Junlan Qiu
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View article: Thymopentin Enhances Antitumor Immunity Through Thymic Rejuvenation and T Cell Functional Reprogramming
Thymopentin Enhances Antitumor Immunity Through Thymic Rejuvenation and T Cell Functional Reprogramming Open
Background/Objectives: T cell dysfunction represents a fundamental barrier to effective cancer immunotherapy. Although immune checkpoint blockades and adoptive cell transfer have achieved clinical success, therapeutic resistance remains pr…
View article: Gestational glucocorticoid exposure impaired endothelial nitric oxide synthesis via downregulating IP3 receptor 3 expression in male offspring vessels
Gestational glucocorticoid exposure impaired endothelial nitric oxide synthesis via downregulating IP3 receptor 3 expression in male offspring vessels Open
Background: Antenatal glucocorticoid administration represents a standard therapeutic intervention for preterm birth; however, its long-term consequences on vascular endothelial function in offspring remain poorly understood. Nitric oxide …
View article: A meta‐analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus
A meta‐analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus Open
This study aims to comprehensively evaluate the association between gestational diabetes mellitus (GDM) and the risk of chronic diseases, including obesity, glycolipid metabolic disorders, neurodevelopmental conditions and cardiovascular d…
View article: Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study
Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study Open
Background A relationship between frailty index (FI) and metabolic diseases (MDs) has been reported in previous observational studies. However, the causality between them remains unclear. This study aimed to examine the causal effect of FI…
View article: Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels
Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels Open
The present study is the first to demonstrate that maternal HGF diet impairs vascular constriction function in offspring through the miR-325-3p/SHIP2/NOX2 pathway. These novel findings indicate that the detrimental effects of maternal HGF …
View article: Prenatal glucocorticoids exposure and adverse cardiovascular effects in offspring
Prenatal glucocorticoids exposure and adverse cardiovascular effects in offspring Open
Glucocorticoids (GCs) are steroid hormones fundamental to the body’s normal physiological functions and are pivotal in fetal growth and development. During gestation, the mother’s cortisol concentration (active GCs) escalates to accommodat…
View article: Biohybrid hydrogel inhibiting β-klotho/HDAC3 axis for hepatocellular carcinoma treatment
Biohybrid hydrogel inhibiting β-klotho/HDAC3 axis for hepatocellular carcinoma treatment Open
Hepatocellular carcinoma (HCC), ranking as the fourth most prevalent cancer globally, has garnered significant attention due to its high invasiveness and mortality rates. However, drug therapies face challenges of inadequate efficacy and u…
View article: DNA methylation landscape in pregnancy-induced hypertension: progress and challenges
DNA methylation landscape in pregnancy-induced hypertension: progress and challenges Open
Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence suggests that epigenetic modific…
View article: <scp>DNA</scp> methylation‐mediated <scp>11βHSD2</scp> downregulation drives the increases in angiotensin‐converting enzyme and angiotensin <scp>II</scp> within preeclamptic placentas
<span>DNA</span> methylation‐mediated <span>11βHSD2</span> downregulation drives the increases in angiotensin‐converting enzyme and angiotensin <span>II</span> within preeclamptic placentas Open
Preeclampsia (PE) is a complex human‐specific complication frequently associated with placental pathology. The local renin‐angiotensin system (RAS) in the human placenta, which plays a crucial role in regulating placental function, has bee…
View article: Calcium signals and potential therapy targets in ovarian cancer (Review)
Calcium signals and potential therapy targets in ovarian cancer (Review) Open
Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention…
View article: Peripheral CD4+CD25hiCD127low regulatory T cells are increased in patients with gastrointestinal cancer
Peripheral CD4+CD25hiCD127low regulatory T cells are increased in patients with gastrointestinal cancer Open
Background Regulatory T cells (Tregs) play an important role in regulation of immune response and immunologic tolerance in cancer. Gastrointestinal cancer is still a leading cause of cancer-related death in the world. This study aimed to d…
View article: Identification of Hub Genes for Colorectal Cancer with Liver Metastasis Using miRNA-mRNA Network
Identification of Hub Genes for Colorectal Cancer with Liver Metastasis Using miRNA-mRNA Network Open
Background. Liver metastasis is an important cause of death in patients with colorectal cancer (CRC). Increasing evidence indicates that microRNAs (miRNAs) are involved in the pathogenesis of colorectal cancer liver metastasis (CRLM). This…
View article: Pain Incidence and Associated Risk Factors among Cancer Patients within 72 Hours after Surgery: A Large Retrospective Analysis
Pain Incidence and Associated Risk Factors among Cancer Patients within 72 Hours after Surgery: A Large Retrospective Analysis Open
Background: A fundamental principle of pain management is to determine the distribution and causes of pain. However, relevant data among postoperative cancer patients based on a large amount of data remain sparse. Objective: We aimed to in…
View article: Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer
Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer Open
Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in who…
View article: Synergism between the metabolic syndrome components and cancer incidence: results from a prospective nested case–control study based on the China Health and Retirement Longitudinal Study (CHARLS)
Synergism between the metabolic syndrome components and cancer incidence: results from a prospective nested case–control study based on the China Health and Retirement Longitudinal Study (CHARLS) Open
Objectives Synergism between the metabolic syndrome (MetSyn) components and cancer incidence still remains inconclusive. We aimed to investigate the unique or joint role of MetSyn components in cancer onset. Design We conducted a prospecti…
View article: Research progress of placental vascular pathophysiological changes in pregnancy-induced hypertension and gestational diabetes mellitus
Research progress of placental vascular pathophysiological changes in pregnancy-induced hypertension and gestational diabetes mellitus Open
The placenta is a vital organ for fetal development, providing the fetus with nutrients, oxygen, and other important factors. Placenta is rich in blood vessels. Abnormal placental vascular function and blood circulation may lead to insuffi…
View article: Comparing Long-Term Survival Outcomes for Muscle-Invasive Bladder Cancer Patients Who Underwent with Radical Cystectomy and Bladder-Sparing Trimodality Therapy: A Multicentre Cohort Analysis
Comparing Long-Term Survival Outcomes for Muscle-Invasive Bladder Cancer Patients Who Underwent with Radical Cystectomy and Bladder-Sparing Trimodality Therapy: A Multicentre Cohort Analysis Open
Background. Although radical cystectomy (RC) is the clinical practice guideline-recommended treatment of muscle-invasive bladder cancer (MIBC), bladder-sparing trimodality therapy (TMT) has emerged as a valid treatment option. Findings com…
View article: Antenatal dexamethasone retarded fetal long bones growth and development by down-regulating of insulin-like growth factor 1 signaling in fetal rats
Antenatal dexamethasone retarded fetal long bones growth and development by down-regulating of insulin-like growth factor 1 signaling in fetal rats Open
Objective Dexamethasone (DEX), a synthetic glucocorticoid, has been widely used as a medication for premature delivery. However, the side effects of antenatal DEX treatment on fetal bone development, as well as the underlying mechanisms st…
View article: Identifiction of Potential Regulatory Network in Colorectal with Liver Metastasis
Identifiction of Potential Regulatory Network in Colorectal with Liver Metastasis Open
Background Liver metastasis is an important cause of death in patients with colorectal cancer(CRC). Increasing evidences indicates that microRNAs (miRNAs) are involved in the pathogenesis of colorectal with liver metastasis(CRLM). This stu…
View article: MicroRNA-155-5p promotes cell proliferation and invasion in lung squamous cell carcinoma through negative regulation of fibroblast growth factor 9 expression
MicroRNA-155-5p promotes cell proliferation and invasion in lung squamous cell carcinoma through negative regulation of fibroblast growth factor 9 expression Open
Our results show that miR-155-5p, as an oncogene, negative regulates FGF9 expression to promote SCC occurrence and development in the lungs.
View article: Risk of Death in Colorectal Cancer Patients with Multi-morbidities of Metabolic Syndrome: A Retrospective Multicohort Analysis
Risk of Death in Colorectal Cancer Patients with Multi-morbidities of Metabolic Syndrome: A Retrospective Multicohort Analysis Open
Purpose The prevalence of multi-morbidities with colorectal cancer (CRC) is known to be increasing. Particularly prognosis of CRC patients co-diagnosed with metabolic syndrome (MetSyn) was largely unknown. We aimed to examine the death ris…
View article: LncRNA NUTM2A‐AS1 positively modulates TET1 and HIF‐1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR‐376a
LncRNA NUTM2A‐AS1 positively modulates TET1 and HIF‐1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR‐376a Open
Long noncoding RNA NUTM2A‐AS1 has been shown to be dysregulated in non‐small cell lung carcinoma. To date, it is unclear whether NUTM2A‐AS1 plays a role in gastric cancer progression. The purpose of this study is to elucidate the molecular…
View article: Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells
Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells Open
ADP-ribosylation factor 6 (Arf6), a member of the ADP-ribosylation factor family, is overexpressed in different types of cancer cell and promotes invasion, metastasis and drug resistance. However, the potential functions of Arf6 in gastric…
View article: Ultrasonographic evaluation of enthesitis in patients with ankylosing spondylitis
Ultrasonographic evaluation of enthesitis in patients with ankylosing spondylitis Open
The aim of this study was to assess sensitivity and responsiveness of power Doppler ultrasound (PDUS) in detecting enthesitis for ankylosing spondylitis (AS) patients compared to clinical examinations. Twenty AS patients initiating etanerc…