Junhui Zhen
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View article: LM-Searcher: Cross-domain Neural Architecture Search with LLMs via Unified Numerical Encoding
LM-Searcher: Cross-domain Neural Architecture Search with LLMs via Unified Numerical Encoding Open
Recent progress in Large Language Models (LLMs) has opened new avenues for solving complex optimization problems, including Neural Architecture Search (NAS). However, existing LLM-driven NAS approaches rely heavily on prompt engineering an…
View article: Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD
Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD Open
Key Points Lysosomal-associated protein transmembrane 5 (LAPTM5) is increased in tubular epithelial cells in CKD. Conditional knockout of Laptm5 in tubules attenuates kidney fibrosis in mice with CKD. LAPTM5 contributes to tubular senescen…
View article: Small extracellular vesicles-shuttled miR-23a-3p from mesenchymal stem cells alleviate renal fibrosis and inflammation by inhibiting KLF3/STAT3 axis in diabetic kidney disease
Small extracellular vesicles-shuttled miR-23a-3p from mesenchymal stem cells alleviate renal fibrosis and inflammation by inhibiting KLF3/STAT3 axis in diabetic kidney disease Open
Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (MSC-sEV) provide a pragmatic solution as a cell-free therapy for patients with diabetic kidney disease (DKD). However, the underlying protective mechanisms o…
View article: IgA nephropathy with podocytic infolding glomerulopathy
IgA nephropathy with podocytic infolding glomerulopathy Open
(A) Immunofluorescence staining showed moderate immunoglobulin A depositions in the mesangial areas (++) of glomeruli (Bars = 100 μm). (B) Segmentally mild mesangial proliferation and mesangial matrix expansion (arrowhead) with mild thicke…
View article: Development of a multiple convolutional neural network–facilitated diagnostic screening program for immunofluorescence images of IgA nephropathy and idiopathic membranous nephropathy
Development of a multiple convolutional neural network–facilitated diagnostic screening program for immunofluorescence images of IgA nephropathy and idiopathic membranous nephropathy Open
Background Immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) are the most common glomerular diseases. Immunofluorescence (IF) tests of renal tissues are crucial for the diagnosis. We developed a multiple convo…
View article: HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice Open
Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. Here, we find …
View article: Leptin Promotes HTR-8/SVneo Cell Invasion via the Crosstalk between MTA1/WNT and PI3K/AKT Pathways
Leptin Promotes HTR-8/SVneo Cell Invasion via the Crosstalk between MTA1/WNT and PI3K/AKT Pathways Open
The process of placental invasion is essential for a successful pregnancy. Leptin is involved in trophoblast invasiveness, and its dysregulation is connected with a series of diseases, including preeclampsia. However, the knowledge of the …
View article: Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy
Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy Open
Podocyte damage is strongly associated with the progression of diabetic nephropathy. Mitotic catastrophe plays an essential role in accelerating podocyte loss and detachment from the glomerular basement membrane. In the current study, we o…
View article: Kidney injury molecule‑1 levels are associated with therapeutic outcomes and renal tubulointerstitial injury severity in idiopathic membranous nephropathy
Kidney injury molecule‑1 levels are associated with therapeutic outcomes and renal tubulointerstitial injury severity in idiopathic membranous nephropathy Open
Kidney injury molecule-1 (KIM-1) has an important role in chronic kidney disease development. The present study aimed to retrospectively analyze patients with idiopathic membranous nephrology (IMN) with different therapeutic outcomes to in…
View article: Role of SIK1 in the transition of acute kidney injury into chronic kidney disease
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease Open
Background Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in renal diseases. Rec…
View article: Resveratrol alleviates obesity‑associated podocyte injury in ovariectomized obese rats
Resveratrol alleviates obesity‑associated podocyte injury in ovariectomized obese rats Open
Obesity-associated podocyte injury increases in parallel with inflammatory responses. Resveratrol, as an anti-inflammatory and antioxidative agent, has been proven to be effective in obesity. The purpose of the present study was to investi…
View article: Systemic lupus erythematosus with Guillian–Barre syndrome
Systemic lupus erythematosus with Guillian–Barre syndrome Open
Introduction: We report a case of systemic lupus erythematosus (SLE) with Guillian–Barre syndrome (GBS) as the first symptom. Case presentation: A 30-year-old Chinese female with numbness and inductance of lower extremities 2 months previo…
View article: Pantoprazole‑induced acute kidney injury: A case report
Pantoprazole‑induced acute kidney injury: A case report Open
The present study reports a case of pantoprazole-induced acute kidney disease. The patient was diagnosed with acute kidney injury with wide interstitial inflammation and eosinophil infiltration. Following 1 month of glucocorticoid therapy,…
View article: Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice Open
Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-…
View article: Lnc<scp>RNA MALAT</scp>1 is dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury <i>via</i> its interplay with β‐catenin
Lnc<span>RNA MALAT</span>1 is dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury <i>via</i> its interplay with β‐catenin Open
Metastasis associated lung adenocarcinoma transcript 1( MALAT 1) is a long non‐coding RNA , broadly expressed in mammalian tissues including kidney and up‐regulated in a variety of cancer cells. To date, its functions in podocytes are larg…
View article: Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats
Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats Open
The aim of the present study was to investigate the protective effect of tacrolimus on early podocyte damage in rats with diabetic nephropathy (DN). A total of 38 normal male Sprague‑Dawley rats were randomly divided into four groups: Norm…
View article: <scp>FAK</scp> contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F‐actin re‐organization <i>via</i> activating p38 in response to ox‐<scp>LDL</scp>
<span>FAK</span> contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F‐actin re‐organization <i>via</i> activating p38 in response to ox‐<span>LDL</span> Open
Focal adhesion kinase ( FAK ) is a non‐receptor protein tyrosine kinase that regulates cell adhesion, proliferation and differentiation. In the present study, a rat model of high fat diet‐induced hypercholesterolaemia was established to in…
View article: Resveratrol attenuates acute kidney injury by inhibiting death receptor-mediated apoptotic pathways in a cisplatin-induced rat model
Resveratrol attenuates acute kidney injury by inhibiting death receptor-mediated apoptotic pathways in a cisplatin-induced rat model Open
Acute kidney injury is a clinical syndrome characterized by a loss of renal function and acute tubular necrosis. Resveratrol exerts a wide range of pharmacological effects based on its anti‑inflammatory, antioxidant and cytoprotective prop…
View article: Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity
Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity Open
Nephrotoxicity is a relevant limitation of gentamicin, and obese patients have an increased risk for gentamicin-induced kidney injury. This damage is thought to depend on the accumulation of the drug in the renal cortex. Obese rats showed …
View article: IgG4-related disease: a case report with duration of more than 16 years and review of literature
IgG4-related disease: a case report with duration of more than 16 years and review of literature Open
IgG4-related disease is a systemic fibro-inflammatory immune-mediated disorder and progresses slowly. In the present patient the course of IgG4-related disease appears to be benign. The prognosis of IgG4-related disease depend on early dia…
View article: Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation<i> In Vitro</i>
Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation<i> In Vitro</i> Open
Fyn, a member of the Src family of tyrosine kinases, is a key regulator in cytoskeletal remodeling in a variety of cell types. Recent studies have demonstrated that Fyn is responsible for nephrin tyrosine phosphorylation, which will result…
View article: Mycophenolate mofetil ameliorates diabetic nephropathy through epithelial mesenchymal transition in rats
Mycophenolate mofetil ameliorates diabetic nephropathy through epithelial mesenchymal transition in rats Open
Recent studies in animal models have revealed that mycophenolate mofetil (MMF) has certain protective effects against experimental diabetic nephropathy. The present study therefore aimed to investigate the hypothesis that diabetic nephropa…
View article: Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate Restores Nrf2 Activity and Ameliorates Crescentic Glomerulonephritis
Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate Restores Nrf2 Activity and Ameliorates Crescentic Glomerulonephritis Open
Crescentic glomerulonephritis (GN) is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy with steroids, cytotoxic drugs, and plasmapheresis. We examined the therapeutic ef…