Junli Guo
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View article: Diabetes Advances Cardiomyocyte Senescence Through Interfering <i>Rnd3</i> Expression and Function
Diabetes Advances Cardiomyocyte Senescence Through Interfering <i>Rnd3</i> Expression and Function Open
Rnd3 is a small Rho‐GTPase that has been implicated in various cardiovascular diseases. Yet, its role in diabetes‐induced cardiomyocyte senescence remains unknown. Here we tested the role of Rnd3 in cardiomyocyte senescence and diabetic ca…
View article: Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge
Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge Open
Background Preclinical studies demonstrate a cardioprotective role of eosinophils in acute myocardial infarction. Yet clinical studies show conflicting correlations between blood eosinophil counts and acute myocardial infarction risk and m…
View article: Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling
Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling Open
BACKGROUND Rnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role in diabetes-induced cardiomyocyte senescence is unclear. This study aims to investigate the role of Rnd3 in cardiomyocyte senescence in diabe…
View article: Characterization of cardiac involvement in patients with LMNA splice-site mutation–related dilated cardiomyopathy and sudden cardiac death
Characterization of cardiac involvement in patients with LMNA splice-site mutation–related dilated cardiomyopathy and sudden cardiac death Open
Introduction: LMNA splicing mutations occur in 9.1% of cases with cardiac involvement cases, but the phenotype and severity of disease they cause have not yet been systematically studied. The aim of this study was to understand the clinica…
View article: The role of immune cells in different stages of atherosclerosis
The role of immune cells in different stages of atherosclerosis Open
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of immune cells in the intima of arteries. Experimental and clinical evidence shows that both innate and adaptive immunity orchestrate the progression of a…
View article: Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling
Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling Open
This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on the general biological functions of bone marrow-derived macrophages (BMMs). BMMs from SETD4 knockout (KO) mice exhibited signi…
View article: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence Open
Objective: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expression…
View article: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence Open
BACKGROUND: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expressio…
View article: Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling
Methyltransferase SETD4 mediates macrophages proliferation through EGFR signaling Open
Purpose: Epigenetic modifications have important impacts on the biological functions of cells. This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on the general biological function…
View article: Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis
Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis Open
Aims Blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether and how eosinophils and ECP contribute to vascular calcification and atherogenesis. Meth…
View article: Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression
Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression Open
Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), also known as lysine (K)-specific demethylase 6A (KDM6A), functions as a tumor suppressor gene or oncogene depending on the tumor type and context. However, its tumor…
View article: Prognostic value of the prognostic nutritional index for patients with acute myocardial infarction undergoing percutaneous coronary intervention with variable glucose metabolism statuses: a retrospective cohort study
Prognostic value of the prognostic nutritional index for patients with acute myocardial infarction undergoing percutaneous coronary intervention with variable glucose metabolism statuses: a retrospective cohort study Open
Background: The prognostic nutritional index (PNI) and different glucose metabolisms have been separately reported to be correlated with long-term prognosis in patients with acute myocardial infarction (AMI) undergoing percutaneous coronar…
View article: Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils Open
Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rora fl/fl Il7r Cre/+ mice or induced ILC2 depletion in Icos fl‐DTR‐fl/+ Cd4 Cre/+ mice expe…
View article: Additional file 2 of Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation
Additional file 2 of Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation Open
Additional file 2. TRPV2 mRNA expression before RFCA of AF patients and health individuals.
View article: Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation
Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation Open
Background Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and that this overexpression might be detrimental for occurrence and…
View article: Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm
Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high disability and mortality. Its susceptible risk factors include old age, being male, smoking, hypertension, and aortic atherosclerosis. With the improvement of sc…
View article: Jian-Ti-Kang-Yi decoction alleviates poly(I:C)-induced pneumonia by inhibiting inflammatory response, reducing oxidative stress, and modulating host metabolism
Jian-Ti-Kang-Yi decoction alleviates poly(I:C)-induced pneumonia by inhibiting inflammatory response, reducing oxidative stress, and modulating host metabolism Open
Jian-Ti-Kang-Yi decoction (JTKY) is widely used in the treatment of COVID-19. However, the protective mechanisms of JTKY against pneumonia remain unknown. In this study, polyinosinic-polycytidylic acid (poly(I:C)), a mimic of viral dsRNA, …
View article: Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells Open
Aims Group 2 innate lymphoid cells (ILC2s) regulate adaptive and innate immunities. In mouse heart, production of myocardial infarction (MI) increased ILC2 accumulation, suggesting a role for ILC2 in cardiac dysfunction post-MI. Methods an…
View article: Impacts of histone methyltransferase SETD4 on the biology of bone marrow-derived macrophages
Impacts of histone methyltransferase SETD4 on the biology of bone marrow-derived macrophages Open
Background Epigenetic modifications have important impacts on the biological functions of cells. This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on the general biological functi…
View article: Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation
Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation Open
Background:: Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and that this overexpression might be detrimental for occurrence a…
View article: Eosinophils protect pressure overload- and β-adrenoreceptor agonist-induced cardiac hypertrophy
Eosinophils protect pressure overload- and β-adrenoreceptor agonist-induced cardiac hypertrophy Open
Aims Blood eosinophil (EOS) counts and EOS cationic protein (ECP) levels associate positively with major cardiovascular disease (CVD) risk factors and prevalence. This study investigates the role of EOS in cardiac hypertrophy. Methods and …
View article: Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities
Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities Open
Imidazole and tetrazole derivatives are widely used as clinical drugs since they possess a variety of pharmaceutical function. Zinc and iron are essential trace elements of the human body, with less toxicity and good biocompatibility. In t…
View article: [Corrigendum] SCF increases cardiac stem cell migration through PI3K/AKT and MMP‑2/‑9 signaling
[Corrigendum] SCF increases cardiac stem cell migration through PI3K/AKT and MMP‑2/‑9 signaling Open
Following the publication of this article, the authors have realized that they mistakenly used the total AKT blot featured in Fig. 4A for the GAPDH blot in Fig. 3B on p. 116. The corrected version of Fig. 3, featured the correct data for t…