Junken Aoki
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View article: LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex
LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex Open
View article: Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons
Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons Open
View article: Discovery and development of an oral analgesic targeting the α2B adrenoceptor
Discovery and development of an oral analgesic targeting the α2B adrenoceptor Open
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonists such as clonidine and dexmedetomidine exhibit analgesic and opioid-sparing effects. Howev…
View article: Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice
Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice Open
View article: Hyperalgesia in the Psychological Stress-Induced Fibromyalgia Model Shows Sexual Dimorphism Mediated by LPA1 and LPA3
Hyperalgesia in the Psychological Stress-Induced Fibromyalgia Model Shows Sexual Dimorphism Mediated by LPA1 and LPA3 Open
Since the initial report indicating that LPA1 signaling plays a key role in initiating nerve injury-induced neuropathic pain (NeuP), subsequent studies using knockout mice and LPA1/3 antagonists have demonstrated that LPA1 and LPA3 signali…
View article: Roles of Bioactive Lysophospholipids as Immunomodulators
Roles of Bioactive Lysophospholipids as Immunomodulators Open
In addition to direct activation by pathogens and antigens, immune cell functions are further modulated by G protein-coupled receptor (GPCR) signals that are evoked by environmental factors produced in response to immune responses. Recent …
View article: Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission
Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission Open
View article: Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation
Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation Open
View article: Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state
Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state Open
Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the r…
View article: Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate
Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate Open
G protein-coupled receptors (GPCRs) exist in the conformational equilibrium between inactive state and active state, where the proportion of active state in the absence of a ligand determines the basal activity of GPCRs. Although many GPCR…
View article: PROTOTYPIC ANTIDEPRESSANTS ACT AS A G-PROTEIN BIASED LPAR1 AGONIST AND CONTRIBUTE TO ANTIDEPRESSANT EFFECTS
PROTOTYPIC ANTIDEPRESSANTS ACT AS A G-PROTEIN BIASED LPAR1 AGONIST AND CONTRIBUTE TO ANTIDEPRESSANT EFFECTS Open
Background Prototypic antidepressants, such as tricyclic/tetracyclic antidepressants (TCAs), have multiple pharmacological properties and have been considered to be more effective than newer antidepressants, such as selective serotonin reu…
View article: Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions
Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions Open
This review provides an overview of recent advances in mass spectrometric methods for phosphoinositide analysis, with a focus on the separation of regioisomers and acyl chain profiling.
View article: Solid-phase synthesis of polyunsaturated fatty acids facilitates precise structural investigation on FFAR1/4 agonist activities and the inhibition of neutrophil pseudopod formation
Solid-phase synthesis of polyunsaturated fatty acids facilitates precise structural investigation on FFAR1/4 agonist activities and the inhibition of neutrophil pseudopod formation Open
We report the construction of a polyunsaturated fatty acid (PUFA) library by the solid-phase synthesis, the investigation of agonist activities for free fatty acid receptors 1 and 4, and the evaluation of anti-inflammatory effect.
View article: Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation
Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation Open
Lipogenesis-driven metabolic flux is crucial for differentiation of pathogenic Th17 cells. Although our previous CRISPR-based screening identified PLA2G12A as a key player in this process, it has remained obscure how this secreted phosphol…
View article: Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state
Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state Open
Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the r…
View article: Intracellular <scp>TAS2Rs</scp> act as a gatekeeper for the excretion of harmful substances via <scp>ABCB1</scp> in keratinocytes
Intracellular <span>TAS2Rs</span> act as a gatekeeper for the excretion of harmful substances via <span>ABCB1</span> in keratinocytes Open
Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin pr…
View article: Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu
Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu Open
View article: Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils Open
Microglia, the primary immune cells of the central nervous system, play a crucial role in maintaining brain homeostasis through phagocytosis of various substrates, including amyloid-β (Aβ) fibrils, a hallmark of Alzheimer disease (AD) path…
View article: Abstract 1376 LPLAT7 regulates acyl chain profiles at sn-1 position of phospholipids in murine skeletal muscle
Abstract 1376 LPLAT7 regulates acyl chain profiles at sn-1 position of phospholipids in murine skeletal muscle Open
Skeletal muscle consists of both fast- and slow-twitch fibers. Phospholipids (PLs) are essential structural components of cellular membranes, and the diversity of their fatty acid compositions affects membrane fluidity and permeability. Al…
View article: Structural basis for lysophosphatidylserine recognition by GPR34
Structural basis for lysophosphatidylserine recognition by GPR34 Open
View article: Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate
Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate Open
View article: Group <scp>III</scp> secreted phospholipase <scp> A <sub>2</sub> </scp> ‐driven lysophospholipid pathway protects against allergic asthma
Group <span>III</span> secreted phospholipase <span> A <sub>2</sub> </span> ‐driven lysophospholipid pathway protects against allergic asthma Open
Asthma is a chronic inflammatory disease of the airways characterized by recurrent episodes of airway obstruction, hyperresponsiveness, remodeling, and eosinophilia. Phospholipase A 2 s (PLA 2 s), which release fatty acids and lysophosphol…
View article: Maternal Progesterone and Adipose mPRε in Pregnancy Regulate the Embryonic Nutritional State
Maternal Progesterone and Adipose mPRε in Pregnancy Regulate the Embryonic Nutritional State Open
View article: New Dihydropyridine Derivative Attenuates NF-<i>κ</i>B Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line
New Dihydropyridine Derivative Attenuates NF-<i>κ</i>B Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line Open
Activated microglia contribute to many neuroinflammatory diseases in the central nervous system. In this study, we attempted to identify an anti-inflammatory compound that could suppress microglial activation. We performed high-throughput …
View article: Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium
Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium Open
Polycyclic aromatic hydrocarbons (PAHs) contain ≲20% of the carbon in the interstellar medium. They are potentially produced in circumstellar environments (at temperatures ≳1000 kelvin), by (~10 kelvin) interstellar clouds, or by processin…
View article: Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies
Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies Open
Lysophosphatidic acid (LPA) is a key player in many physiological and pathophysiological processes. The biological activities of LPA are mediated through interactions with-at least-six subtypes of G-protein-coupled receptors (GPCRs) named …
View article: Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma
Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma Open
Cancer cells harness lipid metabolism to promote their own survival. We screened 47 cancer cell lines for survival dependency on phosphatidylserine (PS) synthesis using a PS synthase 1 (PTDSS1) inhibitor and found that B cell lymphoma is h…
View article: Improving the Signal Intensity of Cryosections Using a Conductive Adhesive Film in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Improving the Signal Intensity of Cryosections Using a Conductive Adhesive Film in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Open
The matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) technique was used to obtain the molecular images of cryosections without labeling. Although MALDI-MSI has been widely used to detect small molecules fro…
View article: PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation
PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation Open
Yes-associated protein (YAP) is a transcriptional coactivator that is essential for the malignancy of various cancers. We have previously shown that YAP activity is positively regulated by phosphatidylserine (PS) in recycling endosomes (RE…
View article: Disease-related PSS1 mutant impedes the formation and function of osteoclasts
Disease-related PSS1 mutant impedes the formation and function of osteoclasts Open
Phosphatidylserine (PS) is an acidic phospholipid that is involved in various cellular events. Heterologous dominant mutations have been identified in the gene encoding PS synthase 1 (PSS1) in patients with a congenital disease called Lenz…