Explanipedia

C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling Open

Yufeng Qiao, Zhenhua Wu, Peng Wang, Yiliang Jin, Furong Bai , et al. · 2025

Protein arginine methyltransferase 5 (PRMT5) complexes with methylosome protein 50 (MEP50) play crucial roles in tumor progress. However, the regulatory mechanism of governing the PRMT5-MEP50 hetero-octameric complex remains unclear. Here,…

Development and validation of nomogram for predicting pathological complete response to neoadjuvant chemotherapy and immunotherapy for locally advanced gastric cancer: a multicenter real-world study in China Open

Hao Cui, Rui Li, Liqiang Song, Yongpu Yang, Zhen Yuan , et al. · 2025

Background The combination of neoadjuvant chemotherapy and immunotherapy (NICT) brings a higher proportion of pathological complete response (pCR) compared with neoadjuvant chemotherapy for locally advanced gastric cancer (LAGC). Here we c…

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression Open

Haiyang Liu, Jing Lin, Yixin Li, Jinxing Zhou, Xiaohui Cui , et al. · 2025

TP53 inactivation in human cancers often results from MDM2/MDMX overexpression, yet therapeutic targeting remains challenging owing to incomplete mechanistic understanding. Lipid droplet (LD) enrichment is identified as a key trigger for M…

Pan‐immune‐inflammation value predicts immunotherapy response and reflects local antitumor immune response in rectal cancer Open

Qianyu Wang, Wentao Zhong, Yi Xiao, Guole Lin, Junyang Lu , et al. · 2024

The pan‐immune‐inflammation value reflects the systemic inflammatory response, and tumor‐infiltrating lymphocytes indicate a local immune response in rectal cancer. However, the association between systemic inflammatory response, as indica…

Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location Open

Qianyu Wang, Wentao Zhong, Yi Xiao, Guole Lin, Junyang Lu , et al. · 2024

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers (LCC) and right-sided colon cancers (RCC). Pan-immune-inflammation value (PIV) is a systemic immune response marker that can predict t…

Analysis of risk factors for liver metastasis in patients with gastric cancer and construction of prediction model: A multicenter study Open

Heng Yu, Hang Jiang, Xiaofeng Lu, Chunhua Bai, Peng Song , et al. · 2024

By innovatively introducing a new tumor location classification method, systemic inflammatory response indicators such as NLR and PLR, and nutritional index OPNI, the risk factors of gastric cancer liver metastasis were determined and a pr…

Chemoradiotherapy plus tislelizumab for mismatch repair proficient rectal cancer with supraclavicular lymph node metastasis: A case report Open

Wentao Zhong, Yuan Lv, Qianyu Wang, Ran An, Gang Chen , et al. · 2024

BACKGROUND According to the latest report, colorectal cancer is still one of the most prevalent cancers, with the third highest incidence and mortality worldwide. Treatment of advanced rectal cancer with distant metastases is usually unsat…

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer Open

Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan , et al. · 2024

Neutrophil Extracellular Trap is Surrogate Biomarker for Prognosis and Response to Neoadjuvant Therapy in Locally Advanced Rectal Cancer Open

Wentao Zhong, Qianyu Wang, Xiaofei Shen, Yuan Lv, Liang Sun , et al. · 2023

NET was an independent prognostic factor in LARC that were associated with patients' survival, and NET density in pretreatment biopsies was an independent predictive biomarker of response to neoadjuvant therapy. This biomarker may be helpf…

Editorial: The role of immune checkpoints in gastrointestinal diseases Open

Xiaofei Shen, Junfeng Du · 2023

EDITORIAL article Front. Physiol., 31 July 2023Sec. Gastrointestinal Sciences Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1251966

Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis Open

Shanshan Chao, Fei Zhang, Huiwen Yan, Liuyang Wang, Liwen Zhang , et al. · 2023

The emerging role of neutrophil extracellular traps in cancer: from lab to ward Open

Wentao Zhong, Qianyu Wang, Xiaofei Shen, Junfeng Du · 2023

Neutrophil extracellular traps (NETs) are web-like structures derived from neutrophils, which typically consist of DNA, released from the nucleus or mitochondria, and decorated with histones and granule proteins. They are well known as an …

Targeting myeloid-derived suppressor cells in tumor immunotherapy: Current, future and beyond Open

Yang Zhao, Junfeng Du, Xiaofei Shen · 2023

Myeloid-derived suppressor cells (MDSCs) are one of the major negative regulators in tumor microenvironment (TME) due to their potent immunosuppressive capacity. MDSCs are the products of myeloid progenitor abnormal differentiation in bone…

Peritumoral tertiary lymphoid structure and tumor stroma percentage predict the prognosis of patients with non-metastatic colorectal cancer Open

Qianyu Wang, Xiaofei Shen, Ran An, Junchao Bai, Junhua Dong , et al. · 2022

Background Tertiary lymphoid structures (TLSs) are crucial in promoting and maintaining positive anti-tumor immune responses. The tumor stroma has a powerful immunosuppressive function that could exclude tumor-infiltrating lymphocytes from…

Drug Resistance in Colorectal Cancer: From Mechanism to Clinic Open

Qianyu Wang, Xiaofei Shen, Gang Chen, Junfeng Du · 2022

Colorectal cancer (CRC) is one of the leading causes of death worldwide. The 5-year survival rate is 90% for patients with early CRC, 70% for patients with locally advanced CRC, and 15% for patients with metastatic CRC (mCRC). In fact, mos…

Simultaneous quantification of 18 bioactive constituents in Ziziphus jujuba fruits by HPLC coupled with a chemometric method Open

Tianyi Wang, Sen Guo, Xiameng Ren, Junfeng Du, Lu Bai , et al. · 2022

The fruit of Ziziphus jujuba Mill., known as Hongzao (or Hong-Zao) in Chinese and cultivated in China for more than 4000 years, has shown to have hepatoprotective property. In previous study, we have isolated and identified 27 known compou…

<i>Fusobacterium nucleatum</i> Promotes Colorectal Cancer Cell to Acquire Stem Cell‐Like Features by Manipulating Lipid Droplet‐Mediated Numb Degradation Open

Haiyang Liu, Junfeng Du, Shanshan Chao, Shuoguo Li, Huiyun Cai , et al. · 2022

Fusobacterium nucleatum is a critical microbe that contributes to colorectal cancer progression and chemoresistance. However, whether and how F. nucleatum regulates colorectal cancer stem‐like cells (CCSCs) remains unknown. Here, the autho…

Targeting Neutrophils in Sepsis: From Mechanism to Translation Open

Xiaofei Shen, Ke Cao, Yang Zhao, Junfeng Du · 2021

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of…

Creatine promotes cancer metastasis through activation of Smad2/3 Open

Liwen Zhang, Zijing Zhu, Huiwen Yan, Wen Wang, Zhenhua Wu , et al. · 2021

Circulating Tumor DNA Detection Using Digital Polymerase Chain Reaction—Promising But Needs Improvement Open

Junfeng Du, Wenxian Guan, Xiaofei Shen · 2021

CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure Open

Zhenhua Wu, Jingyu Liu, Gang Chen, Junfeng Du, Huiyun Cai , et al. · 2021

Obesity and its related complications pose an increasing threat to human health; however, targetable obesity‐related membrane receptors are not yet elucidated. Here, the membrane receptor CD146 is demonstrated to play an essential role in …

Should peritoneal tears be repaired during retroperitoneal laparoscopic radical nephrectomy? Open

Jingfei Teng, Junfeng Du, Feng Gao, Yawei Guan, Xing Ai · 2020

To the Editor: Laparoscopic radical nephrectomy (LRN) is the standard of care for patients with T2 tumors and localized masses not treatable by partial nephrectomy according to the European Association of Urology Guidelines on renal cell c…

Preliminary results on anal cancer by applying intensity modulated radiotherapy and synchronous capecitabine chemotherapy simultaneously Open

Weidong Xu, Huayong Jiang, Junmao Gao, Junfeng Du, Gang Chen , et al. · 2020

SIB-IMRT with concomitant capecitabine 625 mg/m² b.i.d. on irradiation days resulted in an acceptable safety profile, and proved to be a tolerable and effective treatment regimen for locally advanced anal cancer. However, a larg…

The value of chemotherapy in stage II colon cancer: Much less than we thought Open

Lidong Wu, Jianfei Fu, Wei Fu, Junfeng Du, Lin Wang · 2018

Background: The use of adjuvant chemotherapy in stage II colon cancer patients remains controversial. We sought to evaluate the real effectiveness of chemotherapy on stage II colon cancer as well as select suitable patients for additional …

DISTURBANCE OF AN APOPTOSIS OF NEUTROPHILS AT A SEPSIS Open

Xiaofei Shen, Wenxian Guan, Junfeng Du, L. V. Puzyryova · 2018

The sepsis represents life-endangering disturbances of functions of the internals caused by a dizregulyation of a macroorganism to the infectious agent and is difficult interaction of pro-inflammatory and antiinflammatory processes that no…

Dexamethasone-Induced Myeloid-Derived Suppressor Cells Prolong Allo Cardiac Graft Survival through iNOS- and Glucocorticoid Receptor-Dependent Mechanism Open

Yang Zhao, Xiaofei Shen, Ke Cao, Jie Ding, Xing Kang , et al. · 2018

How to induce immune tolerance without long-term need for immunosuppressive drugs has always been a central problem in solid organ transplantation. Modulating immunoregulatory cells represents a potential target to resolve this problem. My…

A retrospective study of 34ï¿½patients with unicentric and multicentric Castleman's disease: Experience from a single institution Open

Jinpeng Jiang, Xiaofei Shen, Junfeng Du, Wenxian Guan · 2017

The aim of the present study was to share the experience of a single institute in the diagnosis, use of accessory examinations and treatment strategies of Castleman's disease (CD). The present study analyzed 34 patients (13 males and 21 fe…

Wip1 Deficiency Promotes Neutrophil Recruitment to the Infection Site and Improves Sepsis Outcome Open

Xiaofei Shen, Yang Zhao, Ke Cao, Wenxian Guan, Xue Li , et al. · 2017

Sepsis is defined as an uncontrolled host response to infection, and no specific therapy or drugs have been used in clinical trials currently. Discovering new therapeutic targets for sepsis treatment has always been a central problem in th…

Neutrophil dysregulation during sepsis: an overview and update Open

Xiaofei Shen, Ke Cao, Jinpeng Jiang, Wenxian Guan, Junfeng Du · 2017

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical rol…

Phosphatase Wip1 in Immunity: An Overview and Update Open

Xiaofei Shen, Yang Zhao, Jinpeng Jiang, Wenxian Guan, Junfeng Du · 2017

Wild-type p53-induced phosphatase 1 (Wip1) is a newly identified serine/threonine phosphatase, which belongs to the PP2C family. Due to its involvement in stress-induced networks and overexpression in human tumors, primary studies have mai…

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