Junji Umeno
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View article: A Multicenter Observational Study for the Establishment of Novel Severity Criteria Including Endoscopic Evaluation for Intestinal Behçet's Disease
A Multicenter Observational Study for the Establishment of Novel Severity Criteria Including Endoscopic Evaluation for Intestinal Behçet's Disease Open
Objective This study aimed to establish a novel severity classification for intestinal Behçet's disease (BD) (SCIBD) and validate its criteria across multiple institutions. Methods Five parameters, including abdominal pain, tenderness, int…
View article: Chronic Enteropathy Associated with SLCO2A1 Gene
Chronic Enteropathy Associated with SLCO2A1 Gene Open
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al. [J Jpn Soc Gastroe…
View article: Duodenal Duplication Diagnosed by Computed Tomography-Duodenography and Treated by Endoscopy
Duodenal Duplication Diagnosed by Computed Tomography-Duodenography and Treated by Endoscopy Open
A 21-year-old man with a developmental disability presented for management of upper abdominal pain and vomiting. He was diagnosed by endoscopy and computed tomography-duodenography as having duodenal obstruction due to duodenal duplication…
View article: Endoscopic features of solitary colorectal hamartomatous polyps: Solitary juvenile polyp and Peutz-Jeghers polyp
Endoscopic features of solitary colorectal hamartomatous polyps: Solitary juvenile polyp and Peutz-Jeghers polyp Open
The aim of this study was to clarify the endoscopic characteristics of colorectal hamartomatous polyps, including solitary juvenile polyp (JP) and solitary Peutz-Jeghers polyp (PJP). We reviewed the clinicopathological and endoscopic findi…
View article: Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study Open
Background This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) in Japan, using real-world data, and aimed to establish genotype-based treatment strat…
View article: ARGINASE 2 AMELIORATES EXPERIMENTAL COLITIS THROUGH ANTIOXIDANT EFFECTS VIA SPERMIDINE PRODUCTION
ARGINASE 2 AMELIORATES EXPERIMENTAL COLITIS THROUGH ANTIOXIDANT EFFECTS VIA SPERMIDINE PRODUCTION Open
BACKGROUND Spermidine which is a type of polyamine, shows elevated levels in patients with ulcerative colitis and is implicated in the pathogenesis of ulcerative colitis (UC). Arginase 2 (ARG2) plays a critical role in spermidine productio…
View article: MAINTENANCE EFFICACY OF ORAL INDIGO NATURALIS FOR ULCERATIVE COLITIS: A SINGLE-CENTER, OPEN-LABEL, RANDOMIZED, CONTROLLED STUDY
MAINTENANCE EFFICACY OF ORAL INDIGO NATURALIS FOR ULCERATIVE COLITIS: A SINGLE-CENTER, OPEN-LABEL, RANDOMIZED, CONTROLLED STUDY Open
BACKGROUND Indigo naturalis (IN) is one of the herbal medicines in Chinese medicine. Recent reports have demonstrated a strong remission induction efficacy of oral IN in induction therapy for ulcerative colitis (UC), but the efficacy of IN…
View article: Issue Information
Issue Information Open
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View article: White Blood Cell Counts and Future Relapse in Ulcerative Colitis under Low-Dose Thiopurine Treatment in Real-World Practice: A 3-Year Japanese Multi-Center Retrospective Cohort Study
White Blood Cell Counts and Future Relapse in Ulcerative Colitis under Low-Dose Thiopurine Treatment in Real-World Practice: A 3-Year Japanese Multi-Center Retrospective Cohort Study Open
Introduction: Whether white blood cell (WBC) counts are predictors for the effectiveness of thiopurine treatment in ulcerative colitis (UC) has been inconclusive in previous studies with small sample sizes. We investigated th…
View article: Disease Flares Following COVID-19 Vaccination in Patients with Inflammatory Bowel Disease
Disease Flares Following COVID-19 Vaccination in Patients with Inflammatory Bowel Disease Open
Objective Flares of inflammatory bowel disease (IBD) can occur infrequently after vaccination for coronavirus disease 2019 (COVID-19), although the details of this phenomenon are poorly understood. To clarify the possibility of an unfavora…
View article: Gastrointestinal: Peutz–Jeghers syndrome with a novel frameshift mutation in <i>STK 11</i> gene observed by magnifying narrowband imaging endoscopy
Gastrointestinal: Peutz–Jeghers syndrome with a novel frameshift mutation in <i>STK 11</i> gene observed by magnifying narrowband imaging endoscopy Open
A 62-year-old woman was admitted to our institution because of intermittent melena. Her past medical history included cervical intraepithelial neoplasia. She had no family history of gastrointestinal polyposes. Esophagogastroduodenoscopy r…
View article: Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis
Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis Open
Objective T helper (Th) cells play a central role in the pathogenesis of ulcerative colitis (UC). The present study analyzed the changes in circulating T cells by administration of ustekinumab (UST), an interleukin-12/23p40 antibody. Metho…
View article: Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries Open
View article: Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Surrogate Marker of Small Bowel Mucosal Injury in Crohn’s Disease
Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Surrogate Marker of Small Bowel Mucosal Injury in Crohn’s Disease Open
Introduction: Although the importance of mucosal healing has been suggested in Crohn’s disease, it is difficult to repeat endoscopy, especially for the entire small bowel. Recently, serum leucine-rich alpha-2 glycoprotein (LRG) has been us…
View article: Supplementary Material for: White blood cell counts and future relapse in ulcerative colitis under low-dose thiopurine treatment in real-world practice: a three year Japanese multi-center retrospective cohort study.
Supplementary Material for: White blood cell counts and future relapse in ulcerative colitis under low-dose thiopurine treatment in real-world practice: a three year Japanese multi-center retrospective cohort study. Open
Introduction Whether white blood cell (WBC) counts are predictors for the effectiveness of thiopurine treatment in ulcerative colitis (UC) has been inconclusive in previous studies with small sample sizes. We investigated the association b…
View article: Multicenter epidemiological survey of pneumatosis intestinalis in Japan
Multicenter epidemiological survey of pneumatosis intestinalis in Japan Open
Background Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine the etiology and affected segments associated with complications, treatment, and outcome. Methods We…
View article: Tu1546: JAPAN PROSPECTIVE MULTICENTER STUDY FOR OPTIMIZATION OF COVID-19 VACCINATIONS BASED ON THE IMMUNE RESPONSE AND SAFETY PROFILE IN INFLAMMATORY BOWEL DISEASE PATIENTS: INTERIM ANALYSES
Tu1546: JAPAN PROSPECTIVE MULTICENTER STUDY FOR OPTIMIZATION OF COVID-19 VACCINATIONS BASED ON THE IMMUNE RESPONSE AND SAFETY PROFILE IN INFLAMMATORY BOWEL DISEASE PATIENTS: INTERIM ANALYSES Open
View article: One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study
One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study Open
Background/Aims: Recent studies suggested a favorable effect of indigo naturalis (IN) in inducing remission for refractory ulcerative colitis (UC), however, the maintenance effect of IN for patients with UC remains unknown. Therefore, we c…
View article: Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method
Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method Open
View article: DOP24 Japan prospective multicenter study for optimization of COVID-19 vaccinations based on the immune response and safety profile in Inflammatory Bowel Disease patients: Interim analyses of the J-COMBAT trial
DOP24 Japan prospective multicenter study for optimization of COVID-19 vaccinations based on the immune response and safety profile in Inflammatory Bowel Disease patients: Interim analyses of the J-COMBAT trial Open
Background Immune responses to the SARS-CoV-2 vaccination may be influenced by immunomodulatory drugs (IMDs). We investigated the immune responses and safety in fully vaccinated Japanese patients with IBD. Methods IBD patients and control …
View article: Supplementary Material for: The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy
Supplementary Material for: The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy Open
Introduction: An association has been found between human-gut microbiota and various diseases (e.g., metabolic disease) by analyzing fecal or colonic microbiota. Despite the importance of the small intestinal microbiota, samp…
View article: Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers
Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers Open
View article: Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma
Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma Open
To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori -negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis. Although some gastric MALT lymphomas are associated wit…
View article: Risk of Rebleeding in Patients with Small Bowel Vascular Lesions
Risk of Rebleeding in Patients with Small Bowel Vascular Lesions Open
Objective With recent advances in endoscopic modalities, small bowel vascular lesions (SBVLs) are often now detected in patients with gastrointestinal bleeding. Given the high invasiveness of endoscopic treatment, it is important to select…
View article: Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis Open
View article: SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy
SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy Open
View article: Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations
Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifica…
View article: Chronic Nonspecific Multiple Ulcers of the Small Intestine / Chronic Enteropathy Associated with <I>SLCO2A1</I> Gene (CEAS)
Chronic Nonspecific Multiple Ulcers of the Small Intestine / Chronic Enteropathy Associated with <i>SLCO2A1</i> Gene (CEAS) Open
非特異性多発性小腸潰瘍症は，病理組織学的に特異的所見のない潰瘍が小腸に多発する疾患である．プロスタグランジン輸送体をコードするSLCO2A1遺伝子の変異を原因とする．男女比は1：2と女性に多く，貧血や低蛋白血症をきたす難治性疾患である．経過中，約半数の症例で腸管切除が必要となる．小腸病変は回腸に好発し，輪走，斜走する浅い潰瘍や多発狭窄という特徴を有する．診断には臨床経過，小腸病変の形態的評価のほか，上部消化管病変や消化管外徴候の有無が参考となり，SLCO2A1遺伝子検査も有…
View article: Supplementary Material for: Ustekinumab Improves Active Crohn’s Disease by Suppressing the T Helper 17 Pathway
Supplementary Material for: Ustekinumab Improves Active Crohn’s Disease by Suppressing the T Helper 17 Pathway Open
Background: Ustekinumab (UST), an antibody targeting the p40 subunit of interleukin (IL)-12 and IL-23, is effective in treating Crohn’s disease (CD). To clarify the mechanism of UST, we investigated T-cell differentiation in …
View article: Chronic Enteropathy Associated with <i>SLCO2A1</i> with Pachydermoperiostosis
Chronic Enteropathy Associated with <i>SLCO2A1</i> with Pachydermoperiostosis Open
A 49-year-old man complained of chronic palpitation and shortness of breath, which had recently become exacerbated. A blood examination indicated severe refractory anemia and hypoproteinemia. Physical examinations revealed anemia, a systol…