Junji Akagi
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View article: Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients
Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients Open
H2 gas inhalation combined with CCRT is feasible and safe for patients with LAHNC.
View article: Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD‑1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD‑1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer Open
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibi…
View article: Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study
Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study Open
Creatinine (Cr) levels are strongly affected by muscle mass, and the estimated glomerular filtration rate (eGFR), a measure based on serum creatinine (SCr), is often overestimated in patients with sarcopenia. To evaluate the coefficient of…
View article: Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis
Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis Open
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in …
View article: Terminally differentiated CD8+ T cells and CD57‑FOXP3+CD8+ T cells are highly associated with the efficacy of immunotherapy using activated autologous lymphocytes
Terminally differentiated CD8+ T cells and CD57‑FOXP3+CD8+ T cells are highly associated with the efficacy of immunotherapy using activated autologous lymphocytes Open
Treatment with activated autologous lymphocytes (AALs) has demonstrated mixed results for cancer treatment. Preliminary results revealed that the proportion of cluster of differentiation (CD)8+CD57+ T cells is signifi…
View article: CD57 ratio as a convenient and useful immunological and prognostic parameter for stage�IV carcinoma
CD57 ratio as a convenient and useful immunological and prognostic parameter for stage�IV carcinoma Open
Cluster of differentiation (CD)8+CD57+ T cells are derived through the CD8+ T cell-differentiation signaling pathway from early differentiated CD27+CD8+CD57-T cells (early-CD8+ T cells) to terminal-differentiated CD27-CD8+CD57+ T cells (te…
View article: Nutritional variables predict chances of returning home and activities of daily living in post-acute geriatric care
Nutritional variables predict chances of returning home and activities of daily living in post-acute geriatric care Open
Malnutrition and nutritional intake are associated with returning home and ADL at discharge, respectively, after post-acute care. Further studies investigating the effects of a nutritional intervention for post-acute patients would be nece…
View article: Interferential current sensory stimulation, through the neck skin, improves airway defense and oral nutrition intake in patients with dysphagia: a double-blind randomized controlled trial
Interferential current sensory stimulation, through the neck skin, improves airway defense and oral nutrition intake in patients with dysphagia: a double-blind randomized controlled trial Open
TESS, using interferential current through the neck, improved airway defense and nutrition in patients suffering from dysphagia. Further large-scale studies are needed to confirm the technique's effect on swallowing ability.
View article: FENS News
FENS News Open
View article: Decreased Skeletal Muscle Mass and Risk Factors of Sarcopenic Dysphagia: A Prospective Observational Cohort Study
Decreased Skeletal Muscle Mass and Risk Factors of Sarcopenic Dysphagia: A Prospective Observational Cohort Study Open
This study provides evidence for sarcopenic dysphagia and its risk factors. Preventive and therapeutic interventions require further study.