Junfeng Huang
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View article: Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes
Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes Open
Importance Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message–based intervention strategies could address this gap but lack evidence of benefit on multiple …
View article: Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis
Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis Open
These findings suggest that BSC-EVs represent a promising therapeutic strategy for BTS by inhibiting fibroblast activation and promoting ECM remodeling via the miR-30a-5p/FAP axis, offering a novel advancement beyond current treatment appr…
View article: KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression Open
Histone lactylation is a novel epigenetic modification derived from lactate, but its role and mechanism in KRAS mutant colorectal cancer (CRC) progression remains to be fully elucidated. In this study, we first showed that mutant KRAS incr…
View article: ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7 Open
Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (…
View article: Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts
Airway basal stem cell-derived extracellular vesicles modulate proliferation, migration and collagen deposition of fibroblasts Open
View article: Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes
Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes Open
View article: Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells
Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells Open
Background Tumour immune macroenvironment is comprised of tumour and surrounding organs responding to tumourigenesis and immunotherapy. The lack of comprehensive analytical methods hinders its application for prediction of survival and tre…
View article: Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway Open
Our results suggest that exercise can induce the production of Lac-Phe, which plays a preventive role against dextran sulfate sodium-induced colitis in mice. Lac-Phe mitigates colitis through inhibition of the polarization of M1 macrophage…
View article: CTL-SSI-LAMP Platform for Rapid On-site Detection of Surgical Site Infection Post-Liver-Surgery in Abdominal Drainage Fluid Samples
CTL-SSI-LAMP Platform for Rapid On-site Detection of Surgical Site Infection Post-Liver-Surgery in Abdominal Drainage Fluid Samples Open
View article: Airway Basal Stem Cell-Derived Extracellular Vesicles Drive Ecm Remodeling and Suppress Fibroblasts Activation Via the Mir-30a-5p/Fap Axis in Benign Tracheal Stenosis
Airway Basal Stem Cell-Derived Extracellular Vesicles Drive Ecm Remodeling and Suppress Fibroblasts Activation Via the Mir-30a-5p/Fap Axis in Benign Tracheal Stenosis Open
View article: Detection of urine circulating tumor DNA using droplet digital PCR for predicting hepatocellular carcinoma recurrence
Detection of urine circulating tumor DNA using droplet digital PCR for predicting hepatocellular carcinoma recurrence Open
Aim: This study aims to evaluate the feasibility of examining circulating tumor DNA (ctDNA) in urine samples from hepatocellular carcinoma (HCC) patients by droplet digital PCR (ddPCR) and to assess its value in predicting HCC recurrence a…
View article: Impact of solid fuel use on asthma prognosis and consistent peak expiratory flow changes: Evidence from China
Impact of solid fuel use on asthma prognosis and consistent peak expiratory flow changes: Evidence from China Open
The research provided insights into the harmful effects of solid fuel dependence on asthma risk and outcomes, contributing novel evidence supporting this link. The results emphasize the necessity of curtailing solid fuel use to diminish po…
View article: Perturbational Decomposition Analysis for Quantum Ising Model with Weak Transverse Fields
Perturbational Decomposition Analysis for Quantum Ising Model with Weak Transverse Fields Open
This work presents a perturbational decomposition method for simulating quantum evolution under the one-dimensional Ising model with both longitudinal and transverse fields. By treating the transverse field terms as perturbations in the ex…
View article: Perturbational Decomposition Analysis for Quantum Ising Model with Weak Transverse Fields
Perturbational Decomposition Analysis for Quantum Ising Model with Weak Transverse Fields Open
This work presented a perturbational decomposition method for simulating quantum evolution under the one-dimensional Ising model with both longitudinal and transverse fields. By treating the transverse field terms as perturbations in the e…
View article: <scp>MTHFD1</scp> Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the <scp>PI3K</scp>‐<scp>AKT</scp>–<scp>mTOR</scp> Signaling Pathway
<span>MTHFD1</span> Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the <span>PI3K</span>‐<span>AKT</span>–<span>mTOR</span> Signaling Pathway Open
Objectives Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is the enzyme with the activities of methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetase. Our aim was to elu…
View article: SPI1-KLF1/LYL1 axis regulates lineage commitment during endothelial-to-hematopoietic transition from human pluripotent stem cells
SPI1-KLF1/LYL1 axis regulates lineage commitment during endothelial-to-hematopoietic transition from human pluripotent stem cells Open
PU.1 (SPI1) is pivotal in hematopoiesis, yet its role in human endothelial-to-hematopoietic transition (EHT) remains unclear. Comparing human in vivo and in vitro EHT transcriptomes revealed SPI1's regulatory ro…
View article: OGA mutant aberrantly hydrolyzes O-GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy
OGA mutant aberrantly hydrolyzes O-GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy Open
O-GlcNAcase (OGA) is the only human enzyme that catalyzes the hydrolysis (deglycosylation) of O-linked beta- N -acetylglucosaminylation (O-GlcNAcylation) from numerous protein substrates. OGA has broad implications in many challenging dise…
View article: Cytochemical localization and synthesis mechanism of the glucomannan in pseudobulbs of <i>Bletilla striata</i> Reichb. f
Cytochemical localization and synthesis mechanism of the glucomannan in pseudobulbs of <i>Bletilla striata</i> Reichb. f Open
The dried pseudobulbs of Bletilla striata, an important traditional Chinese medicine named BaiJi, have an extraordinary polysaccharide content and excellent prospects for medicinal effects. However, the distribution and molecular mechanism…
View article: <scp><i>NEAT1</i></scp> repression by <scp>MED12</scp> creates chemosensitivity in p53 wild‐type breast cancer cells
<span><i>NEAT1</i></span> repression by <span>MED12</span> creates chemosensitivity in p53 wild‐type breast cancer cells Open
Breast cancer is often treated with chemotherapy. However, the development of chemoresistance results in treatment failure. Long non‐coding RNA nuclear paraspeckle assembly transcript 1 ( NEAT1 ) has been shown to contribute to chemoresist…
View article: NEAT1 repression by MED12 creates chemosensitivity in p53 wild‐type breast cancer cells
NEAT1 repression by MED12 creates chemosensitivity in p53 wild‐type breast cancer cells Open
Breast cancer is often treated with chemotherapy. However, the development of chemoresistance results in treatment failure. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been shown to contribute to chemoresistan…
View article: 11-Plex DiLeu Isobaric Labeling Enables Quantitative Assessment of Brain Region Protein Association Networks Impacted by the Gut Microbiome
11-Plex DiLeu Isobaric Labeling Enables Quantitative Assessment of Brain Region Protein Association Networks Impacted by the Gut Microbiome Open
Gut microbiota can regulate host brain functions and influence various physiological and pathological processes through the brain-gut axis. To systematically elucidate the intervention of different gut environments on different brain regio…
View article: Developmental Patterns and Gender Differences of Vocal Production in Marmoset Monkeys
Developmental Patterns and Gender Differences of Vocal Production in Marmoset Monkeys Open
View article: Imaging features and clinical value of 18F-FDG PET/CT for predicting airway involvement in patients with relapsing polychondritis
Imaging features and clinical value of 18F-FDG PET/CT for predicting airway involvement in patients with relapsing polychondritis Open
View article: Cotton Ti-IMAC: Developing Phosphorylated Cotton as a Novel Platform for Phosphopeptide Enrichment
Cotton Ti-IMAC: Developing Phosphorylated Cotton as a Novel Platform for Phosphopeptide Enrichment Open
Protein phosphorylation is an important post-translational modification (PTM), which is involved in many important cellular functions. Understanding protein phosphorylation at the molecular level is critical to deciphering its relevant bio…
View article: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex Open
In Saccharomyces cerevisiae , cryptic transcription at the coding region is prevented by the activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the transcribing RNA polymerase II (RNAPII) to deacetylate and stab…
View article: Extremely stable Li-metal battery enabled by piezoelectric polyacrylonitrile quasi-solid-state electrolytes
Extremely stable Li-metal battery enabled by piezoelectric polyacrylonitrile quasi-solid-state electrolytes Open
Polymer solid-state electrolytes (PSSEs) are promising for solving the safety problem of Lithium (Li) metal batteries (LMBs). However, PSSEs with low modulus in nature are prone to be penetrated by lithium dendrites, resulting in short cir…
View article: ATP-Coated Dual-Functionalized Titanium(IV) IMAC Material for Simultaneous Enrichment and Separation of Glycopeptides and Phosphopeptides
ATP-Coated Dual-Functionalized Titanium(IV) IMAC Material for Simultaneous Enrichment and Separation of Glycopeptides and Phosphopeptides Open
Protein glycosylation and phosphorylation are two of the most common post-translational modifications (PTMs), which play an important role in many biological processes. However, low abundance and poor ionization efficiency of phosphopeptid…
View article: Bioinspired MXene‐Based Piezoresistive Sensor with Two‐stage Enhancement for Motion Capture (Adv. Funct. Mater. 18/2023)
Bioinspired MXene‐Based Piezoresistive Sensor with Two‐stage Enhancement for Motion Capture (Adv. Funct. Mater. 18/2023) Open
Bioinspired Intermittent Designs In article number 2214503, Weiqing Yang, Weili Deng, and co-workers present a strategically designed villus-inspired intermittent architecture that can enhance the piezoresistive performance through a laser…
View article: Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53
Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53 Open
O-GlcNAcase (OGA) is the sole enzyme that hydrolyzes O-GlcNAcylation from thousands of proteins and is dysregulated in many diseases including cancer. However, the substrate recognition and pathogenic mechanisms of OGA remain largely unkno…
View article: Simultaneously Addressing Self-Stacking and Oxidative Degradation Issues of Ti3c2tx Mxene Through Biothermochemistry Induced 3d Crosslinking
Simultaneously Addressing Self-Stacking and Oxidative Degradation Issues of Ti3c2tx Mxene Through Biothermochemistry Induced 3d Crosslinking Open