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View article: Case Report: Electrophysiological characteristics of the pelvic floor in spinal epidural lipomatosis
Case Report: Electrophysiological characteristics of the pelvic floor in spinal epidural lipomatosis Open
Electrophysiological examination of the pelvic floor plays a crucial role in localizing nerve damage in pelvic floor dysfunction (PFD). Spinal epidural lipomatosis (SEL) is a space-occupying disease of the spinal canal. SEL can cause spine…
View article: Gamma Analytical Modelling Evolution – I. The physical implications of deriving the stellar mass functions from <i>z</i> = 0 to <i>z</i> = 8
Gamma Analytical Modelling Evolution – I. The physical implications of deriving the stellar mass functions from <i>z</i> = 0 to <i>z</i> = 8 Open
The $\Gamma$ growth model is an effective parametrization employed across various scientific disciplines and scales to depict growth. It has been demonstrated that the cosmic star formation rate density (CSFRD) can also be described broadl…
View article: <i>BvCGT1</i>‐mediated differential distribution of flavonoid <i>C</i>‐glycosides contributes to plant's response to <scp>UV</scp>‐B stress
<i>BvCGT1</i>‐mediated differential distribution of flavonoid <i>C</i>‐glycosides contributes to plant's response to <span>UV</span>‐B stress Open
SUMMARY C ‐glycosides are a predominant class of flavonoids that demonstrate diverse medical properties and plant physiological functions. The chemical stability, structural diversity, and differential aboveground distribution of these com…
View article: Three types of enzymes complete the furanocoumarins core skeleton biosynthesis in Angelica sinensis
Three types of enzymes complete the furanocoumarins core skeleton biosynthesis in Angelica sinensis Open
Furanocoumarins (FCs) are widely distributed secondary metabolites found in higher plants, including Apiaceae, Rutaceae, Moraceae, and Fabaceae. They play a crucial role in the physiological functions of plants and are well-known for their…
View article: Quantum Computing at the Intersection of Engineering, Technology, Science, and Societal Need: Design of NGSS-aligned Quantum Drug Discovery Lessons for Middle School Students
Quantum Computing at the Intersection of Engineering, Technology, Science, and Societal Need: Design of NGSS-aligned Quantum Drug Discovery Lessons for Middle School Students Open
The emerging field of Quantum Computing (QC) is novel for most K12 educators. Fundamental understandings of QC rely on advanced mathematics and physics. Therefore, why is a middle or high school introduction to QC relevant or needed? In ou…
View article: Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1
Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1 Open
Silencing Rac1 and Prex1 could inhibit epithelial-mesenchymal transition, reduce cell viability and migration, and promote apoptosis in human gastric cancer cells.
View article: Energy-based generative models for target-specific drug discovery
Energy-based generative models for target-specific drug discovery Open
Drug targets are the main focus of drug discovery due to their key role in disease pathogenesis. Computational approaches are widely applied to drug development because of the increasing availability of biological molecular datasets. Popul…
View article: Random Relabeling for Efficient Machine Unlearning
Random Relabeling for Efficient Machine Unlearning Open
Learning algorithms and data are the driving forces for machine learning to bring about tremendous transformation of industrial intelligence. However, individuals' right to retract their personal data and relevant data privacy regulations …
View article: Retina-inspired narrowband perovskite sensor array for panchromatic imaging
Retina-inspired narrowband perovskite sensor array for panchromatic imaging Open
The retina is the essential part of the human visual system that receives light, converts it to neural signal, and transmits to brain for visual recognition. The red, green, and blue (R/G/B) cone retina cells are natural narrowband photode…
View article: Energy-based Generative Models for Target-specific Drug Discovery
Energy-based Generative Models for Target-specific Drug Discovery Open
Drug targets are the main focus of drug discovery due to their key role in disease pathogenesis. Computational approaches are widely applied to drug development because of the increasing availability of biological molecular datasets. Popul…
View article: Approximate Quantum Random Access Memory Architectures
Approximate Quantum Random Access Memory Architectures Open
Quantum supremacy in many applications using well-known quantum algorithms rely on availability of data in quantum format. Quantum Random Access Memory (QRAM), an equivalent of classical Random Access Memory (RAM), fulfills this requiremen…
View article: Error-Tolerant Mapping for Quantum Computing
Error-Tolerant Mapping for Quantum Computing Open
Quantum computers are built with fragile and noise/error-prone qubits. Some prominent errors include, decoherence/dephasing, gate error, readout error, leakage, and crosstalk. Furthermore, the qubits vary in terms of their quality. Some qu…
View article: Analysis of Power-Oriented Fault Injection Attacks on Spiking Neural Networks
Analysis of Power-Oriented Fault Injection Attacks on Spiking Neural Networks Open
Spiking Neural Networks (SNN) are quickly gaining traction as a viable alternative to Deep Neural Networks (DNN). In comparison to DNNs, SNNs are more computationally powerful and provide superior energy efficiency. SNNs, while exciting at…
View article: Retina-Inspired Narrowband Perovskite Sensor Array for Panchromatic Imaging
Retina-Inspired Narrowband Perovskite Sensor Array for Panchromatic Imaging Open
Retina, a thin layer of tissue, is the essential part of the human visual system that receives light, converts it to neural signal, and transmits it to the brain for visual recognition. The red, green, and blue (R/G/B) cone retina cells ar…
View article: Fault Injection Attacks in Spiking Neural Networks and Countermeasures
Fault Injection Attacks in Spiking Neural Networks and Countermeasures Open
Spiking Neural Networks (SNN) are fast emerging as an alternative option to Deep Neural Networks (DNN). They are computationally more powerful and provide higher energy-efficiency than DNNs. While exciting at first glance, SNNs contain sec…
View article: Scalable Variational Quantum Circuits for Autoencoder-based Drug Discovery
Scalable Variational Quantum Circuits for Autoencoder-based Drug Discovery Open
The de novo design of drug molecules is recognized as a time-consuming and costly process, and computational approaches have been applied in each stage of the drug discovery pipeline. Variational autoencoder is one of the computer-aided de…
View article: Performance modelling of direct contact membrane distillation using a hydrophobic/hydrophilic dual-layer membrane
Performance modelling of direct contact membrane distillation using a hydrophobic/hydrophilic dual-layer membrane Open
HFP-co-PVDF/N6 hydrophobic/hydrophilic dual-layer membrane was used to study desalination with direct contact membrane distillation (DCMD). A one-dimensional (1-D) model was proposed to predict the flux and thermal efficiency. Heat and mas…
View article: Drug Discovery Approaches using Quantum Machine Learning
Drug Discovery Approaches using Quantum Machine Learning Open
Traditional drug discovery pipeline takes several years and cost billions of dollars. Deep generative and predictive models are widely adopted to assist in drug development. Classical machines cannot efficiently produce atypical patterns o…
View article: Large-scale Quantum Approximate Optimization via Divide-and-Conquer
Large-scale Quantum Approximate Optimization via Divide-and-Conquer Open
Quantum Approximate Optimization Algorithm (QAOA) is a promising hybrid quantum-classical algorithm for solving combinatorial optimization problems. However, it cannot overcome qubit limitation for large-scale problems. Furthermore, the ex…
View article: Quantum Generative Models for Small Molecule Drug Discovery
Quantum Generative Models for Small Molecule Drug Discovery Open
Existing drug discovery pipelines take 5-10 years and cost billions of dollars. Computational approaches aim to sample from regions of the whole molecular and solid-state compounds called chemical space which could be on the order of 1060 …
View article: Quantum-soft QUBO Suppression for Accurate Object Detection
Quantum-soft QUBO Suppression for Accurate Object Detection Open
Non-maximum suppression (NMS) has been adopted by default for removing redundant object detections for decades. It eliminates false positives by only keeping the image M with highest detection score and images whose overlap ratio with M is…
View article: Engineering Burkholderia xenovorans LB400 BphA through Site-Directed Mutagenesis at Position 283
Engineering Burkholderia xenovorans LB400 BphA through Site-Directed Mutagenesis at Position 283 Open
The segment from positions 280 to 283 in BphAEs is located at the entrance of the catalytic pocket, and it shows variation in conformation. In previous works, results have suggested but never proved that residue Ser283 of BphAE LB400 might…