Junjie Bao
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View article: HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility
HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility Open
Prior studies have established that myometrial hypoxia during labor is pivotal in intensifying contractions, the alterations in gene expression and histone modifications in myometrial cells under hypoxia have yet to be documented. Here, hy…
View article: <scp>DExD</scp>‐Box Helicase 21 Enhances Myometrial Contractions Through Thrombospondin‐1‐Mediated Increase in Cell Adhesion
<span>DExD</span>‐Box Helicase 21 Enhances Myometrial Contractions Through Thrombospondin‐1‐Mediated Increase in Cell Adhesion Open
During labour, the myometrium transitions from a quiescent to an actively contracting state, governed by changes in gene expression. Identifying the pivotal transcription regulators involved in these gene expression alterations offers a us…
View article: Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders
Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders Open
Background Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various cell types and molec…
View article: MicroRNA-206 functions as a potential oligonucleotide therapeutics in preterm birth
MicroRNA-206 functions as a potential oligonucleotide therapeutics in preterm birth Open
To the Editor: Spontaneous preterm labor (PTL) causes infant morbidity and mortality. Regular uterine contractions were the common characteristics in spontaneous labor at term or PTL. Thus, effective decrease or suppression of myometrial c…
View article: BKCa channels are involved in spontaneous and lipopolysaccharide-stimulated uterine contraction in late gestation mice
BKCa channels are involved in spontaneous and lipopolysaccharide-stimulated uterine contraction in late gestation mice Open
The large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between inflammation, BKCa…
View article: Serpin family E member 1 enhances myometrium contractility by increasing <scp>ATP</scp> production during labor
Serpin family E member 1 enhances myometrium contractility by increasing <span>ATP</span> production during labor Open
The uterine contraction during labor, a process with repetitive hypoxia and high energy consumption, is essential for successful delivery. However, the molecular mechanism of myometrial contraction regulation is unknown. Serpin family E me…
View article: Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states
Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states Open
Using single-cell RNA sequencing and spatial transcriptomics, the myometrium was examined at the single-cell level during pregnancy. We identified spatially distinct cell populations and observed alterations in smooth muscle cells and incr…
View article: Upregulated TIMP1 facilitates and coordinates myometrial contraction by decreasing collagens and cell adhesive capacity during human labor
Upregulated TIMP1 facilitates and coordinates myometrial contraction by decreasing collagens and cell adhesive capacity during human labor Open
Myometrial contraction is one of the key events involved in parturition. Increasing evidence suggests the importance of the extracellular matrix (ECM) in this process, in addition to the functional role of myometrial smooth muscle cells, a…
View article: Editorial: The mechanisms of parturition and preterm birth
Editorial: The mechanisms of parturition and preterm birth Open
EDITORIAL article Front. Endocrinol., 04 April 2023Sec. Developmental Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1179856
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: HIF-1α is essential for the augmentation of myometrial contractility during labor
HIF-1α is essential for the augmentation of myometrial contractility during labor Open
Uterine contraction is crucial for a successful labor and the prevention of postpartum hemorrhage. It is enhanced by hypoxia; however, its underlying mechanisms are yet to be elucidated. In this study, transcriptomes revealed that hypoxia-…
View article: Integrated Proteotranscriptomics of Human Myometrium in Labor Landscape Reveals the Increased Molecular Associated With Inflammation Under Hypoxia Stress
Integrated Proteotranscriptomics of Human Myometrium in Labor Landscape Reveals the Increased Molecular Associated With Inflammation Under Hypoxia Stress Open
During labor, a variety of coordinated physiological and biochemical events cause the myometrium to transition from a quiescent to contractile state; the molecular mechanisms responsible for this transition, however, remain unclear. To bet…
View article: Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats*
Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats* Open
Our previous work has shown that nicotine suppressed lipopolysaccharide (LPS)-induced placental inflammation by inhibiting cytokine release as well as infiltration of leukocytes into the placenta through the cholinergic anti-inflammatory p…
View article: NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure
NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure Open
Our results suggest that NKP30-B7-H6 interaction can aggravate hepatocyte damage, probably through up-regulation of IL-32 expression in HBV-ACLF.