Junhui Zhou
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View article: Geographic variation in functional compounds and multi-element of Lithocarpus litseifolius: insights from chemical profiling and ecological drivers
Geographic variation in functional compounds and multi-element of Lithocarpus litseifolius: insights from chemical profiling and ecological drivers Open
Lithocarpus litseifolius (Hance) Chun (LL), is a high-value edible and medicinal plant, prized for its unique flavor, health benefits and a vital role in increasing farmers' incomes. It is extensively cultivated in multiple provinces in Ch…
View article: Genome-Wide Identification of SWEET Genes and Expression Dynamics of MrSWEET15 During Fruit Ripening in Chinese Bayberry (Morella rubra)
Genome-Wide Identification of SWEET Genes and Expression Dynamics of MrSWEET15 During Fruit Ripening in Chinese Bayberry (Morella rubra) Open
Sugar transporters of the SWEET family play a crucial role in sugar partitioning and fruit quality, yet their functions remain uncharacterized in Chinese bayberry (Morella rubra). In this study, we present the first genome-wide identificat…
View article: Multi-omics to hormonal signaling networks: Decoding growth-defense trade-offs underlying growth-retardation in two-year-old cultivated ginseng (Panax ginseng C.A. Mey.)
Multi-omics to hormonal signaling networks: Decoding growth-defense trade-offs underlying growth-retardation in two-year-old cultivated ginseng (Panax ginseng C.A. Mey.) Open
Growth retardation in two-year-old cultivated ginseng (Panax ginseng) is driven by spatiotemporal antagonism between jasmonate (JA) and auxin signaling networks, leading to resource allocation imbalances between defense and growth. Integra…
View article: Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi
Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi Open
The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy. In such patients, pe…
View article: PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection
PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection Open
Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. Here we sh…
View article: Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent
Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent Open
The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy. In such patients, pe…
View article: Challenges of continuous cropping obstacles in Panax ginseng: Formation and response mechanisms
Challenges of continuous cropping obstacles in Panax ginseng: Formation and response mechanisms Open
Panax ginseng , a perennial herbaceous plant and a representative of the Panax genus, is renowned for its exceptional medicinal value and economic benefits, often referred to as the “King of Herbs.” With the increasing market demand and th…
View article: PGLYRP-1 mediated intracellular peptidoglycan detection promotes mucosal protection
PGLYRP-1 mediated intracellular peptidoglycan detection promotes mucosal protection Open
Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. W…
View article: Synthesis of a Borrelia burgdorferi-Derived Muropeptide Standard Fragment Library
Synthesis of a Borrelia burgdorferi-Derived Muropeptide Standard Fragment Library Open
The interplay between the human innate immune system and bacterial cell wall components is pivotal in understanding diseases such as Crohn’s disease and Lyme arthritis. Lyme disease, caused by Borrelia burgdorferi, is the most prevalent ti…
View article: A <i>Syringa pinnatifolia</i> genome assembly reveals the zerumbone biosynthesis machinery with a cytochrome P450‐catalysed epoxidation reaction in eudicots
A <i>Syringa pinnatifolia</i> genome assembly reveals the zerumbone biosynthesis machinery with a cytochrome P450‐catalysed epoxidation reaction in eudicots Open
Syringa pinnatifolia, a shrub within the Syringa genus of the Oleaceae family (Figure S1), is valued in traditional Chinese medicine for its volatile chemical constituents. These principally include a suite of humulane-type monocyclic sesq…
View article: Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus
Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus Open
The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is a need to develop more effective and safer mpox virus (MPXV)-specific vaccines in response to…
View article: Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron
Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron Open
BACKGROUNDAs Omicron is prompted to replicate in the upper airway, neutralizing antibodies (NAbs) delivered through inhalation might inhibit early-stage infection in the respiratory tract. Thus, elucidating the prophylactic efficacy of NAb…
View article: Comparison of red raspberry and wild strawberry fruits reveals mechanisms of fruit type specification
Comparison of red raspberry and wild strawberry fruits reveals mechanisms of fruit type specification Open
Belonging to Rosaceae, red raspberry (Rubus idaeus) and wild strawberry (Fragaria vesca) are closely related species with distinct fruit types. While the numerous ovaries become the juicy drupelet fruits in raspberry, their strawberry coun…
View article: The association between character strengths and job crafting among nurses in tertiary hospitals: A cross‐sectional survey
The association between character strengths and job crafting among nurses in tertiary hospitals: A cross‐sectional survey Open
Aim This study was to investigate the association between character strengths and job crafting among nurses in tertiary hospitals in China. Design A cross‐sectional survey was conducted. Methods From February 2021 to April 2021, 1006 nurse…
View article: A first-in-human clinical study of an intranasal spray of a cocktail containing two synergetic antibodies neutralizes Omicron BA.4/5
A first-in-human clinical study of an intranasal spray of a cocktail containing two synergetic antibodies neutralizes Omicron BA.4/5 Open
Neutralizing monoclonal antibodies (NAbs) with prophylactic and therapeutic efficacy have demonstrated fundamental importance in the control of SARS-CoV-2 transmission. However, their wide application has been largely limited by high cost …
View article: Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family Open
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted to certain species/tribes in this family. Little is known about …
View article: Effects of anterolateral femoral free flap transplantation on the repair of soft tissue defect of hands and feet and risk factors for flap necrosis.
Effects of anterolateral femoral free flap transplantation on the repair of soft tissue defect of hands and feet and risk factors for flap necrosis. Open
Anterolateral femoral free flap transplantation is beneficial to improve the clinical outcomes in patients with hand or foot soft tissue defects, increase the survival rate of skin flap and promote recovery. Incomplete hemostasis during op…
View article: Rapid and Visual Detection of Monkey B Virus Based on Recombinase Polymerase Amplification
Rapid and Visual Detection of Monkey B Virus Based on Recombinase Polymerase Amplification Open
Objective: Monkey B virus (BV) infection in humans and other macaque species has a mortality rate of approximately 80%. Because BV infects humans through bites, scratches, and other injuries inflicted by macaques, the simple and rapid diag…
View article: Facile Hydrothermal Synthesis of Cu2MoS4 and FeMoS4 for Efficient Adsorption of Chlortetracycline
Facile Hydrothermal Synthesis of Cu2MoS4 and FeMoS4 for Efficient Adsorption of Chlortetracycline Open
Contamination of antibiotics in an aqueous environment has attracted wide attention. Developing high-efficiency adsorbents for antibiotics removal is urgent. In this work, two kinds of ternary transition metal chalcogenides—Cu2MoS4 and FeM…
View article: Metabolic and Transcriptional Stress Memory in Sorbus pohuashanensis Suspension Cells Induced by Yeast Extract
Metabolic and Transcriptional Stress Memory in Sorbus pohuashanensis Suspension Cells Induced by Yeast Extract Open
Plant stress memory can provide the benefits of enhanced protection against additional stress exposure. Here, we aimed to explore the responses of recurrent and non-recurrent yeast extract (YE) stresses in Sorbus pohuashanensis suspension …
View article: Increased pathogenicity and aerosol transmission for one SARS-CoV-2 B.1.617.2 Delta variant over the wild-type strain in hamsters
Increased pathogenicity and aerosol transmission for one SARS-CoV-2 B.1.617.2 Delta variant over the wild-type strain in hamsters Open
During the two-year pandemic of coronavirus disease 2019 (COVID-19), its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been evolving. SARS-CoV-2 Delta, a variant of concern, has become the dominant circ…