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View article: Bioorthogonal Chemistry: An Emerging Strategy for Targeted Protein Degradation
Bioorthogonal Chemistry: An Emerging Strategy for Targeted Protein Degradation Open
Targeted protein degradation (TPD) technologies represent a promising strategy to overcome drug resistance associated with traditional small‐molecule inhibitors (SMIs) while targeting traditionally considered nondruggable targets. However,…
View article: Functional regulatory roles of HNF1B in promoting cell proliferation, migration, invasion and fate decision of hepatocellular carcinoma
Functional regulatory roles of HNF1B in promoting cell proliferation, migration, invasion and fate decision of hepatocellular carcinoma Open
Our study elucidated the functional roles of HNF1B on regulating the biological behavior of HCC cells, suggesting that HNF1B could be an important molecular marker of HCC. This finding provides a potential molecular target for the diagnosi…
View article: Aspirin is associated with a reduction in mortality rate for patients with sepsis-induced coagulopathy: a retrospective cohort study
Aspirin is associated with a reduction in mortality rate for patients with sepsis-induced coagulopathy: a retrospective cohort study Open
Background This study aimed to examine whether aspirin reduces mortality in patients with sepsis-induced coagulopathy (SIC). Methods In this retrospective cohort study, 1,194 patients with SIC were identified from the Medical Information M…
View article: Evaluation of live surgery continuing education course in implantology for dentists: a retrospective cross-sectional survey
Evaluation of live surgery continuing education course in implantology for dentists: a retrospective cross-sectional survey Open
The live surgery teaching indicates high acceptance and satisfaction rates by dentists. We highly encourage more dental institutions to launch live surgery courses to achieve positive learning outcomes for dentists.
View article: Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities
Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities Open
Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction and inactivatio…
View article: Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment
Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment Open
Even after prolonged MMT, HUD individuals still show partial impairments in cognitive control and antisaccade performance. Previous relapse exacerbates cognitive control deficits through executive dysfunction in inhibition, cognitive flexi…
View article: Recombinant PRV Expressing GP3 and GP5 of PRRSV Provides Effective Protection Against Coinfection With PRV and PRRSV
Recombinant PRV Expressing GP3 and GP5 of PRRSV Provides Effective Protection Against Coinfection With PRV and PRRSV Open
Porcine Reproductive and Respiratory Syndrome (PRRS) and Pseudorabies (PR) are highly contagious diseases caused by Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and Pseudorabies virus (PRV). Due to the limited protective abi…
View article: Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis
Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis Open
Background and Aims: Reliable novel noninvasive biomarkers for the diagnosis of advanced liver fibrosis are urgently needed in clinical practice. We aimed to investigate the accuracy of plasma Follistatin-like protein 1 (FSTL-1) in the dia…
View article: A novel CAF-cancer cell crosstalk-related gene prognostic index based on machine learning: prognostic significance and prediction of therapeutic response in head and neck squamous cell carcinoma
A novel CAF-cancer cell crosstalk-related gene prognostic index based on machine learning: prognostic significance and prediction of therapeutic response in head and neck squamous cell carcinoma Open
Background Cancer-associated fibroblast (CAF)-cancer cell crosstalk (CCCT) plays an important role in tumor microenvironment shaping and immunotherapy response. Current prognostic indexes are insufficient to accurately assess immunotherapy…
View article: Endogenous Type I-C CRISPR-Cas system of Streptococcus equi subsp. zooepidemicus promotes biofilm formation and pathogenicity
Endogenous Type I-C CRISPR-Cas system of Streptococcus equi subsp. zooepidemicus promotes biofilm formation and pathogenicity Open
Streptococcus equi subsp. zooepidemicus (SEZ) is a significant zoonotic pathogen that causes septicemia, meningitis, and mastitis in domestic animals. Recent reports have highlighted high-mortality outbreaks among swine in the United State…
View article: Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity
Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity Open
Targeting NLRP3 inflammasome with inhibitors is a novel strategy for NLRP3-driven diseases. Herein, hit compound 5 possessing an attractive skeleton was identified from our in-house database of oridonin, and then a potential lead compound …
View article: Involvement of nucleus accumbens SERCA2b in methamphetamine‐induced conditioned place preference
Involvement of nucleus accumbens SERCA2b in methamphetamine‐induced conditioned place preference Open
Methamphetamine (METH) is a highly addictive psycho‐stimulant that induces addictive behaviour by stimulating increased dopamine release in the nucleus accumbens (NAc). The sarco/endoplasmic reticulum calcium ion transport ATPases (SERCA o…
View article: Application of novel probation teaching mode in implant dentistry curriculum for Chinese undergraduate students
Application of novel probation teaching mode in implant dentistry curriculum for Chinese undergraduate students Open
Background: Implant dentistry has developed rapidly due to elevated patient awareness and treatment expectations, resulting an increasing demand for educators to provide well-designed undergraduate oral implantology curriculum. However, no…
View article: Allergen-specific immunotherapy with Der p 1/2 mRNA vaccines alleviates house dust mite-induced allergic airway inflammation in a mouse model
Allergen-specific immunotherapy with Der p 1/2 mRNA vaccines alleviates house dust mite-induced allergic airway inflammation in a mouse model Open
Allergen-specific immunotherapy is the only treatment that alters the natural course of allergic diseases and provides long-term therapeutic effects. Current treatments are based on crude allergen extracts, which contain various complex co…
View article: Sex, executive function, and prospective memory regulate the chain-mediation pathway of alcohol use and impulsivity
Sex, executive function, and prospective memory regulate the chain-mediation pathway of alcohol use and impulsivity Open
Objective Evidence from previous studies indicates that impulsive behaviors are closely linked to alcohol use and misuse and that female drinkers are more impulsive than male drinkers. However, studies investigating the psychological mecha…
View article: Cognitive Control in Heroin Use Disorder Patients after Prolonged Methadone Maintenance Treatment
Cognitive Control in Heroin Use Disorder Patients after Prolonged Methadone Maintenance Treatment Open
Objective Relapse after detoxification remains a major challenge for addiction treatment worldwide. Although cognitive control impairment is common in heroin use disorder (HUD) patients and is considered a major cause of relapse, it remain…
View article: Effects of Online Game and Short Video Behavior on Academic Delay of Gratification - Mediating Effects of Anxiety, Depression and Retrospective Memory
Effects of Online Game and Short Video Behavior on Academic Delay of Gratification - Mediating Effects of Anxiety, Depression and Retrospective Memory Open
Excessive short videos behaviour may produce the same psychological problems and learning problems as online gaming disorder. Excessive short video and online gaming behaviors may affect ADOG performance through anxiety, depression, and pr…
View article: Design, Synthesis and Biological Evaluation of Novel Indanones Derivatives As Potent Acetylcholinesterase/Monoamine Oxidase B Inhibitors
Design, Synthesis and Biological Evaluation of Novel Indanones Derivatives As Potent Acetylcholinesterase/Monoamine Oxidase B Inhibitors Open
Aim: Based on a multitarget design strategy, a series of novel indanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Results: These compounds exhibited significant inhi…
View article: Small-Molecule Hydrophobic Tagging: A Promising Strategy of Druglike Technology for Targeted Protein Degradation
Small-Molecule Hydrophobic Tagging: A Promising Strategy of Druglike Technology for Targeted Protein Degradation Open
Targeted protein degradation (TPD) technologies have catalyzed a paradigm shift in therapeutic strategies and offer innovative avenues for drug design. Hydrophobic tags (HyTs) are bifunctional TPD molecules consisting of a ″lipophilic smal…
View article: Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study
Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study Open
Introduction Numerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rh…
View article: GPR35‐mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis
GPR35‐mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis Open
Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. Metabolites and their sensors play an important role in the communication between gut microbes and their host. Our previous study revealed that…
View article: Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model
Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model Open
Background Allergic airway disease (AAD) is a chronic disease characterized by airway inflammation, bronchoconstriction, and hyperresponsiveness. Although exogenous interleukin-10 (IL-10) alleviates allergic inflammation, it has a short ha…
View article: An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of Medical Students in China During the COVID-19 Pandemic: The Mediating Role of Social Support
An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of Medical Students in China During the COVID-19 Pandemic: The Mediating Role of Social Support Open
BACKGROUND The COVID-19 pandemic has caused varying degrees of psychological stress among medical students. This research explored the post-traumatic stress symptoms (PTSS) of medical students in China and their relationship with positive …
View article: Effects of short photoperiod on cashmere growth, hormone concentrations and hair follicle development-related gene expression in cashmere goats
Effects of short photoperiod on cashmere growth, hormone concentrations and hair follicle development-related gene expression in cashmere goats Open
Shanbei White Cashmere goat is a typical goat species, the growth of cashmere is affected by photoperiod. To further investigate the effects of short photoperiod treatment on cashmere growth, hormone concentrations and hair follicle develo…
View article: Mitochondrial calcium uniporter activates TFEB-driven autophagy to promote migration of breast cancer cells.
Mitochondrial calcium uniporter activates TFEB-driven autophagy to promote migration of breast cancer cells. Open
MCU activates TFEB-driven autophagy to promote BC cell metastasis and provides a potential novel therapeutic target for BC clinical intervention.