Jun‐biao Xue
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View article: Integrating genomic epidemiology and deep mutational scanning data for prevalence forecasting of SARS-CoV-2 Omicron lineages
Integrating genomic epidemiology and deep mutational scanning data for prevalence forecasting of SARS-CoV-2 Omicron lineages Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continuously circulates and the Omicron variants have mutated into over 2,500 lineages, predicting ensuing prevalent lineages and inflections of dominant lineages is of public he…
View article: An African swine fever virus-specific antibody reactome reveals antigens as potential candidates for vaccine development
An African swine fever virus-specific antibody reactome reveals antigens as potential candidates for vaccine development Open
Developing an efficient and safe vaccine for African swine fever (ASF), a devastating disease of pigs, remains a significant challenge mainly due to limited knowledge of the immune correlates of protection. Identifying protective determina…
View article: STAT5-c-Myc-axis regulates B cell metabolism in vaccinated individuals and COVID-19 recovered patients
STAT5-c-Myc-axis regulates B cell metabolism in vaccinated individuals and COVID-19 recovered patients Open
SARS-CoV-2 infection and vaccination both trigger immune responses. The former leads to naturally acquired immunity, while the latter induces active immunity through artificial means. However, the distinct immune effects of vaccination and…
View article: DeepPFP: a multi-task-aware architecture for protein function prediction
DeepPFP: a multi-task-aware architecture for protein function prediction Open
Deriving protein function from protein sequences poses a significant challenge due to the intricate relationship between sequence and function. Deep learning has made remarkable strides in predicting sequence-function relationships. Howeve…
View article: Age- and Severity-Associated Humoral Immunity Response in COVID-19 Patients: A Cohort Study from Wuhan, China
Age- and Severity-Associated Humoral Immunity Response in COVID-19 Patients: A Cohort Study from Wuhan, China Open
Age has been found to be the single most significant factor in COVID-19 severity and outcome. However, the age-related severity factors of COVID-19 have not been definitively established. In this study, we detected SARS-CoV-2-specific anti…
View article: Longitudinal neutralization activities on authentic Omicron variant provided by three doses of BBIBP‐CorV vaccination during one year
Longitudinal neutralization activities on authentic Omicron variant provided by three doses of BBIBP‐CorV vaccination during one year Open
The majority of people in China have been immunized with the inactivated viral vaccine BBIBP‐CorV. The emergence of the Omicron variant raised the concerns about protection efficacy of the inactivated viral vaccine in China. However, longi…
View article: Identification of sitagliptin binding proteins by affinity purification mass spectrometry
Identification of sitagliptin binding proteins by affinity purification mass spectrometry Open
Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with increasing incidence. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin has been used for the treatment of T2DM worldwide. Although sitagliptin ha…
View article: Specific Pupylation as IDEntity Reporter (SPIDER) for the identification of Protein-Biomolecule interactions
Specific Pupylation as IDEntity Reporter (SPIDER) for the identification of Protein-Biomolecule interactions Open
Protein-biomolecule interactions play pivotal roles in almost all biological processes, the identification of the interacting protein is essential. By combining a substrate-based proximity labelling activity from the pupylation pathway of …
View article: SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages
SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages Open
Age has been found to be one of the main risk factors for the severity and outcome of COVID-19. However, differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown. In this …
View article: One year landscape of the inactivated virus vaccine triggered RBD-specific IgG, IgM and IgA responses against the Omicron variant
One year landscape of the inactivated virus vaccine triggered RBD-specific IgG, IgM and IgA responses against the Omicron variant Open
We reported the first map of vaccine stimulated RBD-specific antibody responses (IgG, IgM and IgA) against the Omicron variant. We generated the map using a protein microarray, by analyzing longitudinal sera collected spanning one year fro…
EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem Open
Antibodies are one of the most important groups of biomolecules for both clinical and basic research and have been developed as potential therapeutics. Affinity is the key feature for biological activity and clinical efficacy of an antibod…
Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patients Open
Our findings might have important implications for improving clinical management of COVID-19 patients.
View article: COVID-ONE-hi: The One-Stop Database for COVID-19-Specific Humoral Immunity and Clinical Parameters
COVID-ONE-hi: The One-Stop Database for COVID-19-Specific Humoral Immunity and Clinical Parameters Open
Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, di…
Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins Open
The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. In this study, we collect 2,360 COVID-19 sera and 601 control sera. We analyze these sera on a protein microar…
View article: Antibody landscape against SARS-CoV-2 proteome revealed significant differences between non-structural/ accessory proteins and structural proteins
Antibody landscape against SARS-CoV-2 proteome revealed significant differences between non-structural/ accessory proteins and structural proteins Open
Summary The immunogenicity of SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. Here we collected 2,360 COVID-19 sera and 601 control sera. We analyzed these sera on a protein microarray…
View article: Antibody dynamics to SARS‐CoV‐2 in asymptomatic COVID‐19 infections
Antibody dynamics to SARS‐CoV‐2 in asymptomatic COVID‐19 infections Open
Background The missing asymptomatic COVID‐19 infections have been overlooked because of the imperfect sensitivity of the nucleic acid testing (NAT). Globally understanding the humoral immunity in asymptomatic carriers will provide scientif…
View article: Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients
Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients Open
Serological test plays an essential role in monitoring and combating COVID-19 pandemic. Recombinant spike protein (S protein), especially S1 protein is one of the major reagents for serological tests. However, the high cost in production o…
View article: Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients Open
Neutralization antibodies and vaccines for treating COVID-19 are desperately needed. For precise development of antibodies and vaccines, the key is to understand which part of SARS-CoV-2 Spike protein is highly immunogenic on a systematic …
View article: Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections
Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections Open
Importance Asymptomatic COVID-19 infections have a long duration of viral shedding and contribute substantially to disease transmission. However, the missing asymptomatic cases have been significantly overlooked because of imperfect sensit…