Junitta Guzman
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View article: Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque Open
Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to spinal motor neurons (SMNs) and SMN subtypes, we generated single-cell multiome datasets from …
View article: Technical and biological sources of noise confound multiplexed enhancer AAV screening
Technical and biological sources of noise confound multiplexed enhancer AAV screening Open
Cis -acting regulatory enhancer elements are valuable tools for gaining cell type-specific genetic access. Leveraging large chromatin accessibility atlases, putative enhancer sequences can be identified and deployed in adeno-associated vir…
View article: Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice Open
Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function1,2. Mammalian brains consist of thousands of cell types3, which may be differentially susceptible or resilient to a…
View article: Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development
Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development Open
The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the de…
View article: Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque Open
Summary Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to lower motor neurons (LMNs) and LMN subtypes, we generated single cell multiome dataset…
View article: The transcriptomic and spatial organization of telencephalic GABAergic neuronal types
The transcriptomic and spatial organization of telencephalic GABAergic neuronal types Open
The telencephalon of the mammalian brain comprises multiple regions and circuit pathways that play adaptive and integrative roles in a variety of brain functions. There is a wide array of GABAergic neurons in the telencephalon; they play a…
View article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Open
The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional properties 1–3 . Here we report a comprehensive and high-resolu…
View article: Molecular hallmarks of Alzheimer’s disease with a multimodal single cell atlas of the cortex
Molecular hallmarks of Alzheimer’s disease with a multimodal single cell atlas of the cortex Open
Background The Seattle Alzheimer’s Disease Cell Atlas (SEA‐AD, https://sea-ad.org ) is a large‐scale effort to identify, at single cell resolution, the cellular and molecular mechanisms that cause AD and facilitate its progression. SEA‐AD …
View article: Interindividual variation in human cortical cell type abundance and expression
Interindividual variation in human cortical cell type abundance and expression Open
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumo…
View article: Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas
Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas Open
Biological aging can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Aging is a complex and dynamic process which influences distinct cell types in a myriad of ways. The cellular archi…
View article: SEA‐AD: Scientific analysis and open access resources targeting early changes in Alzheimer’s disease
SEA‐AD: Scientific analysis and open access resources targeting early changes in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most common form of dementia, representing ∼70% of all dementia cases, and affecting much of the aged population. Currently our understanding of AD neuropathology is largely centered on characteri…
View article: Integrated multimodal cell atlas of Alzheimer’s disease
Integrated multimodal cell atlas of Alzheimer’s disease Open
Alzheimer’s disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive and stereotyped accumulation of protein aggregates, but the underlying molecular and cellu…
View article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Open
The mammalian brain is composed of millions to billions of cells that are organized into numerous cell types with specific spatial distribution patterns and structural and functional properties. An essential step towards understanding brai…
View article: Inter-individual variation in human cortical cell type abundance and expression
Inter-individual variation in human cortical cell type abundance and expression Open
Single cell transcriptomic studies have identified a conserved set of neocortical cell types from small post-mortem cohorts. We extend these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumor…