Junfa Yang
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View article: SIRT1 in Liver Diseases: Mechanistic Insights and Therapeutic Prospects
SIRT1 in Liver Diseases: Mechanistic Insights and Therapeutic Prospects Open
Liver diseases present a formidable global health challenge and rank among the leading causes of morbidity and premature mortality worldwide. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent hist…
View article: Schottky barrier in pea-like Au@Bi2S3 nanoreactor enabling efficient photodynamic therapy of hepatocellular carcinoma
Schottky barrier in pea-like Au@Bi2S3 nanoreactor enabling efficient photodynamic therapy of hepatocellular carcinoma Open
View article: Organoid technologies in antitumor drug screening: past development, present applications, and future prospects
Organoid technologies in antitumor drug screening: past development, present applications, and future prospects Open
Tumors are one of the major diseases affecting human life and health with an increasing incidence worldwide. Drug therapy is the most commonly used treatment for tumors. Therefore, screening for antitumor drugs has always been a focus of t…
View article: The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications
The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications Open
View article: Graphical Abstract: Angew. Chem. Int. Ed. 17/2024
Graphical Abstract: Angew. Chem. Int. Ed. 17/2024 Open
In their Research Article (e202319677), Alessandro Porchetta et al. rationally designed PAM-engineered DNA hairpins as input-responsive activators of Cas12a.By utilizing the trans-cleavage activity of Cas12a as a signal transduction method…
View article: NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease
NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) is one of the common causes of chronic liver disease in the world. The problem of NAFLD had become increasingly prominent. However, its pathogenesis is still indistinct. As we all know, NAFLD begins…
View article: SOX9 promotes the invasion and migration of lung adenocarcinoma cells by activating the RAP1 signaling pathway
SOX9 promotes the invasion and migration of lung adenocarcinoma cells by activating the RAP1 signaling pathway Open
Objective SOX9 has been shown to be related to the metastasis of various cancers. Recently, it has been reported that SOX9 plays a regulatory role in lung adenocarcinoma (LUAD) cell metastasis, but the specific mechanism remains to be expl…
View article: Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression
Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression Open
Non-thermal plasma (NTP) is thought to have a cytotoxic effect on tumor cells. Although its application in cancer therapy has shown considerable promise, the current understanding of its mechanism of action and cellular responses remains i…
View article: Role of microRNA alternation in the pathogenesis of gouty arthritis
Role of microRNA alternation in the pathogenesis of gouty arthritis Open
Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3’…
View article: MDP Induces the Senescence of Activated Hepatic Stellate Cells Through Regulating Ago2/miR-708/ZEB1/p53 Pathway
MDP Induces the Senescence of Activated Hepatic Stellate Cells Through Regulating Ago2/miR-708/ZEB1/p53 Pathway Open
Background Extracellular matrix (ECM) is mainly derived from activated hepatic stellate cells (HSC), and its excessive deposition is one of the characteristics of liver fibrosis. Accumulating evidence indicated that the senescence of activ…
View article: A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoV
A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoV Open
The outbreak of coronavirus disease 2019 (COVID-19) has been spreading rapidly in China and the Chinese government took a series of policies to control the epidemic. Studies found that severe COVID-19 is characterized by pneumonia, lymphop…
View article: Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1 Open
View article: Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression
Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression Open
Puerarin, an isoflavone component extracted from herb radix puerariae, is widely used in China in the treatment of immune diseases and inflammation. Previous studies have demonstrated that puerarin prevented acute lung injury by regulating…
View article: Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy
Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy Open
View article: The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19
The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19 Open
Inflammasomes are large multimolecular complexes best recognized because of their ability to control activation of caspase-1, which in turn regulates the maturation of interleukin-18 (IL-18) and interleukin-1 β (IL-1β). IL-1β was originall…
View article: The Prognostic Value and Mechanisms of TMEM16A in Human Cancer
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer Open
As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers. Mechanically, TMEM16A participates in …
View article: ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway
ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway Open
View article: The Role of IL-35 in the Pathophysiological Processes of Liver Disease
The Role of IL-35 in the Pathophysiological Processes of Liver Disease Open
It is known that liver diseases have several characteristics of massive lipid accumulation and lipid metabolic disorder, and are divided into liver inflammation, liver fibrosis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC) in p…
View article: Relevance Function of Linc-ROR in the Pathogenesis of Cancer
Relevance Function of Linc-ROR in the Pathogenesis of Cancer Open
Long non-coding RNAs (lncRNAs) are the key components of non-coding RNAs (ncRNAs) with a length of 200 nucleotides. They are transcribed from the so-called "dark matter" of the genome. Increasing evidence have shown that lncRNAs play an im…
View article: MicroRNA‐708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88
MicroRNA‐708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88 Open
Transmembrane protein 88 (TMEM88) is a potential 2‐transmembrane‐type protein that interacts with the PDZ domain of Dishevelled‐1 (DVL‐1), a crucial component of Wnt signalling pathway through its C‐terminal Val‐Trp‐Val (VWV) motif in Xeno…
View article: ZEB1 regulates the activation of hepatic stellate cells through Wnt/β-catenin signaling pathway
ZEB1 regulates the activation of hepatic stellate cells through Wnt/β-catenin signaling pathway Open
Zinc finger E-box binding homeobox 1 (ZEB1) (previously known as TCF8), a transcriptional repressor, is a member of the zinc-finger family of proteins. Numerous studies have demonstrated that abnormal expression of ZEB1 in many types of li…
View article: Extracellular Vesicles as Carriers of Non-coding RNAs in Liver Diseases
Extracellular Vesicles as Carriers of Non-coding RNAs in Liver Diseases Open
Extracellular vesicles (EVs) are small membranous vesicles secreted from normal, diseased, and transformed cells in vitro and in vivo. EVs have been found to play a critical role in cell-to-cell communication by transferring …
View article: MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway
MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway Open
During the liver fibrosis recovery stage tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can effectively induce apoptosis of activated hepatic stellate cells (HSCs). Normal hepatic stellate cells are resistant to TRAIL cyto…