenic-hematopoietic stem cell transplantation (HSCT) in Saudi Arabia. Pat…
View article: Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions
Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions Open
Current advances in cancer therapy have increased survival, emphasizing the need for life quality improvement. Fertility loss is common post-chemotherapy. Current guidelines establish embryo and oocyte cryopreservation to address premature…
View article: Understanding the Importance and Future Directions of Cultural Sensitivity in Healthcare: Developing a Culturally sensitive Patient Experience Framework with Emirati Patients as a Case Study
Understanding the Importance and Future Directions of Cultural Sensitivity in Healthcare: Developing a Culturally sensitive Patient Experience Framework with Emirati Patients as a Case Study Open
In healthcare, patient feedback is pivotal for enhancing care quality, satisfaction, and trust. Cultural factors, as evidenced in previous studies on Emirati patients, significantly shape these perceptions. This paper underscores the unive…
View article: Hematological Malignancies in the UAE
Hematological Malignancies in the UAE Open
Hematologic malignancies make up a substantial portion of overall cancers, and unfortunately, the incidence of hematologic malignancies continues to grow in developed countries. These encompass both inherited and acquired cancers, though c…
View article: Ocular and Oral Complications
Ocular and Oral Complications Open
The craniofacial complex includes the eyes and mouth, and each site has its own set of GVHD- and non-GVHD-related late effects which, if left untreated, can lead to permanent disability.
View article: Graft-versus-host-disease in hematopoietic stem cell transplant recipients from diverse nationalities and transplant centers: a single-center cohort study in the UAE
Graft-versus-host-disease in hematopoietic stem cell transplant recipients from diverse nationalities and transplant centers: a single-center cohort study in the UAE Open
Background : Graft-versus-host-disease (GVHD), affecting 30-50% of cases, is a complex, multisystem disorder contributing to non-relapse mortality. In the UAE, where patients from different nationalities have historically sought transplant…
View article: Cellular senescence in brain aging and cognitive decline
Cellular senescence in brain aging and cognitive decline Open
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, t…
View article: Breaking down the Hierarchy: A New Approach to Leukemia Classification
Breaking down the Hierarchy: A New Approach to Leukemia Classification Open
View article: Severity of Chronic Graft-versus-Host Disease and Late Effects Following Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancy
Severity of Chronic Graft-versus-Host Disease and Late Effects Following Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancy Open
View article: Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis
Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis Open
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a poor prognosis and considered incurable with conventional chemotherapy. Small observational studies reported allogeneic hematopoietic cell trans…
View article: Real-world experience with ponatinib therapy in chronic phase chronic myeloid leukemia: impact of depth of response on survival and prior exposure to nilotinib on arterial occlusive events
Real-world experience with ponatinib therapy in chronic phase chronic myeloid leukemia: impact of depth of response on survival and prior exposure to nilotinib on arterial occlusive events Open
We surveyed the performance of ponatinib, as salvage therapy, in a real-world setting of chronic phase chronic myeloid leukemia (CML-CP). Among 55 consecutive patients (median age 49 years) with relapsed/refractory CML-CP, 35 (64%) had fai…
View article: Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis
Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis Open
Racial/ethnic minorities have demonstrated worse survival after allogeneic hematopoietic cell transplantation (HCT) compared to whites. Whether the racial disparity in HCT outcomes persists in long-term survivors and possibly may be even e…
View article: Impact of Donor Age on Allogeneic Hematopoietic Cell Transplantation Outcomes in Older Adults with Acute Myeloid Leukemia
Impact of Donor Age on Allogeneic Hematopoietic Cell Transplantation Outcomes in Older Adults with Acute Myeloid Leukemia Open