Explanipedia

Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL Open

Jun’ichi Kobayashi, Masatomo Kawakubo, Chifumi Fujii, Nobuhiko Arisaka, Masaki Miyashita , et al. · 2021

Significance Cholesteryl-α-D-glucopyranoside (CGL) is a cell wall constituent of Helicobacter pylori . It is synthesized by cholesterol α-glucosyltransferase, which transfers glucose from UDP-glucose to a carbon atom at the third position …

Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate Open

Girish Beedessee, Takaaki Kubota, Asuka Arimoto, Koki Nishitsuji, Ross F. Waller , et al. · 2020

Abundance of cell‐free mitochondrial DNA in spent culture medium associated with morphokinetics and blastocyst collapse of expanded blastocysts Open

Mitsuru Kobayashi, Jun’ichi Kobayashi, Koumei Shirasuna, Hisataka Iwata · 2020

Purpose This retrospective observational study investigated relationships between the abundance of cell‐free mitochondrial DNA (cf‐mtDNA) in spent culture medium (SCM) of human‐expanded blastocysts and their morphokinetics to address the q…

Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma Open

Kei Tsuchihashi, Munehide Nakatsugawa, Jun’ichi Kobayashi, Takashi Sasaya, Rena Morita , et al. · 2020

bMF may act as a novel biomarker for OSCC.

Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma Open

Kazushige Koike, Hironari Dehari, Shota Shimizu, Koyo Nishiyama, Tomoko Sonoda , et al. · 2020

Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartme…

Selective Neck Dissection and Survival in Pathologically Node-Positive Oral Squamous Cell Carcinoma Open

Shunichi Shimura, Kazuhiro Ogi, Akihiro Miyazaki, Shota Shimizu, Takeshi Kaneko , et al. · 2019

The most important prognostic factor in oral squamous cell carcinoma (OSCC) is neck metastasis, which is treated by neck dissection. Although selective neck dissection (SND) is a useful tool for clinically node-negative OSCC, its efficacy …

Tumor‐infiltrating CD8+ T‐cell density is an independent prognostic marker for oral squamous cell carcinoma Open

Shota Shimizu, Hiroyoshi Hiratsuka, Kazushige Koike, Kei Tsuchihashi, Tomoko Sonoda , et al. · 2019

Background The presence of tumor‐infiltrating lymphocytes (TILs) is associated with improved survival in head and neck squamous cell carcinoma. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC). M…

Uncommon presentation of desmoplastic fibroblastoma on the tongue of a female patient Open

Takaaki Tokura, Jun’ichi Kobayashi, Junya Okamoto, Akihiro Miyazaki · 2018

Desmoplastic fibroblastoma (DF) is a rare benign soft tissue with spindle-to-stellate-shaped fibroblasts and myofibroblasts embedded in a prominent collagenous background. DF, mainly affecting subcutaneous and muscle tissue, very rarely oc…

Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 Open

Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima , et al. · 2018

Diverticulum of the buccal mucosa: a rare case report and review of the literature Open

Akihiro Miyazaki, Shô Miyamoto, Hiromi Nakai, Koyo Nishiyama, Kei Tsuchihashi , et al. · 2018

A case of schwannoma of the oral floor that showed high uptake on FDG-PET/CT Open

Takeshi Kaneko, Akihiro Miyazaki, Jun’ichi Kobayashi, Shouta Shimizu, Kazushige Koike , et al. · 2018

Schwannoma originate in the Schwann sheath of peripheral nerves; the incidence of schwannoma in the oral and maxillofacial region is low. We describe our experience with a patient who had a schwannoma that showed high uptake on a FDG-PET/C…

Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion Open

Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi , et al. · 2018

Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1…

CCDC 1871284: Experimental Crystal Structure Determination Open

Hayato Suzuki, Hiroshi Morita, Motoo Shiro, Jun’ichi Kobayashi · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma Open

Junya Okamoto, Akihiro Miyazaki, Jun’ichi Kobayashi, Sho Miyamoto, Takanori Sasaki , et al. · 2017

These data indicated that the TcOTM clone recognized a TAA presented by HLA-A24 cells. This unique method will allow for identification of unknown TAAs for OSCC in the future.

Time-lapse monitoring demonstrates that preincubation time after oocyte retrieval is unrelated to fertilization and its use in clinical practice enables optimization in workflow Open

H. Watanabe, M. Kobayashi, H. Hasegawa, Ryo Suzuki, K. Tsukamoto , et al. · 2017

Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review Open

Hitoshi Yoshimura, Seigo Ohba, Hisato Yoshida, Kyoko Saito, Kazuyoshi Inui , et al. · 2017

Denosumab, a human monoclonal antibody directed against the receptor activator of nuclear factor-κβ ligand (RANKL), is used for the treatment of patients with metastatic cancer of the bone or osteoporosis. Recent reports have demonstrated …

The impact of preincubation time between oocytes retrieval and intracytoplasmic sperm injection (ICSI) on fertilization and embryo quality by age Open

M. Kobayashi, H. Watanabe, H. Hasegawa, K. Tsukamoto, Ryo Suzuki , et al. · 2016

Yezo’otogirins D–H, Acylphloroglucinols and Meroterpenes from Hypericum yezoense Open

Naonobu Tanaka, Eri Tsuji, Yoshiki Kashiwada, Jun’ichi Kobayashi · 2016

Investigation of the methanolic extract from the aerial parts of Hypericum yezoense resulted in the isolation of three new acylphloroglucinols, yezo'otogirins D-F (1-3), and two new meroterpenes, yezo'otogirins G (4) and H (5). The structu…

A Case of Propitocaine-induced Methemoglobinemia During Extraction of Wisdom Teeth Under General Anesthesia Open

Dai Ichikawa, Hitoshi Yoshimura, Hisato Yoshida, Rie Yasui, Minako Aiki , et al. · 2016

Methemoglobinemia is characterized by increased methemoglobin in the circulating blood. Methemoglobin is useless as an oxygen carrier; thus, methemoglobinemia could lead to hypoxemia due to the limited availability of hemoglobin for oxygen…

Therapeutic experience with teriparatide in a patient with chronic sclerosing osteomyelitis of the mandible associated with SAPHO syndrome Open

Michiyo Onishi, Akihiro Miyazaki, Jun’ichi Kobayashi, Megumi Ueda, Makoto Shimanishi , et al. · 2016

Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by sterile osteomyelitis and pustular skin disease. Little is known about its pathogenesis, and no effective treatment methods have been established to date.…

Table of Contents Open

Gianluca Plotino, Hany Aly, Nicola Maria Grande, Stephen M. Cohen, Fr Eric Bukiet , et al. · 2015

Diminished Progression of Periapical Lesions with Zoledronic Acid in Ovariectomized Rats Open

Marcelo Tadahiro Wayama, Hitoshi Yoshimura, Seigo Ohba, Hisato Yoshida, Shinpei Matsuda , et al. · 2015

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis Open

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin-ichiro Iio , et al. · 2015

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in…

A case of myoepithelial carcinoma ex pleomorphic adenoma of the hard palate Open

Kazuhiro Ogi, Jun’ichi Kobayashi, Kousuke Takeda, Takashi Ide, Akihiro Miyazaki , et al. · 2015

Carcinoma ex pleomorphic adenoma mainly occurs in the major salivary gland, and a tissue type of myoepithelial carcinoma is extremely rare in the minor salivary gland.We report a case of myoepithelial carcinoma ex pleomorphic adenoma of th…

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis Open

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin-Ichiro Iio , et al. · 2015

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of <…

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis Open

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin-Ichiro Iio , et al. · 2015

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of <…

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis Open

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin-Ichiro Iio , et al. · 2015

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of <…

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