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View article: Regulation by glutathione of the effect of lymphokines on differentiation of primary activated lymphocytes. Influence of glutathione on cytotoxic activity of CD3-AK-.
Regulation by glutathione of the effect of lymphokines on differentiation of primary activated lymphocytes. Influence of glutathione on cytotoxic activity of CD3-AK-. Open
By activating murine lymphocytes with anti-CD3 antibodies for 1 to 2 days, we generated a subset of activated killer cells, namely CD3-AK-. CD3-AK- mediated the slow lysis (20-h 125I-UdR release assay) of allogeneic P815 but had little eff…
View article: Generation of antisuppressor T cells for alloreactive cytotoxic T lymphocytes.
Generation of antisuppressor T cells for alloreactive cytotoxic T lymphocytes. Open
This study demonstrated that antisuppressor T cells (TAS) were generated in allogeneic mixed lymphocyte culture (MLC) when supplemented with a conditioned medium containing T cell differentiation factor (CM-TCDF). CM-TCDF was shown to effi…
View article: Lymphokine-induced cytotoxicity: requirement of two lymphokines for the induction of optimal cytotoxic response.
Lymphokine-induced cytotoxicity: requirement of two lymphokines for the induction of optimal cytotoxic response. Open
Lymphokines induce the generation of cytotoxic cells (LICC) in the absence of antigenic or mitogenic stimulation. In the present study, we have demonstrated that at least two lymphokines are involved. They are interleukin 2-conditioned med…
View article: Regulation of the activation of cytotoxic T lymphocytes by prostaglandins and antigens.
Regulation of the activation of cytotoxic T lymphocytes by prostaglandins and antigens. Open
The present study demonstrated the presence of two suppressor circuits in the regulation of the in vitro activation and differentiation of cytotoxic T lymphocytes (CTL); these suppressor circuits were mediated by prostaglandins (PG) and an…
View article: Characterization of the responding populations for the generation of proliferative response to syngeneic Meth A tumor in BALB/c mice: requirement of T and B cell collaboration.
Characterization of the responding populations for the generation of proliferative response to syngeneic Meth A tumor in BALB/c mice: requirement of T and B cell collaboration. Open
High levels of primary proliferative response to a chemically induced sarcoma Meth A can be induced in syngeneic BALB/c spleen cells. Testing at the peak of proliferative response (2 days after sensitization in the mixed lymphocyte tumor c…
View article: Switching on the macrophage-mediated suppressor mechanism by tumor cells to evade host immune surveillance.
Switching on the macrophage-mediated suppressor mechanism by tumor cells to evade host immune surveillance. Open
The present study demonstrates a unique mechanism for tumor cell-induced immunosuppression. In the presence of a nonsuppressive dose of tumor cells, generation of cytotoxic T cells in the mixed lymphocyte culture (MLC) is completely suppre…
View article: Immunoregulatory circuit among macrophage subsets for T cell-mediated cytotoxic response to tumor cells.
Immunoregulatory circuit among macrophage subsets for T cell-mediated cytotoxic response to tumor cells. Open
An immunoregulatory circuit exists among macrophage subsets to regulate the Τ cell-mediated cytotoxic response against allogeneic tumor cells. This is shown by the ability of two subsets of macrophages distinguished by their anatomic origi…