Jungho Cha
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View article: Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder
Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder Open
These findings suggest that intraoperative EPs provide valuable insights into ALIC DBS target engagement. EP characteristics may serve as biomarkers to refine DBS targeting and predict clinical response, offering a potential tool for optim…
View article: Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
[This corrects the article DOI: 10.3389/fnhum.2025.1544994.].
View article: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-ge…
View article: Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression
Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression Open
Objective Bile acids may contribute to pathophysiologic markers of Alzheimer’s disease, including disruptions of the executive control network (ECN) and the default mode network (DMN). Cognitive dysfunction is common in major depressive di…
View article: Seizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis
Seizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis Open
Prolonged seizures can disrupt stem cell behavior in the adult hippocampus, an important brain structure for spatial memory. Here, using a mouse model of pilocarpine-induced status epilepticus (SE), we characterized spatiotemporal expressi…
View article: Different effect of hypo- and hypermetabolism on cognition in dementia with Lewy bodies: are they coupled or independent?
Different effect of hypo- and hypermetabolism on cognition in dementia with Lewy bodies: are they coupled or independent? Open
Patients with dementia with Lewy bodies (DLB) show widespread brain metabolic changes. This study investigated whether brain hypo- and hypermetabolism in DLB have differential effects on cognition. We enrolled 55 patients with DLB (15 prod…
View article: Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer’s Disease Continuum
Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer’s Disease Continuum Open
As a part of the glymphatic system, the choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain. We investigated the association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition in patients on th…
View article: Whole brain network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression
Whole brain network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression Open
Ongoing experimental studies of subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD) show a differential timeline of behavioral effects with rapid changes after initial stimulation, and both early…
View article: Cingulate dynamics track depression recovery with deep brain stimulation
Cingulate dynamics track depression recovery with deep brain stimulation Open
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error s…
View article: Distinct amyloid-dependent patterns of nigra dopamine depletion in Lewy body diseases
Distinct amyloid-dependent patterns of nigra dopamine depletion in Lewy body diseases Open
Introduction Concomitant amyloid pathology is not uncommon and contributes to the clinical characteristics of Lewy body disease (LBD). We investigated the effect of amyloid on striatal 18 F-FP-CIT uptake patterns in LBD, including Parkinso…
View article: Whole Brain Network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression
Whole Brain Network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression Open
Ongoing experimental studies of subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD) show a differential timeline of behavioral effects with rapid changes after initial stimulation, and both early…
View article: Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy
Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy Open
Remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or comb…
View article: Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum
Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum Open
Our findings suggest that BG-, CSO-, and HP-EPVS are not associated with baseline β-amyloid burden or cognitive function independently of SVD at the diagnosis of AD continuum. However, CSO-EPVS appears to be associated with the progression…
View article: Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury Open
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open pla…
View article: Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression
Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression Open
Background: Hippocampal atrophy has been consistently reported in major depressive disorder with more recent focus on subfields. However, literature on hippocampal volume changes after antidepressant treatment has been limited. The first-l…
View article: Diffusion tensor imaging‐based pontine damage as a degeneration marker in synucleinopathy
Diffusion tensor imaging‐based pontine damage as a degeneration marker in synucleinopathy Open
The pons is one of the earliest affected regions in patients with synucleinopathies. We aimed to investigate the diagnostic value of measuring pontine damage using diffusion tensor imaging (DTI) in these patients. We enrolled 49 patients w…
View article: Altered cerebrocerebellar functional connectivity in patients with obstructive sleep apnea and its association with cognitive function
Altered cerebrocerebellar functional connectivity in patients with obstructive sleep apnea and its association with cognitive function Open
Study Objectives Previous functional MRI studies have reported altered brain networks in patients with obstructive sleep apnea (OSA). However, the extent and pattern of abnormal connectivity were inconsistent across studies, and cerebrocer…
View article: Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature Open
Background It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Methods Serum samples (baseline, 12 weeks) were dra…
View article: Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease
Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease Open
Purpose The aim of this study was to investigate the association between autonomic dysfunction and striatal dopamine depletion or metabolic changes in de novo Parkinson disease (PD). Methods Based on the Composite Autonomic Severity Score …
View article: 0724 Altered Brain Network Organization in Patients With Obstructive Sleep Apnea
0724 Altered Brain Network Organization in Patients With Obstructive Sleep Apnea Open
Introduction Previous functional MRI (fMRI) studies have reported altered brain networks in patients with obstructive sleep apnea (OSA), but the extent of such abnormal connectivity was inconsistent across studies. Moreover, despite the im…
View article: Neurophysiological signatures in Alzheimer’s disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline
Neurophysiological signatures in Alzheimer’s disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline Open
Alpha and delta-theta brain oscillation deficits depict diverse associations with amyloid and TAU accumulations and with cognitive decline in AD.