June Munro
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View article: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation Open
Nucleophosmin (NPM1), a nucleolar protein frequently mutated in hematopoietic malignancies, is overexpressed in several solid tumors with poorly understood functional roles. Here, we demonstrate that Npm1 is upregulated after APC loss in W…
View article: Hepatic zonation determines tumorigenic potential of mutant β-catenin
Hepatic zonation determines tumorigenic potential of mutant β-catenin Open
Oncogenic mutations in phenotypically normal tissue are common across adult organs 1,2 . This suggests that multiple events need to converge to drive tumorigenesis and that many processes such as tissue differentiation may protect against …
View article: The differential mechanisms of eIF4A1-mediated translational activation instructed by distinct RNA features
The differential mechanisms of eIF4A1-mediated translational activation instructed by distinct RNA features Open
All mRNAs require eukaryotic translation initiation factor (eIF) 4A1 for translation through its different functions: loading of the pre-initiation complex onto mRNAs and unwinding of RNA structure. eIF4A1 is the catalytic subunit of the c…
View article: Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors
Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors Open
Although protein synthesis inhibitors are being evaluated as anti-cancer agents, the dynamics of mRNA translation in early tumorigenesis are still poorly understood. We report that deletion of the mRNA-translation repressor, eIF4A2 in earl…
View article: eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers
eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers Open
Dysregulated translation is a hallmark of cancer. Targeting the translational machinery represents a therapeutic avenue which is being actively explored. eIF4A inhibitors target both eIF4A1, which promotes translation as part of the eIF4F …
View article: Optimisation of Sample Preparation from Primary Mouse Tissue to Maintain RNA Integrity for Methods Examining Translational Control
Optimisation of Sample Preparation from Primary Mouse Tissue to Maintain RNA Integrity for Methods Examining Translational Control Open
The protein output of different mRNAs can vary by two orders of magnitude; therefore, it is critical to understand the processes that control gene expression operating at the level of translation. Translatome-wide techniques, such as polys…
View article: Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control
Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control Open
Protein output of different mRNAs can vary by two orders of magnitude therefore it is critical to understand the processes that control gene expression that operate at the level of translation. Translatome-wide techniques such as polysome …
View article: Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth Open
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previo…
View article: Supplemental Figures and Tables from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Supplemental Figures and Tables from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Open
Supplemental Figure 1. Kinome selectivity profiles for BDP8900 and BDP9066. Supplemental Figure 2. Cancer cell line sensitivity to BDP8900 and BDP9066. Supplemental Figure 3. MRCKα phosphorylations compared with MRCKβ. Supplemental Figure …
View article: Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth Open
Supplemental Figure S1. No effect of ROCK inhibitors on the expression of ROCK1 or ROCK2. Supplemental Figure S2. ROCK1 and ROCK2 knockdown, dose-response relationships and IC50 determinations for AT13148 on cell morphology parameters. Sup…
View article: Supplemental Figures and Tables from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Supplemental Figures and Tables from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Open
Supplemental Figure 1. Kinome selectivity profiles for BDP8900 and BDP9066. Supplemental Figure 2. Cancer cell line sensitivity to BDP8900 and BDP9066. Supplemental Figure 3. MRCKα phosphorylations compared with MRCKβ. Supplemental Figure …
View article: Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth Open
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previo…
View article: Data from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Data from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Open
The myotonic dystrophy–related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin–myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The ab…
View article: Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth Open
Supplemental Figure S1. No effect of ROCK inhibitors on the expression of ROCK1 or ROCK2. Supplemental Figure S2. ROCK1 and ROCK2 knockdown, dose-response relationships and IC50 determinations for AT13148 on cell morphology parameters. Sup…
View article: Data from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Data from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Open
The myotonic dystrophy–related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin–myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The ab…
View article: Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Sprouty2 is a feedback regulator that controls the Ras/Raf/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent …
View article: Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Sprouty2 is a feedback regulator that controls the Ras/Raf/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent …
View article: Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation