Jung‐Ick Byun
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View article: Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy
Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy Open
Background Natural killer (NK) cells are key effector lymphoid cells involved in both innate and adaptive immunity and are capable of clearing abnormally aggregated α-synuclein (αSyn). In preclinical Parkinson’s disease (PD) models, NK cel…
View article: Abnormal theta- and gamma-band cortical activities during visuospatial attention in idiopathic REM sleep behavior disorder patients
Abnormal theta- and gamma-band cortical activities during visuospatial attention in idiopathic REM sleep behavior disorder patients Open
View article: 831 | A PHASE 1, MULTICENTER, FIRST‐IN‐HUMAN TRIAL OF GCC2005, AN ALLOGENEIC CAR‐NK CELL THERAPY TARGETING CD5, IN PATIENTS WITH RELAPSED/REFRACTORY NK AND T‐CELL MALIGNANCIES
831 | A PHASE 1, MULTICENTER, FIRST‐IN‐HUMAN TRIAL OF GCC2005, AN ALLOGENEIC CAR‐NK CELL THERAPY TARGETING CD5, IN PATIENTS WITH RELAPSED/REFRACTORY NK AND T‐CELL MALIGNANCIES Open
View article: A Survey of Korean Neurologists’ Awareness, Clinical Practice, Education, and Challenges in Sleep Medicine
A Survey of Korean Neurologists’ Awareness, Clinical Practice, Education, and Challenges in Sleep Medicine Open
Background: Despite the critical importance of sleep medicine within neurology, notable gaps in education and clinical practice persist among neurologists. This study aims to explore the extent of involvement and the challenges faced by Ko…
View article: Effect of High-Definition Transcranial Direct Current Stimulation on Cognitive Function in REM Sleep Behavior Disorder: a sham-controlled pilot study
Effect of High-Definition Transcranial Direct Current Stimulation on Cognitive Function in REM Sleep Behavior Disorder: a sham-controlled pilot study Open
View article: Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial Open
This study failed to demonstrate the therapeutic effect of pregabalin compared with placebo for RLS in Korean adults. Possible reasons for the negative results include low dose, insufficient sample size, and substantial placebo response. F…
View article: Effect of Parietal High-Definition Transcranial Direct Current Stimulation on Cognitive Function in REM Sleep Behavior Disorder With Mild Cognitive Impairment: A Sham-Controlled Pilot Study
Effect of Parietal High-Definition Transcranial Direct Current Stimulation on Cognitive Function in REM Sleep Behavior Disorder With Mild Cognitive Impairment: A Sham-Controlled Pilot Study Open
View article: Low arousal threshold is associated with altered functional connectivity of the ascending reticular activating system in patients with obstructive sleep apnea
Low arousal threshold is associated with altered functional connectivity of the ascending reticular activating system in patients with obstructive sleep apnea Open
View article: FORECAST-RBD: Forecasting Phenoconversion Risks and Its Clinical Phenotype in Patients with Isolated RBD Using Machine Learning and Explainable AI
FORECAST-RBD: Forecasting Phenoconversion Risks and Its Clinical Phenotype in Patients with Isolated RBD Using Machine Learning and Explainable AI Open
Background and Objectives Isolated Rapid Eye Movement (REM) sleep behavior disorder (iRBD) is a sleep disorder associated with neurodegenerative diseases such as Parkinson’s disease and dementia with Lewy bodies. Predicting which iRBD pati…
View article: Risk of encephalitis and meningitis after COVID-19 vaccination in South Korea: a self-controlled case series analysis
Risk of encephalitis and meningitis after COVID-19 vaccination in South Korea: a self-controlled case series analysis Open
Background Several neurological manifestations shortly after a receipt of coronavirus infectious disease 2019 (COVID-19) vaccine have been described in the recent case reports. Among those, we sought to evaluate the risk of encephalitis an…
View article: Effect of Non-Invasive Brain Stimulation on Sleep and Sleep Disorders
Effect of Non-Invasive Brain Stimulation on Sleep and Sleep Disorders Open
Non-invasive brain stimulation (NIBS), including transcranial magnetic and electrical stimulations, has recently been used to modulate sleep and treat sleep disorders. Herein, we reviewed studies that used NIBS to modulate sleep in healthy…
View article: ALTERED FUNCTIONAL CONNECTIVITY OF THE ASCENDING RETICULAR ACTIVATING SYSTEM IN OBSTRUCTIVE SLEEP APNEA
ALTERED FUNCTIONAL CONNECTIVITY OF THE ASCENDING RETICULAR ACTIVATING SYSTEM IN OBSTRUCTIVE SLEEP APNEA Open
View article: Risk Evaluation and Management of Post-Stroke Epilepsy
Risk Evaluation and Management of Post-Stroke Epilepsy Open
Seizure is an important complication following ischemic or hemorrhagic stroke in older adults. Post-stroke seizure can be classified as early or late according to the onset time after stroke. There is a 71% risk for further seizures after …
View article: EEG-based Machine Learning Models for the Prediction of Phenoconversion Time and Subtype in iRBD
EEG-based Machine Learning Models for the Prediction of Phenoconversion Time and Subtype in iRBD Open
Background Idiopathic/Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson’s disease (PD), dementia with…
View article: Expert Opinion on Current Polysomnography Procedure for Diagnosis of Rapid Eye Movement Sleep Behavior Disorder in Korea
Expert Opinion on Current Polysomnography Procedure for Diagnosis of Rapid Eye Movement Sleep Behavior Disorder in Korea Open
Rapid eye movement (REM) sleep behavior disorder (RBD) is diagnosed based on a history of dream-enactment behavior and documentation of REM sleep without atonia (RWA) on polysomnography (PSG). RWA can be quantified using various methods. T…
View article: Quantitative Network Comparisons of REM Sleep Without Atonia Across the α-Synucleinopathy Spectrum: A Systematic Review
Quantitative Network Comparisons of REM Sleep Without Atonia Across the α-Synucleinopathy Spectrum: A Systematic Review Open
CRD42021276445.
View article: Change of iron content in brain regions after intravenous iron therapy in restless legs syndrome: quantitative susceptibility mapping study
Change of iron content in brain regions after intravenous iron therapy in restless legs syndrome: quantitative susceptibility mapping study Open
Study Objectives The pathomechanism of restless legs syndrome (RLS) is related to brain iron deficiency and iron therapy is effective for RLS; however, the effect of iron therapy on human brain iron state has never been studied with magnet…
View article: Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea
Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea Open
Repeated arousals during sleep in obstructive sleep apnea (OSA) may lead to altered functional connectivity (FC) of the ascending reticular activating system (ARAS). We evaluated resting-state FC between eight ARAS nuclei and 105 cortical/…
View article: Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by explainable machine learning using 3D convolutional neural network
Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by explainable machine learning using 3D convolutional neural network Open
Isolated rapid eye movement sleep behavior disorder (iRBD) is a sleep disorder characterized by dream enactment behavior without any neurological disease and is frequently accompanied by cognitive dysfunction. The purpose of this study was…
View article: Quantitative measurement of motor activity during sleep in isolated REM sleep behavior disorder patients using actigraphy before and after treatment with clonazepam
Quantitative measurement of motor activity during sleep in isolated REM sleep behavior disorder patients using actigraphy before and after treatment with clonazepam Open
Study Objectives We conducted a prospective study to quantify motor activity during sleep measured by actigraphy before and after 3 months of treatment with clonazepam in patients with video-polysomnography (vPSG) confirmed isolated rapid …
View article: 0510 Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea
0510 Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea Open
Introduction Recurrent arousals in obstructive sleep apnea (OSA) may lead to alteration in functional connection involving in the ascending reticular activating system (ARAS). We aimed to evaluate resting-state functional connectivity (FC)…
View article: 0715 Machine Learning Model to Predict Isolated REM Sleep Behavior Disorder Phenoconversion Time and Subtype using EEG
0715 Machine Learning Model to Predict Isolated REM Sleep Behavior Disorder Phenoconversion Time and Subtype using EEG Open
Introduction More than 80% of patients of isolated rapid eye movement (REM) sleep behavior disorder (iRBD), a prodromal disease of α-synucleinopathies, progress to neurological disease like Parkinson's disease (PD), dementia with Lewy bodi…
View article: Management of convulsive status epilepticus: recent updates
Management of convulsive status epilepticus: recent updates Open
Convulsive status epilepticus (SE) is a medical emergency associated with high morbidity and mortality. Recently, clinical trials and meta-analyses investigating medical treatment of SE have been published. Benzodiazepine is well known as …
View article: Deep learning signature of brain [18F]FDG PET associated with cognitive outcome of rapid eye movement sleep behavior disorder
Deep learning signature of brain [18F]FDG PET associated with cognitive outcome of rapid eye movement sleep behavior disorder Open
An objective biomarker to predict the outcome of isolated rapid eye movement sleep behavior disorder (iRBD) is crucial for the management. This study aimed to investigate cognitive signature of brain [ 18 F]FDG PET based on deep learning (…
View article: Emotional and Environmental Factors Aggravating Dream Enactment Behaviors in Patients with Isolated REM Sleep Behavior Disorder
Emotional and Environmental Factors Aggravating Dream Enactment Behaviors in Patients with Isolated REM Sleep Behavior Disorder Open
Our results suggest that DEBs in iRBD patients may be mainly aggravated by emotional factors. These negative effects appeared to be more prominent in female and depressed patients.
View article: Metabolic Effect of Obstructive Sleep Apnea in Patients Undergoing Bariatric Surgery
Metabolic Effect of Obstructive Sleep Apnea in Patients Undergoing Bariatric Surgery Open
Objectives: The prevalence of obstructive sleep apnea (OSA) and its association with perioperative comorbidities in patients who undergo bariatric surgery remain unclear in South Korea. We investigated the prevalence of OSA and its associa…
View article: Comparison of rapid eye movement without atonia quantification methods to diagnose rapid eye movement sleep behavior disorder: a systematic review
Comparison of rapid eye movement without atonia quantification methods to diagnose rapid eye movement sleep behavior disorder: a systematic review Open
Study Objectives Rapid eye movement (REM) sleep without atonia (RWA) is essential for diagnosing REM sleep behavior disorder (RBD). Manual and automatic quantifications of RWA that use different criteria have been validated. This study com…
View article: Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs
Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs Open
Several medications are approved to treat coronavirus disease 2019 (COVID-19) in Korea including nirmatrelvir/ritonavir, remdesivir, and regdanvimab. There is potential drug-drug interaction between antiepileptic drugs (AEDs) and the medic…
View article: White Matter Tract-Specific Microstructural Disruption is Associated with Depressive Symptoms in Isolated Rbd
White Matter Tract-Specific Microstructural Disruption is Associated with Depressive Symptoms in Isolated Rbd Open
View article: Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder
Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder Open
The results obtained in this study support that cortical cholinergic activity is impaired in iRBD patients with MCI. FC between NBM and posterior regions may play a central role in the cognitive function of these patients.