Junjiao Zhang
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View article: Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing Open
Recurrent synovial bleeding is the major cause of Hemophilic Arthritis (HA). Up to now, the transcriptomic profiles of bleeding syvonium in HA patient have largely remained unknown. Exploring the transcriptomic characteristics of synovium …
View article: Analysis and prospect of ‘Chinese Educational Modernization Policy’: a textual study based on 155 policy documents
Analysis and prospect of ‘Chinese Educational Modernization Policy’: a textual study based on 155 policy documents Open
Education modernization is the core issue of China’s education reform and development, which have received significant attention in the aspects of policy formulation, academic research and practical exploration in recent years. This study …
View article: Molecular messengers of the brain: tRNA-derived small RNAs at the crossroads of brain development and neurodevelopmental disorders
Molecular messengers of the brain: tRNA-derived small RNAs at the crossroads of brain development and neurodevelopmental disorders Open
Brain development is tightly regulated by different modulators and mechanisms. Disruptions in these processes underlie a spectrum of neurodevelopmental disorders. Among non-coding RNAs, which usually act as key regulators of brain developm…
View article: Tamibarotene promotes differentiation of neuroblastoma SH-SY5Y cells into neurons, which is associated with activation of the PI3K/AKT signaling pathway
Tamibarotene promotes differentiation of neuroblastoma SH-SY5Y cells into neurons, which is associated with activation of the PI3K/AKT signaling pathway Open
Tamibarotene, a synthetic retinoid used in the treatment of acute promyelocytic leukemia, has been reported to induce differentiation in the SH-SY5Y cell line into neurons. However, the underlying mechanisms remain unclear. This study aime…
View article: Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy
Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy Open
Introduction Genetic generalized epilepsy (GGE) involves polygenic inheritance, with emerging evidence implicating immune mechanisms in seizure pathogenesis. Unlike previous studies focusing on inflammation following seizures, we employed …
View article: Carbonized Dual-Layer Balsa Wood Membrane for Efficient Oil–Water Separation in Kitchen Applications
Carbonized Dual-Layer Balsa Wood Membrane for Efficient Oil–Water Separation in Kitchen Applications Open
Wood-based membranes have garnered increasing attention due to their structural advantages and durability in the efficient treatment of oily kitchen wastewater. However, conventional fabrication methods often rely on toxic chemicals or syn…
View article: Effects of the Small‐Molecule <scp>ISRIB</scp> on the Rapid and Efficient Myelination of Oligodendrocytes in Human Stem Cell‐Derived Cerebral Organoids in Patients With Leukoencephalopathy With Vanishing White Matter
Effects of the Small‐Molecule <span>ISRIB</span> on the Rapid and Efficient Myelination of Oligodendrocytes in Human Stem Cell‐Derived Cerebral Organoids in Patients With Leukoencephalopathy With Vanishing White Matter Open
Introduction Leukoencephalopathy with vanishing white matter (VWM) is a rare genetic disorder caused by mutations in any one of the EIF2B 1–5, which encode subunits of eukaryotic translation initiation factor 2B (eIF2B). Previous studies s…
View article: Mechanistic Insights into Drug-Induced Guillain–Barré Syndrome: A Large-Cohort Analysis of the FAERS Database
Mechanistic Insights into Drug-Induced Guillain–Barré Syndrome: A Large-Cohort Analysis of the FAERS Database Open
Background/Objectives: Drug-induced Guillain–Barré Syndrome (GBS) is a severe complication of pharmacotherapy. Previous research has established a connection between certain medications and higher GBS risk. However, a large-cohort analysis…
View article: TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression
TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression Open
Targeting protein for Xklp2 (TPX2) is critical for mitosis and spindle assembly because of its control of Aurora kinase A (AURKA). However, the regulation of TPX2 activity and its subsequent effects on mitosis and cancer progression remain…
View article: Treatment for Dyskinesia in Parkinson's Disease: A Network Meta‐analysis of Randomized Controlled Trials
Treatment for Dyskinesia in Parkinson's Disease: A Network Meta‐analysis of Randomized Controlled Trials Open
Background Dyskinesia is a motor complication of Parkinson's disease (PD) posing therapeutic challenges. The optimal therapy for dyskinesia in PD has not been identified due to the lack of comprehensive evaluation of treatments. Objective …
View article: Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021
Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021 Open
Objective To predict the global, regional, and national prevalence of Parkinson’s disease by age, sex, year, and Socio-demographic Index to 2050 and quantify the factors driving changes in Parkinson’s disease cases. Design Modelling study.…
View article: The Burden of Alzheimer's Disease and Other Dementias, and Parkinson's Disease Among Middle-Aged Adults During 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021
The Burden of Alzheimer's Disease and Other Dementias, and Parkinson's Disease Among Middle-Aged Adults During 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021 Open
View article: Morphological Characteristics and Extracellular Matrix Abnormalities in Astrocytes Derived From <scp>iPSCs</scp> of Children With Alexander Disease
Morphological Characteristics and Extracellular Matrix Abnormalities in Astrocytes Derived From <span>iPSCs</span> of Children With Alexander Disease Open
Aims Alexander disease (AxD) is a leukodystrophy caused by mutations in the astrocytic filament gene GFAP . There are currently no effective treatments for AxD. Previous studies have rarely established AxD models with the patient's origina…
View article: Efficient Separation of Oil/Water by a Biodegradable and Superhydrophobic Composite Based on Loofah and Rice Straw
Efficient Separation of Oil/Water by a Biodegradable and Superhydrophobic Composite Based on Loofah and Rice Straw Open
Membrane filtration is one of the preferred choices for petroleum wastewater disposal due to its simplicity and low energy consumption. In this paper, a biodegradable superhydrophobic membrane based on loofah and rice straw (LF-RS) was pre…
View article: Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs
Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs Open
This work was supported by grants from the National Nature Science Foundation of China (Grant No. 82271459).
View article: EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β Open
View article: Research on the Construction of Teacher Professional Learning. Community in the Web 3.0 Era
Research on the Construction of Teacher Professional Learning. Community in the Web 3.0 Era Open
China’s teacher education reform has always advocated the establishment of a teacher-professional learning community to promote teacher professional development and school progress. In the Web 3.0 era, the increasingly open, secure, and fa…
View article: Iron deposition in subcortical nuclei of Parkinson’s disease: A meta-analysis of quantitative iron-sensitive magnetic resonance imaging studies
Iron deposition in subcortical nuclei of Parkinson’s disease: A meta-analysis of quantitative iron-sensitive magnetic resonance imaging studies Open
Background: Iron deposition plays a crucial role in the pathophysiology of Parkinson’s disease (PD), yet the distribution pattern of iron deposition in the subcortical nuclei has been inconsistent across previous studies. We aimed to asses…
View article: Bexarotene promotes neuroblastoma SH-SY5Y cells differentiation to mature neurons with decreased proliferation
Bexarotene promotes neuroblastoma SH-SY5Y cells differentiation to mature neurons with decreased proliferation Open
Bexarotene is an retinoid X receptor (RXR) pharmacological agonist that has been demonstrated to treat cutaneous T-cell lymphoma and promising therapeutic potential for neurological diseases. But it still remains unclear whether bexarotene…
View article: The temperature measurement of hydrogen flame based on CCD and IR images
The temperature measurement of hydrogen flame based on CCD and IR images Open
This study explored the relationship between the RGB color space and the temperature of hydrogen flames with thermal reflection principles.The prediction model based on CCD and infrared (IR) image were compared.The model based on RGB diffe…
View article: Prediction the Moisture Content of Corn Straw, Wheat Straw and Rice Straw Based on Near Infrared Spectroscopy
Prediction the Moisture Content of Corn Straw, Wheat Straw and Rice Straw Based on Near Infrared Spectroscopy Open
The calorific value of biomass fuels is affected by the moisture content.In this study, the moisture content in corn straw, wheat straw, and rice straw was measured and predicted based on near-infrared spectroscopy (NIR) data.The predictio…
View article: Prevalence of Parkinson's Disease and its Trend from 1980 to 2023: A Systematic Review and Meta-Analysis
Prevalence of Parkinson's Disease and its Trend from 1980 to 2023: A Systematic Review and Meta-Analysis Open
View article: Functional Evaluation of a Kcnt1 Variant Associated with Epilepsy in Rat
Functional Evaluation of a Kcnt1 Variant Associated with Epilepsy in Rat Open
View article: Treatment for Essential Tremor: A Systematic Review and Bayesian Model-Based Network Meta-Analysis of RCTs
Treatment for Essential Tremor: A Systematic Review and Bayesian Model-Based Network Meta-Analysis of RCTs Open
View article: Optimizing the Controlling Parameters of a Biomass Boiler Based on Big Data
Optimizing the Controlling Parameters of a Biomass Boiler Based on Big Data Open
This paper presents a comprehensive method for optimizing the controlling parameters of a biomass boiler. The historical data are preprocessed and classified into different conditions with the k-means clustering algorithm. The first-order …
View article: Dopaminergic versus anticholinergic treatment effects on physiologic complexity of hand tremor in Parkinson's disease: A randomized crossover study
Dopaminergic versus anticholinergic treatment effects on physiologic complexity of hand tremor in Parkinson's disease: A randomized crossover study Open
Aims Parkinsonian tremor (PT) is regulated by numerous neurophysiological components across multiple temporospatial scales. The dynamics of tremor fluctuation are thus highly complex. This study aimed to explore the effects of different me…
View article: Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis
Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis Open
Background Pathological tau accumulates in the cerebral cortex of Parkinson's disease (PD), resulting in cognitive deterioration. Positron emission tomography (PET) can be used for in vivo imaging of tau protein. Therefore, we conducted a …
View article: Projections for Prevalence of Parkinson's Disease and its Driving Factors in 204 Countries and Territories to 2050: A Systematic Analysis of the Global Burden of Disease Study 2019
Projections for Prevalence of Parkinson's Disease and its Driving Factors in 204 Countries and Territories to 2050: A Systematic Analysis of the Global Burden of Disease Study 2019 Open
View article: Heat treatment’s effect on the wettability of cellulose membranes via a top-down approach
Heat treatment’s effect on the wettability of cellulose membranes via a top-down approach Open
Cellulose is a potential alternative to petroleum-derived polymers, and cellulose membranes are used in many applications such as sensors, flexible materials, and functional membranes. Most bottom-up methods are energy-, chemical-, and tim…
View article: Theoretical study on the interactions between cellulose and different methyltriethoxysilane hydrolysis products
Theoretical study on the interactions between cellulose and different methyltriethoxysilane hydrolysis products Open
Silylation is an effective means of cellulose modification. However, the condensation reaction process between the hydrolysis products of the silane coupling agent and cellulose, as well as the structure of the coating, which both have a s…