Zhi‐Xiang Yu
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View article: Ring-Opening Polymerization of Unprotected Hydroxyproline <i>N</i> -Carboxyanhydride for the Facile Synthesis of Linear and Branched Poly- <scp>l</scp> -hydroxyproline
Ring-Opening Polymerization of Unprotected Hydroxyproline <i>N</i> -Carboxyanhydride for the Facile Synthesis of Linear and Branched Poly- <span>l</span> -hydroxyproline Open
View article: gem-DifluoroVinylcyclopropane (DF-VCP) Rearrangement to Cyclopentenones Catalyzed by Rhodium: Reaction Development and Mechanistic Study
gem-DifluoroVinylcyclopropane (DF-VCP) Rearrangement to Cyclopentenones Catalyzed by Rhodium: Reaction Development and Mechanistic Study Open
A serendipitously discovered Rh-catalyzed gemdifluorovinylcyclopropane (DF-VCP) rearrangement (also named as 1,3-sigma migratory ring expansion) has been developed to synthesize synthetically important 2- cyclopentenones, usually accessed …
View article: Escalating risks of anomalously hot–dry growing seasons in arid Northwest China under human influence
Escalating risks of anomalously hot–dry growing seasons in arid Northwest China under human influence Open
View article: Rhodium‐Catalyzed 1,5‐Sigma Migratory Ring Expansion of <i>gem</i> ‐Difluorodienyl Cyclopropanes and Cyclobutanes
Rhodium‐Catalyzed 1,5‐Sigma Migratory Ring Expansion of <i>gem</i> ‐Difluorodienyl Cyclopropanes and Cyclobutanes Open
Rhodium‐catalyzed 1,5‐sigma migratory ring expansion (SMRE) of common dieneylcyclopropanes (DECPs) and dieneylcyclobutanes (DECBs) fails. But replacing the terminal CH 2 group with CF 2 group for both DECPs and DECBs, the resulting substra…
View article: Nickel-Catalyzed [4 + 4] Cycloaddition of Diene-Vinylcyclobutanones
Nickel-Catalyzed [4 + 4] Cycloaddition of Diene-Vinylcyclobutanones Open
Reported here is a Ni(0)-catalyzed [4 + 4] cycloaddition of diene-vinylcyclobutanones to access trans-5/8 bicyclic structure with a bridgehead quaternary carbon center, which is found in natural products but cannot be accessed by existing …
View article: Enantioselective Assembly of Fully Substituted α‐Amino Allenoates Through a Mannich Addition and Stepwise [3,3]‐σ Rearrangement Sequence
Enantioselective Assembly of Fully Substituted α‐Amino Allenoates Through a Mannich Addition and Stepwise [3,3]‐σ Rearrangement Sequence Open
Chiral fully‐substituted allenes are synthetically significant and pivotal building blocks that can engage in diverse transformations toward a variety of bioactive molecules. The enantioselective assembly of these skeletons using readily a…
View article: Rhodium-Catalyzed [5 + 1 + 2] Cycloaddition of Yne-3-Acyloxy-1,4-Enynes (YACEs) and Carbon Monoxide: Reaction Development and Mechanism
Rhodium-Catalyzed [5 + 1 + 2] Cycloaddition of Yne-3-Acyloxy-1,4-Enynes (YACEs) and Carbon Monoxide: Reaction Development and Mechanism Open
Developing new reaction to synthesize challenging eight-membered carbocycles is a research frontier of organic synthesis. Reported here is the development of the first Rh-catalyzed [5 + 1 + 2] cycloaddition of yne-3-acyloxy-1,4-enyne (Yne-…
View article: C–H functionalization of 2-alkyl tryptamines: direct assembly of azepino[4,5- <i>b</i> ]indoles and total synthesis of ngouniensines
C–H functionalization of 2-alkyl tryptamines: direct assembly of azepino[4,5- <i>b</i> ]indoles and total synthesis of ngouniensines Open
The concise total synthesis of ngouniensines is reported, in which 2-Me-tryptamine undergoes sequential C–H functionalization with different aldehydes to afford the azepino[4,5- b ]indole core and an exocyclic conjugated alkene, respective…
View article: Progress in Transition-Metal-Catalyzed Carbonylative Cycloadditions Using Carbon Monoxide
Progress in Transition-Metal-Catalyzed Carbonylative Cycloadditions Using Carbon Monoxide Open
Transition-metal-catalyzed cycloadditions have been evolved as important and efficient methods to construct cyclic molecules.Among them, transition-metal-catalyzed cycloadditions using carbon monoxide (CO) gas as the 1C synthon provide the…
View article: Natural Products Inspired [3 + 2] Cycloaddition Enables Efficient Syntheses of Lignans
Natural Products Inspired [3 + 2] Cycloaddition Enables Efficient Syntheses of Lignans Open
Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed [3 + 2] cycloaddition of α-hydroxyketone and β-keto enol ethers, affording chiral tetrahydrofuran acetals in a highly diastereoselective manner …
View article: CCDC 2249373: Experimental Crystal Structure Determination
CCDC 2249373: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110463: Experimental Crystal Structure Determination
CCDC 2110463: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2265899: Experimental Crystal Structure Determination
CCDC 2265899: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2246883: Experimental Crystal Structure Determination
CCDC 2246883: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2083438: Experimental Crystal Structure Determination
CCDC 2083438: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Catalytic 4-exo-dig carbocyclization for the construction of furan-fused cyclobutanones and synthetic applications
Catalytic 4-exo-dig carbocyclization for the construction of furan-fused cyclobutanones and synthetic applications Open
Cyclobutanone is a strained motif with broad applications, while direct assembly of the aromatic ring fused cyclobutanones beyond benzocyclobutenone (BCB) skeletons remains challenging. Herein, we report a Rh-catalyzed formal [3+2] annulat…
View article: 1,5‐X Insertions of Free Alkylidene Carbenes: A Theoretical Study
1,5‐X Insertions of Free Alkylidene Carbenes: A Theoretical Study Open
1,5‐X insertions of alkylidene carbenes are powerful methods to construct five‐membered carbocycles and heterocycles, but the mechanisms of these 1,5‐X insertions of alkylidene carbenes remain unclear (concerted or stepwise?). Here we disc…
View article: CCDC 2071102: Experimental Crystal Structure Determination
CCDC 2071102: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160531: Experimental Crystal Structure Determination
CCDC 2160531: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2165574: Experimental Crystal Structure Determination
CCDC 2165574: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2156664: Experimental Crystal Structure Determination
CCDC 2156664: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Antrodiellin B/hypnophilin/coriolin and strained 5/5/5 and 5/6/4 skeletons via [5+2+1]/epoxidation/transannular radical cyclization
Antrodiellin B/hypnophilin/coriolin and strained 5/5/5 and 5/6/4 skeletons via [5+2+1]/epoxidation/transannular radical cyclization Open
Many natural products contain compact cis-anti-cis-configurated 5/5/5 and 5/6/4 tricycles, and efficient access to these molecules is posing many hurdles to the synthetic community. Accessing molecules with more strained trans-anti-cis-con…
View article: Metalla‐Claisen Rearrangement in Gold‐Catalyzed [4+2] Reaction: A New Elementary Reaction Suggested for Future Reaction Design
Metalla‐Claisen Rearrangement in Gold‐Catalyzed [4+2] Reaction: A New Elementary Reaction Suggested for Future Reaction Design Open
We report here computational evidence for a metalla‐Claisen rearrangement (MCR) in the case of gold‐catalyzed [4+2] cycloaddition reaction of yne‐dienes. The [4+2] reaction starts from exo cyclopropanation, followed by MCR and reductive el…
View article: Syntheses of (+)-Antrodiellin B, (−)-Hypnophilin and (−)-Coriolin and Strained 5/5/5 and 5/6/4 Skeletons via [5+2+1]/Epoxidation/Transannular Radical Cyclization
Syntheses of (+)-Antrodiellin B, (−)-Hypnophilin and (−)-Coriolin and Strained 5/5/5 and 5/6/4 Skeletons via [5+2+1]/Epoxidation/Transannular Radical Cyclization Open
Nature produces many molecules (so-called natural products) containing compact scaffolds such as cis-anti-cis-configurated 5/5/5 and 5/6/4 tricycles. But other molecules with more strained structures, such as trans-anti-cis-configurated 5/…
View article: Selective Enyne Ring-Closing Metathesis with Main Group Metal Catalysts
Selective Enyne Ring-Closing Metathesis with Main Group Metal Catalysts Open
Ring-closing metathesis (RCM) represents an ideal and atom-economical way to construct cyclic compounds. The precedented reaction systems for endo-selective enyne RCM mainly rely on precious transition metal carbene complexes or activated …
View article: Strain-Release Controlled [4+2+1] Reaction of Cyclopropyl-Capped Diene-Ynes/Diene-enes and CO Catalyzed by Rhodium
Strain-Release Controlled [4+2+1] Reaction of Cyclopropyl-Capped Diene-Ynes/Diene-enes and CO Catalyzed by Rhodium Open
Achieving transition metal-catalyzed reactions of diene-enes/diene-ynes and carbon monoxide (CO) to deliver [4+2+1] cycloadducts, rather than the kinetically favored [2+2+1] products, is challenging. Here, we report that this can be solved…
View article: Strain-Release Controlled [4+2+1] Reaction of Cyclopropyl-Capped Diene-Ynes/Diene-enes and CO Catalyzed by Rhodium
Strain-Release Controlled [4+2+1] Reaction of Cyclopropyl-Capped Diene-Ynes/Diene-enes and CO Catalyzed by Rhodium Open
Achieving transition metal-catalyzed reactions of diene-enes/diene-ynes and carbon monoxide (CO) to deliver [4+2+1] cycloadducts, rather than the kinetically favored [2+2+1] products, is challenging. Here, we report that this can be solved…
View article: Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury
Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury Open
Background: Circular RNAs (circRNAs), which have broad posttranscriptional regulatory potencies, are involved in the pathogenesis of fibrotic diseases and are promising diagnostic biomarkers and therapeutic targets. However, their specific…
View article: CCDC 1994060: Experimental Crystal Structure Determination
CCDC 1994060: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1994057: Experimental Crystal Structure Determination
CCDC 1994057: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …