Junichi Sugita
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View article: A comparative study of GVHD prophylaxis using low dose ATG versus PTCy for PBSCT based on two independent prospective cohorts
A comparative study of GVHD prophylaxis using low dose ATG versus PTCy for PBSCT based on two independent prospective cohorts Open
Both anti-thymocyte globulin (ATG) and post-transplant cyclophosphamide (PTCy) have shown prophylactic effects on graft-versus-host disease (GVHD) in multiple phase III studies. We conducted a comparative study of for low dose ATG (thymogl…
View article: HLA-haploidentical stem cell transplantation using posttransplant cyclophosphamide
HLA-haploidentical stem cell transplantation using posttransplant cyclophosphamide Open
View article: Current status of conditioning regimens in haploidentical hematopoietic cell transplantation
Current status of conditioning regimens in haploidentical hematopoietic cell transplantation Open
The development of effective prophylaxis strategies against graft-versus-host disease (GVHD) has contributed to the widespread use of haploidentical related hematopoietic cell transplantation (Haplo-HCT). Currently, GVHD prophylaxis contai…
View article: Long-term follow-up of efficacy and safety in elderly patients with chronic myeloid leukemia treated with intermittent low dose dasatinib therapy
Long-term follow-up of efficacy and safety in elderly patients with chronic myeloid leukemia treated with intermittent low dose dasatinib therapy Open
Intermittent low dose dasatinib therapy brought about a beneficial effect in elderly patients with chronic-phase chronic myeloid leukemia (CML-CP) without inducing severe adverse events (AEs). An 85-year-old male patient, who received twic…
View article: Efficacy and Safety of Single-dose Pegfilgrastim for CD34+ Cell Mobilization in Healthy Volunteers: A Phase 2 Study
Efficacy and Safety of Single-dose Pegfilgrastim for CD34+ Cell Mobilization in Healthy Volunteers: A Phase 2 Study Open
Background. Pegfilgrastim, a long-acting form of granulocyte-colony stimulating factor, with a convenient single-injection dosage, is being investigated for peripheral blood stem cell (PBSC) mobilization in healthy volunteers. However, dat…
View article: HokUS-10 scoring system predicts the treatment outcome for sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation
HokUS-10 scoring system predicts the treatment outcome for sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation Open
Hepatic sinusoidal obstruction syndrome (SOS) is a severe and life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a multi-center retrospective study to evaluate the utility of our ult…
View article: Posttransplant cyclophosphamide in HLA-matched and 1-2 allele mismatched peripheral blood stem cell transplantation
Posttransplant cyclophosphamide in HLA-matched and 1-2 allele mismatched peripheral blood stem cell transplantation Open
Posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis has been increasingly used in HLA-haploidentical transplantation and recent studies also demonstrated the efficacy of PTCy in HLA-matched transplanta…
View article: Issue Information
Issue Information Open
Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia
View article: Donor Lymphocyte Infusion for Relapsed Acute Leukemia or Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation: A Single-Institute Retrospective Analysis
Donor Lymphocyte Infusion for Relapsed Acute Leukemia or Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation: A Single-Institute Retrospective Analysis Open
Objective The prognosis of the patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is poor, and therapeutic options are limited. In the present study, we investigated the efficacy and factors associat…
View article: Correction to: Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
Correction to: Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation Open
View article: Post-hoc analysis of a clinical study on extracorporeal photopheresis in patients with chronic graft-versus-host disease in Japan
Post-hoc analysis of a clinical study on extracorporeal photopheresis in patients with chronic graft-versus-host disease in Japan Open
体外フォトフェレーシス(ECP)は,ステロイド抵抗性,依存性または不耐容の慢性移植片対宿主病(GVHD)患者を対象とした国内臨床試験の結果により,2020年12月に慢性GVHDに対する二次治療のための高度管理医療機器として薬事承認された。今回,この臨床試験に登録された15例を対象としてECP治療開始から36週までの治療効果や安全性をpost-hoc解析した。3例が試験を中止し,36週まで完了した患者は12例であった。ステロイド投与量はECP開始前より減量した患者は36週で1…
View article: Predictors of impaired antibody response after <scp>SARS‐CoV</scp>‐2 <scp>mRNA</scp> vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study
Predictors of impaired antibody response after <span>SARS‐CoV</span>‐2 <span>mRNA</span> vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study Open
HCT recipients reportedly have a high mortality rate after developing COVID‐19. SARS‐CoV‐2 vaccination is generally useful to prevent COVID‐19. However, its safety and efficacy among HCT recipients remain elusive. This large‐scale prospect…
View article: Endoscopic balloon dilations for strictures of rectum, ileocecal valve and duodenum in a patient with X-linked inhibitor of apoptosis deficiency: a case report
Endoscopic balloon dilations for strictures of rectum, ileocecal valve and duodenum in a patient with X-linked inhibitor of apoptosis deficiency: a case report Open
X-linked inhibitor of apoptosis (XIAP) deficiency is a rare primary immunodeficiency and gastrointestinal (GI) lesions in XIAP deficiency are similar to Crohn’s disease. For patients with Crohn’s disease, endoscopic balloon dilation (EBD) …
View article: A Case of Cecal Cancer with Invasion of the Inguinal Canal Developing on a Mesh
A Case of Cecal Cancer with Invasion of the Inguinal Canal Developing on a Mesh Open
われわれは鼠径ヘルニア術後のPlugに沿って局所浸潤した盲腸癌の１例を経験したので報告する．症例は70歳男性，両側の鼠径ヘルニアに対してMesh-Plug法での修復術の既往あり．便潜血陽性のため消化管精査し，盲腸癌の診断であった．CT検査で盲腸腫瘍からPlugに連続した脂肪織濃度上昇を認め，鼠径管内への局所浸潤を疑った．腹腔鏡下に観察の後，回盲部切除術，D3郭清および前方アプローチでメッシュを含む鼠径管内要物摘出術を施行した．病理組織学的検査では，Plugの線維に沿って腫瘍…
View article: A Case of a Neuroendocrine Neoplasm of the Appendix in a Child
A Case of a Neuroendocrine Neoplasm of the Appendix in a Child Open
症例は13歳男児，右下腹部痛のため来院し，膿瘍形成性虫垂炎の診断で保存的加療を行った．治療後に再燃をきたしたため，待機的に腹腔鏡下虫垂切除術を施行した．術後の病理組織学的診断でChromogranin A陽性，Synaptophysin陽性，Ki-67陽性率＜１％で虫垂原発神経内分泌腫瘍WHO分類（2019）NET G1と診断された．脈管侵襲は認めなかったため，追加治療は施行せず経過観察し，無再発生存している．本疾患は小児においては極めて稀であり，特徴的な画像所見に乏しく術…
View article: Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript
Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript Open
Right neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary …
View article: Performance of Qualitative and Quantitative Antigen Tests for SARS-CoV-2 Using Saliva
Performance of Qualitative and Quantitative Antigen Tests for SARS-CoV-2 Using Saliva Open
The rapid detection of SARS-CoV-2 is critical for the prevention of disease outbreaks. Antigen tests such as immunochromatographic assay (ICA) and chemiluminescent enzyme immunoassay (CLEIA) can yield results more quickly than PCR. We eval…
View article: Clinical outcomes of intervention for carbapenems and anti-methicillin-resistant Staphylococcus aureus antibiotics by an antimicrobial stewardship team
Clinical outcomes of intervention for carbapenems and anti-methicillin-resistant Staphylococcus aureus antibiotics by an antimicrobial stewardship team Open
View article: Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors
Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors Open
View article: Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation Open
View article: Factors for the Variability of Three Acceptable Maximal Expiratory Flow–Volume Curves in Chronic Obstructive Pulmonary Disease
Factors for the Variability of Three Acceptable Maximal Expiratory Flow–Volume Curves in Chronic Obstructive Pulmonary Disease Open
Both FVC and FEV1 are highly reproducible; nevertheless, older age, lower FEV1 at baseline, and non-emphysema phenotype are factors for a higher variability in FEV1 in patients with COPD.
View article: Donor Cell-derived Anaplastic Large Cell Lymphoma after 27-year Remission of Acute Promyelocytic Leukemia Followed by Successful Allogeneic Hematopoietic Stem Cell Transplantation
Donor Cell-derived Anaplastic Large Cell Lymphoma after 27-year Remission of Acute Promyelocytic Leukemia Followed by Successful Allogeneic Hematopoietic Stem Cell Transplantation Open
54歳，男性．27歳時に，急性前骨髄球性白血病に対してHLA（human leukocyte antigen）適合の兄からの骨髄移植を受けた．右大腿のケロイド様皮疹生検の結果，ALK（anaplastic lymphoma kinase）陰性未分化大細胞リンパ腫（anaplastic large cell lymphoma：ALCL）の診断となった．電子線治療を施行したが，他部位に再発があり，リンパ節病変の生検検体によるキメリズム解析にて，ドナー細胞由来リンパ腫であることを…
View article: The Combined Usage of the Global Leadership Initiative on Malnutrition Criteria and Controlling Nutrition Status Score in Acute Care Hospitals
The Combined Usage of the Global Leadership Initiative on Malnutrition Criteria and Controlling Nutrition Status Score in Acute Care Hospitals Open
Introduction: The Global Leadership Initiative on Malnutrition (GLIM) lacks reliable blood tests for evaluating the nutrition status. We retrospectively compared the GLIM criteria, Controlling Nutrition Status (CONUT) score, …
View article: Cytokine release syndrome after HLA-haploidentical stem cell transplantation with posttransplant cyclophosphamide
Cytokine release syndrome after HLA-haploidentical stem cell transplantation with posttransplant cyclophosphamide Open
同移植後シクロホスファミドを用いたHLA半合致移植（PTCYハプロ）はGVHDや非再発死亡のリスクが低く広く行われるようになっているが，注意すべき合併症の1つにサイトカイン放出症候群（CRS）がある。CRSは高サイトカイン血症によって引き起こされる症候群でありさまざまな症状が出現しうるが，移植片輸注後早期の高度の発熱が特徴的である。ほとんどの患者ではPTCY投与後は速やかに解熱するが，一部の患者では重症CRSを発症することがある。重症CRS患者にはトシリズマブが使用可能であ…
View article: Pharmacokinetics of mycophenolic acid after haplo-hematopoietic stem cell transplantation in Japanese recipients
Pharmacokinetics of mycophenolic acid after haplo-hematopoietic stem cell transplantation in Japanese recipients Open
Purpose Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) prodrug, is used to prevent graft-versus-host disease (GVHD) in hematopoietic stem cell transplantation (HSCT). Although previous studies have reported that enterohepatic circu…
View article: SARS-CoV-2 detection by fluorescence loop-mediated isothermal amplification with and without RNA extraction
SARS-CoV-2 detection by fluorescence loop-mediated isothermal amplification with and without RNA extraction Open
View article: Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva
Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva Open
Background Coronavirus disease 2019 (COVID-19) has rapidly evolved to become a global pandemic, largely owing to the transmission of its causative virus through asymptomatic carriers. Detection of severe acute respiratory syndrome coronavi…
View article: Mass screening of asymptomatic persons for SARS-CoV-2 using saliva
Mass screening of asymptomatic persons for SARS-CoV-2 using saliva Open
Background COVID-19 has rapidly evolved to become a global pandemic due largely to the transmission of its causative virus through asymptomatic carriers. Detection of SARS-CoV-2 in asymptomatic people is an urgent priority for the preventi…
View article: Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification
Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification Open
View article: Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva
Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva Open